Assessment of Structural Intolerance and Durability
General Structure Information 4hhv COL4A3BP crystal structure of ceramide transfer protein pleckstrin homology domain 1.75Å AUTH J.PRASHEK,T.TRUONG,X.YAOTITL CRYSTAL STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM THETITL 2 CERAMIDE TRANSFER PROTEIN: IMPLICATIONS FOR CONFORMATIONALTITL 3 CHANGE UPON LIGAND BINDING.REF PLOS ONE V. 8 79590 2013REFN ESSN 1932-6203PMID 24260258DOI 10.1371/JOURNAL.PONE.0079590 Variant Set Distributions Mapped Variants
General Structure Information 3e77 PSAT1 human phosphoserine aminotransferase in complex with plp 2.5Å AUTH L.LEHTIO,T.KARLBERG,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,AUTH 3 A.FLORES,S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KOTENYOVA,M.MOCHE,M.E.NILSSON,P.NORDLUND,T.NYMAN,K.OLESEN,AUTH 5 C.PERSSON,J.SAGEMARK,S.G.THORSELL,L.TRESAUGUES,AUTH 6 S.VAN DEN BERG,M.WELIN,M.WIKSTROM,M.WISNIEWSKA,J.WEIGELT,AUTH 7 H.SCHUELER,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL HUMAN PHOSPHOSERINE AMINOTRANSFERASE IN COMPLEX WITH PLPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2jis CSAD human cysteine sulfinic acid decarboxylase (csad) in complex with plp. 1.6Å AUTH R.COLLINS,M.MOCHE,C.ARROWSMITH,H.BERGLUND,R.BUSAM,AUTH 2 L.G.DAHLGREN,A.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,B.M.HALLBERG,I.JOHANSSON,AUTH 4 A.KALLAS,T.KARLBERG,T.KOTENYOVA,L.LEHTIO,AUTH 5 P.NORDLUND,T.NYMAN,D.OGG,C.PERSSON,J.SAGEMARK,AUTH 6 P.STENMARK,M.SUNDSTROM,A.G.THORSELL,L.TRESAUGUES,AUTH 7 S.VAN DEN BERG,J.WEIGELT,M.WELIN,AUTH 8 L.HOLMBERG-SCHIAVONETITL THE CRYSTAL STRUCTURE OF HUMAN CYSTEINE SULFINICTITL 2 ACID DECARBOXYLASE (CSAD)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3hl2 SEPSECS the crystal structure of the human sepsecs-trnasec complex 2.81Å AUTH S.PALIOURA,R.L.SHERRER,T.A.STEITZ,D.SOLL,AUTH 2 M.SIMONOVICTITL THE HUMAN SEPSECS-TRNASEC COMPLEX REVEALS THETITL 2 MECHANISM OF SELENOCYSTEINE FORMATION.REF SCIENCE V. 325 321 2009REFN ISSN 0036-8075PMID 19608919DOI 10.1126/SCIENCE.1173755 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1wvo NANS solution structure of rsgi ruh-029, an antifreeze protein like domain in human n-acetylneuraminic acid phosphate synthase gene. -1.0Å AUTH T.HAMADA,Y.ITO,T.ABE,F.HAYASHI,P.GUNTERT,M.INOUE,AUTH 2 T.KIGAWA,T.TERADA,M.SHIROUZU,M.YOSHIDA,A.TANAKA,AUTH 3 S.SUGANO,S.YOKOYAMA,H.HIROTATITL SOLUTION STRUCTURE OF THE ANTIFREEZE-LIKE DOMAINTITL 2 OF HUMAN SIALIC ACID SYNTHASEREF PROTEIN SCI. V. 15 1010 2006REFN ISSN 0961-8368PMID 16597820DOI 10.1110/PS.051700406 Variant Set Distributions Mapped […]
General Structure Information 3hy8 PNPO crystal structure of human pyridoxine 5-phosphate oxidase r229w mutant 2.5Å AUTH F.N.MUSAYEV,M.L.DI SALVO,M.A.SAAVEDRA,R.CONTESTABILE,AUTH 2 M.S.GHATGE,A.HAYNES,V.SCHIRCH,M.K.SAFOTITL MOLECULAR BASIS OF REDUCED PYRIDOXINE 5-PHOSPHATE OXIDASETITL 2 CATALYTIC ACTIVITY IN NEONATAL EPILEPTIC ENCEPHALOPATHYTITL 3 DISORDERREF J.BIOL.CHEM. V. 284 30949 2009REFN ISSN 0021-9258PMID 19759001DOI 10.1074/JBC.M109.038372 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3l6b SRR x-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor 1.5Å AUTH M.A.SMITH,V.MACK,A.EBNETH,I.MORAES,B.FELICETTI,M.WOOD,AUTH 2 D.SCHONFELD,O.MATHER,A.CESURA,J.BARKERTITL THE STRUCTURE OF MAMMALIAN SERINE RACEMASE: EVIDENCE FORTITL 2 CONFORMATIONAL CHANGES UPON INHIBITOR BINDING.REF J.BIOL.CHEM. V. 285 12873 2010REFN ISSN 0021-9258PMID 20106978DOI 10.1074/JBC.M109.050062 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2rkb SDSL serine dehydratase like-1 from human cancer cells 2.8Å AUTH T.YAMADA,J.KOMOTO,T.KASUYA,Y.TAKATA,H.OGAWA,H.MORI,AUTH 2 F.TAKUSAGAWATITL A CATALYTIC MECHANISM THAT EXPLAINS A LOW CATALYTIC ACTIVITYTITL 2 OF SERINE DEHYDRATASE LIKE-1 FROM HUMAN CANCER CELLS:TITL 3 CRYSTAL STRUCTURE AND SITE-DIRECTED MUTAGENESIS STUDIES.REF BIOCHIM.BIOPHYS.ACTA V.1780 809 2008REFN ISSN 0006-3002PMID 18342636DOI 10.1016/J.BBAGEN.2008.01.020 Variant Set Distributions Ripley’s K […]
General Structure Information 3ihj GPT2 human alanine aminotransferase 2 in complex with plp 2.3Å AUTH M.WISNIEWSKA,M.I.SIPONEN,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,A.KOTZSCH,M.MOCHE,T.K.NIELSEN,P.NORDLUND,AUTH 5 T.NYMAN,C.PERSSON,A.K.ROOS,P.SCHUTZ,L.SVENSSON,A.G.THORSELL,AUTH 6 L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,H.SCHULERTITL HUMAN GLUTAMATE PYRUVATE TRANSAMINASE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2hzp KYNU crystal structure of homo sapiens kynureninase 2.0Å AUTH S.LIMA,R.KHRISTOFOROV,C.MOMANY,R.S.PHILLIPSTITL CRYSTAL STRUCTURE OF HOMO SAPIENS KYNURENINASE.REF BIOCHEMISTRY V. 46 2735 2007REFN ISSN 0006-2960PMID 17300176DOI 10.1021/BI0616697 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants