Assessment of Structural Intolerance and Durability
General Structure Information 3l46 ECT2 crystal structure of the second brct domain of epithelial cell transforming 2 (ect2) 1.48Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,L.CROMBET,H.WANG,X.GUAN,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE SECOND BRCT DOMAIN OF EPITHELIALTITL 2 CELL TRANSFORMING 2 (ECT2)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3ote THG1L crystal structure of human trnahis guanylyltransferase (thg1)- native i 2.56Å AUTH S.J.HYDE,B.E.ECKENROTH,B.A.SMITH,W.A.EBERLEY,N.H.HEINTZ,AUTH 2 J.E.JACKMAN,S.DOUBLIETITL TRNAHIS GUANYLYLTRANSFERASE (THG1), A UNIQUE 3-5TITL 2 NUCLEOTIDYL TRANSFERASE, SHARES UNEXPECTED STRUCTURALTITL 3 HOMOLOGY WITH CANONICAL 5-3 DNA POLYMERASES.REF PROC.NATL.ACAD.SCI.USA V. 107 20305 2010REFN ISSN 0027-8424PMID 21059936DOI 10.1073/PNAS.1010436107 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1jlj GPHN 1.6 angstrom crystal structure of the human neuroreceptor anchoring and molybdenum cofactor biosynthesis protein gephyrin 1.6Å AUTH G.SCHWARZ,N.SCHRADER,R.R.MENDEL,H.J.HECHT,AUTH 2 H.SCHINDELINTITL CRYSTAL STRUCTURES OF HUMAN GEPHYRIN AND PLANTTITL 2 CNX1 G DOMAINS: COMPARATIVE ANALYSIS ANDTITL 3 FUNCTIONAL IMPLICATIONS.REF J.MOL.BIOL. V. 312 405 2001REFN ISSN 0022-2836PMID 11554796DOI 10.1006/JMBI.2001.4952 Variant Set Distributions Ripley’s […]
General Structure Information 3zyi LRRC4 netring2 in complex with ngl2 2.6Å AUTH E.SEIRADAKE,C.H.COLES,P.V.PERESTENKO,K.HARLOS,AUTH 2 R.A.J.MCILHINNEY,A.R.ARICESCU,E.Y.JONESTITL STRUCTURAL BASIS FOR CELL SURFACE PATTERNING THROUGHTITL 2 NETRING-NGL INTERACTIONSREF EMBO J. V. 30 4479 2011REFN ISSN 0261-4189PMID 21946559DOI 10.1038/EMBOJ.2011.346 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fom PVRL3 crystal structure of human nectin-3 full ectodomain (d1-d3) 3.93Å AUTH O.J.HARRISON,J.VENDOME,J.BRASCH,X.JIN,S.HONG,P.S.KATSAMBA,AUTH 2 G.AHLSEN,R.B.TROYANOVSKY,S.M.TROYANOVSKY,B.HONIG,L.SHAPIROTITL NECTIN ECTODOMAIN STRUCTURES REVEAL A CANONICAL ADHESIVETITL 2 INTERFACE.REF NAT.STRUCT.MOL.BIOL. V. 19 906 2012REFN ISSN 1545-9993PMID 22902367DOI 10.1038/NSMB.2366 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1wrm DUSP22 crystal structure of jsp-1 1.5Å AUTH T.YOKOTA,Y.NARA,A.KASHIMA,K.MATSUBARA,S.MISAWA,AUTH 2 R.KATO,S.SUGIOTITL CRYSTAL STRUCTURE OF HUMAN DUAL SPECIFICITYTITL 2 PHOSPHATASE, JNK STIMULATORY PHOSPHATASE-1, AT 1.5TITL 3 A RESOLUTIONREF PROTEINS V. 66 272 2006REFN ISSN 0887-3585PMID 17068812DOI 10.1002/PROT.21152 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3pq1 MTPAP crystal structure of human mitochondrial poly(a) polymerase (papd1) 3.1Å AUTH Y.BAI,S.K.SRIVASTAVA,J.H.CHANG,J.L.MANLEY,L.TONGTITL STRUCTURAL BASIS FOR DIMERIZATION AND ACTIVITY OF HUMANTITL 2 PAPD1, A NONCANONICAL POLY(A) POLYMERASE.REF MOL.CELL V. 41 311 2011REFN ISSN 1097-2765PMID 21292163DOI 10.1016/J.MOLCEL.2011.01.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2yhf CLEC5A 1.9 angstrom crystal structure of clec5a 1.9Å AUTH A.A.WATSON,A.A.LEBEDEV,B.A.HALL,A.E.FENTON-MAY,AUTH 2 A.A.VAGIN,W.DEJNIRATTISAI,J.FELCE,J.MONGKOLSAPAYA,AUTH 3 A.S.PALMA,Y.LIU,T.FEIZI,G.R.SCREATON,G.N.MURSHUDOV,AUTH 4 C.A.OCALLAGHANTITL STRUCTURAL FLEXIBILITY OF THE MACROPHAGE DENGUETITL 2 VIRUS RECEPTOR CLEC5A: IMPLICATIONS FOR LIGANDTITL 3 BINDING AND SIGNALING.REF J.BIOL.CHEM. V. 286 24208 2011REFN ISSN 0021-9258PMID 21566123DOI 10.1074/JBC.M111.226142 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3mk6 PANK3 substrate and inhibitor binding to pank 1.98Å AUTH R.LEONARDI,Y.M.ZHANG,M.K.YUN,R.ZHOU,F.Y.ZENG,W.LIN,J.CUI,AUTH 2 T.CHEN,C.O.ROCK,S.W.WHITE,S.JACKOWSKITITL MODULATION OF PANTOTHENATE KINASE 3 ACTIVITY BY SMALLTITL 2 MOLECULES THAT INTERACT WITH THE SUBSTRATE/ALLOSTERICTITL 3 REGULATORY DOMAIN.REF CHEM.BIOL. V. 17 892 2010REFN ISSN 1074-5521PMID 20797618DOI 10.1016/J.CHEMBIOL.2010.06.006 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3a6p XPO5 crystal structure of exportin-5:rangtp:pre-mirna complex 2.92Å AUTH C.OKADA,E.YAMASHITA,S.J.LEE,S.SHIBATA,J.KATAHIRA,A.NAKAGAWA,AUTH 2 Y.YONEDA,T.TSUKIHARATITL A HIGH-RESOLUTION STRUCTURE OF THE PRE-MICRORNA NUCLEARTITL 2 EXPORT MACHINERYREF SCIENCE V. 326 1275 2009REFN ISSN 0036-8075PMID 19965479DOI 10.1126/SCIENCE.1178705 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants