General Structure Information 4i6h PLK2 selective & brain-permeable polo-like kinase-2 (plk-2) inhibitors that reduce alpha-synuclein phosphorylation in rat brain 1.91Å AUTH D.L.AUBELE,R.K.HOM,M.ADLER,R.A.GALEMMO,S.BOWERS,A.P.TRUONG,AUTH 2 H.PAN,P.BEROZA,R.J.NEITZ,N.YAO,M.LIN,G.TONN,H.ZHANG,AUTH 3 M.P.BOVA,Z.REN,D.TAM,L.RUSLIM,J.BAKER,L.DIEP,K.FITZGERALD,AUTH 4 J.HOFFMAN,R.MOTTER,D.FAUSS,P.TANAKA,M.DAPPEN,J.JAGODZINSKI,AUTH 5 W.CHAN,A.W.KONRADI,L.LATIMER,Y.L.ZHU,H.L.SHAM,J.P.ANDERSON,AUTH 6 M.BERGERON,D.R.ARTISTITL SELECTIVE & BRAIN-PERMEABLE POLO-LIKE KINASE-2 (PLK-2)TITL 2 INHIBITORS THAT REDUCE ALPHA-SYNUCLEIN PHOSPHORYLATION INTITL 3 RAT BRAINREF CHEMMEDCHEM V. 8 1295 2013REFN ISSN 1860-7179PMID […]
General Structure Information 3cz9 PARK7 crystal structure of e18l dj-1 1.15Å AUTH A.C.WITT,M.LAKSHMINARASIMHAN,B.C.REMINGTON,S.HASIM,AUTH 2 E.POZHARSKI,M.A.WILSONTITL CYSTEINE PKA DEPRESSION BY A PROTONATED GLUTAMICTITL 2 ACID IN HUMAN DJ-1.REF BIOCHEMISTRY V. 47 7430 2008REFN ISSN 0006-2960PMID 18570440DOI 10.1021/BI800282D Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3d6t LRRK2 structure of the roc domain from the parkinsons disease-associated leucine-rich repeat kinase 2 reveals a dimeric gtpase 2.43Å AUTH J.DENG,P.A.LEWIS,E.GREGGIO,E.SLUCH,A.BEILINA,M.R.COOKSONTITL STRUCTURE OF THE ROC DOMAIN FROM THE PARKINSONSTITL 2 DISEASE-ASSOCIATED LEUCINE-RICH REPEAT KINASE 2 REVEALS ATITL 3 DIMERIC GTPASEREF PROC.NATL.ACAD.SCI.USA V. 105 1499 2008REFN ISSN 0027-8424PMID 18230735DOI 10.1073/PNAS.0709098105 Variant Set […]
General Structure Information 3rch DDC crystal structure of human aromatic l-amino acid decarboxylase (aadc) in the open conformation with llp and plp bound to chain-a and chain- b respectively 2.8Å AUTH G.GIARDINA,R.MONTIOLI,S.GIANNI,B.CELLINI,A.PAIARDINI,AUTH 2 C.B.VOLTATTORNI,F.CUTRUZZOLATITL OPEN CONFORMATION OF HUMAN DOPA DECARBOXYLASE REVEALS THETITL 2 MECHANISM OF PLP ADDITION TO GROUP II DECARBOXYLASES.REF PROC.NATL.ACAD.SCI.USA V. 108 20514 […]