General Structure Information 3mdv CYP46A1 clotrimazole complex of cytochrome p450 46a1 2.4Å AUTH N.MAST,C.CHARVET,I.A.PIKULEVA,C.D.STOUTTITL STRUCTURAL BASIS OF DRUG BINDING TO CYP46A1, AN ENZYME THATTITL 2 CONTROLS CHOLESTEROL TURNOVER IN THE BRAIN.REF J.BIOL.CHEM. V. 285 31783 2010REFN ISSN 0021-9258PMID 20667828DOI 10.1074/JBC.M110.143313 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3t3s CYP2A13 human cytochrome p450 2a13 in complex with pilocarpine 3.0Å AUTH N.M.DEVORE,K.M.MENEELY,A.G.BART,E.S.STEPHENS,K.P.BATTAILE,AUTH 2 E.E.SCOTTTITL STRUCTURAL COMPARISON OF CYTOCHROMES P450 2A6, 2A13, AND 2E1TITL 2 WITH PILOCARPINE.REF FEBS J. V. 279 1621 2012REFN ISSN 1742-464XPMID 22051186DOI 10.1111/J.1742-4658.2011.08412.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3czh CYP2R1 crystal structure of cyp2r1 in complex with vitamin d2 2.3Å AUTH N.V.STRUSHKEVICH,W.TEMPEL,A.A.GILEP,P.LOPPNAU,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,M.WILKSTROM,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF CYP2R1 IN COMPLEX WITHTITL 2 VITAMIN D2.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ld6 CYP51A1 crystal structure of human lanosterol 14alpha-demethylase (cyp51) in complex with ketoconazole 2.8Å AUTH N.STRUSHKEVICH,S.A.USANOV,H.W.PARKTITL STRUCTURAL BASIS OF HUMAN CYP51 INHIBITION BY ANTIFUNGALTITL 2 AZOLES.REF J.MOL.BIOL. V. 397 1067 2010REFN ISSN 0022-2836PMID 20149798DOI 10.1016/J.JMB.2010.01.075 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2iag PTGIS crystal structure of human prostacyclin synthase 2.15Å AUTH C.-W.CHIANG,H.-C.YEH,L.-H.WANG,N.-L.CHANTITL CRYSTAL STRUCTURE OF THE HUMAN PROSTACYCLINTITL 2 SYNTHASEREF J.MOL.BIOL. V. 364 266 2006REFN ISSN 0022-2836PMID 17020766DOI 10.1016/J.JMB.2006.09.039 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ua5 CYP2B6 crystal structure of p450 2b6 (y226h/k262r) in complex with two molecules of amlodipine 2.8Å AUTH M.B.SHAH,P.R.WILDERMAN,J.PASCUAL,Q.ZHANG,C.D.STOUT,AUTH 2 J.R.HALPERTTITL CONFORMATIONAL ADAPTATION OF HUMAN CYTOCHROME P450 2B6 ANDTITL 2 RABBIT CYTOCHROME P450 2B4 REVEALED UPON BINDING MULTIPLETITL 3 AMLODIPINE MOLECULES.REF BIOCHEMISTRY V. 51 7225 2012REFN ISSN 0006-2960PMID 22909231DOI 10.1021/BI300894Z Variant Set Distributions […]
General Structure Information 1z10 CYP2A6 crystal structure of human microsomal p450 2a6 with coumarin bound 1.9Å AUTH J.K.YANO,M.H.HSU,K.J.GRIFFIN,C.D.STOUT,E.F.JOHNSONTITL STRUCTURES OF HUMAN MICROSOMAL CYTOCHROME P450 2A6 COMPLEXEDTITL 2 WITH COUMARIN AND METHOXSALENREF NAT.STRUCT.MOL.BIOL. V. 12 822 2005REFN ISSN 1545-9993PMID 16086027DOI 10.1038/NSMB971 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4i8v CYP1A1 human cytochrome p450 1a1 in complex with alpha-naphthoflavone 2.6Å AUTH A.A.WALSH,G.D.SZKLARZ,E.E.SCOTTTITL HUMAN CYTOCHROME P450 1A1 STRUCTURE AND UTILITY INTITL 2 UNDERSTANDING DRUG AND XENOBIOTIC METABOLISM.REF J.BIOL.CHEM. V. 288 12932 2013REFN ISSN 0021-9258PMID 23508959DOI 10.1074/JBC.M113.452953 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2hi4 CYP1A2 crystal structure of human microsomal p450 1a2 in complex with alpha-naphthoflavone 1.95Å AUTH S.SANSEN,J.K.YANO,R.L.REYNALD,G.A.SCHOCH,AUTH 2 K.J.GRIFFIN,C.D.STOUT,E.F.JOHNSONTITL ADAPTATIONS FOR THE OXIDATION OF POLYCYCLICTITL 2 AROMATIC HYDROCARBONS EXHIBITED BY THE STRUCTURETITL 3 OF HUMAN P450 1A2.REF J.BIOL.CHEM. V. 282 14348 2007REFN ISSN 0021-9258PMID 17311915DOI 10.1074/JBC.M611692200 Variant Set Distributions Ripley’s K Analysis Plots […]