Assessment of Structural Intolerance and Durability
General Structure Information 1fgu RPA1 ssdna-binding domain of the large subunit of replication protein a 2.5Å AUTH E.BOCHKAREVA,V.BELEGU,S.KOROLEV,A.BOCHKAREVTITL STRUCTURE OF THE MAJOR SINGLE-STRANDED DNA-BINDINGTITL 2 DOMAIN OF REPLICATION PROTEIN A SUGGESTS A DYNAMICTITL 3 MECHANISM FOR DNA BINDING.REF EMBO J. V. 20 612 2001REFN ISSN 0261-4189PMID 11157767DOI 10.1093/EMBOJ/20.3.612 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4luo RPA1 fragment-based discovery of a potent inhibitor of replication protein a protein-protein interactions 1.54Å AUTH A.O.FRANK,M.D.FELDKAMP,J.P.KENNEDY,A.G.WATERSON,N.F.PELZ,AUTH 2 J.D.PATRONE,B.VANGAMUDI,D.V.CAMPER,O.W.ROSSANESE,W.J.CHAZIN,AUTH 3 S.W.FESIKTITL DISCOVERY OF A POTENT INHIBITOR OF REPLICATION PROTEIN ATITL 2 PROTEIN-PROTEIN INTERACTIONS USING A FRAGMENT-LINKINGTITL 3 APPROACH.REF J.MED.CHEM. V. 56 9242 2013REFN ISSN 0022-2623PMID 24147804DOI 10.1021/JM401333U Variant Set Distributions Mapped Variants
General Structure Information 2z6k RPA2 crystal structure of full-length human rpa14/32 heterodimer 3.0Å AUTH X.DENG,J.E.HABEL,V.KABALEESWARAN,E.H.SNELL,AUTH 2 M.S.WOLD,G.E.BORGSTAHLTITL STRUCTURE OF THE FULL-LENGTH HUMAN RPA14/32TITL 2 COMPLEX GIVES INSIGHTS INTO THE MECHANISM OF DNATITL 3 BINDING AND COMPLEX FORMATIONREF J.MOL.BIOL. V. 374 865 2007REFN ISSN 0022-2836PMID 17976647DOI 10.1016/J.JMB.2007.09.074 Variant Set Distributions Mapped Variants
General Structure Information 4ilw MMP10 complex of matrix metalloproteinase-10 catalytic domain (mmp-10cd) with tissue inhibitor of metalloproteinases-2 (timp-2) 2.1Å AUTH J.BATRA,A.S.SOARES,C.MEHNER,E.S.RADISKYTITL MATRIX METALLOPROTEINASE-10/TIMP-2 STRUCTURE AND ANALYSESTITL 2 DEFINE CONSERVED CORE INTERACTIONS AND DIVERSE EXOSITETITL 3 INTERACTIONS IN MMP/TIMP COMPLEXES.REF PLOS ONE V. 8 75836 2013REFN ESSN 1932-6203PMID 24073280DOI 10.1371/JOURNAL.PONE.0075836 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3kls C5 structure of complement c5 in complex with ssl7 3.6Å AUTH N.S.LAURSEN,N.GORDON,S.HERMANS,N.LORENZ,N.JACKSON,B.WINES,AUTH 2 E.SPILLNER,J.B.CHRISTENSEN,M.JENSEN,F.FREDSLUND,M.BJERRE,AUTH 3 L.SOTTRUP-JENSEN,J.D.FRASER,G.R.ANDERSENTITL STRUCTURAL BASIS FOR INHIBITION OF COMPLEMENT C5 BY THE SSL7TITL 2 PROTEIN FROM STAPHYLOCOCCUS AUREUSREF PROC.NATL.ACAD.SCI.USA V. 107 3681 2010REFN ISSN 0027-8424PMID 20133685DOI 10.1073/PNAS.0910565107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]