Assessment of Structural Intolerance and Durability
General Structure Information 4li0 RAB8A crystal structure of gdp-bound rab8:grab 3.3Å AUTH Z.GUO,X.HOU,R.S.GOODY,A.ITZENTITL INTERMEDIATES IN THE GUANINE NUCLEOTIDE EXCHANGE REACTION OFTITL 2 RAB8 PROTEIN CATALYZED BY GUANINE NUCLEOTIDE EXCHANGETITL 3 FACTORS RABIN8 AND GRAB.REF J.BIOL.CHEM. V. 288 32466 2013REFN ISSN 0021-9258PMID 24072714DOI 10.1074/JBC.M113.498329 Variant Set Distributions Mapped Variants
General Structure Information 1xdv SOS1 experimentally phased structure of human the son of sevenless protein at 4.1 ang. 4.1Å AUTH H.SONDERMANN,S.M.SOISSON,S.BOYKEVISCH,S.S.YANG,AUTH 2 D.BAR-SAGI,J.KURIYANTITL STRUCTURAL ANALYSIS OF AUTOINHIBITION IN THE RASTITL 2 ACTIVATOR SON OF SEVENLESS.REF CELL(CAMBRIDGE,MASS.) V. 119 393 2004REFN ISSN 0092-8674PMID 15507210DOI 10.1016/J.CELL.2004.10.005 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2kmv ATP7A solution structure of the nucleotide binding domain of the human menkes protein in the atp-free form -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,S.INAGAKI,M.MIGLIARDI,AUTH 2 A.ROSATOTITL THE BINDING MODE OF ATP REVEALED BY THE SOLUTIONTITL 2 STRUCTURE OF THE N-DOMAIN OF HUMAN ATP7A.REF J.BIOL.CHEM. 2009REFN ESSN 1083-351XPMID 19917612DOI 10.1074/JBC.M109.054262 Variant Set Distributions Mapped Variants
General Structure Information 3jui EIF2B5 crystal structure of the c-terminal domain of human translation initiation factor eif2b epsilon subunit 2.0Å AUTH J.WEI,H.XU,C.ZHANG,M.WANG,F.GAO,W.GONGTITL CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMANTITL 2 TRANSLATION INITIATION FACTOR EIF2B EPSILON SUBUNITREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4li0 RAB8A crystal structure of gdp-bound rab8:grab 3.3Å AUTH Z.GUO,X.HOU,R.S.GOODY,A.ITZENTITL INTERMEDIATES IN THE GUANINE NUCLEOTIDE EXCHANGE REACTION OFTITL 2 RAB8 PROTEIN CATALYZED BY GUANINE NUCLEOTIDE EXCHANGETITL 3 FACTORS RABIN8 AND GRAB.REF J.BIOL.CHEM. V. 288 32466 2013REFN ISSN 0021-9258PMID 24072714DOI 10.1074/JBC.M113.498329 Variant Set Distributions Mapped Variants
General Structure Information 3efh PRPS1 crystal structure of human phosphoribosyl pyrophosphate synthetase 1 2.6Å AUTH X.PENG,X.LITITL CRYSTAL STRUCTURE OF HUMAN PHOSPHORIBOSYLTITL 2 PYROPHOSPHATE SYNTHETASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1foe RAC1 crystal structure of rac1 in complex with the guanine nucleotide exchange region of tiam1 2.8Å AUTH D.K.WORTHYLAKE,K.L.ROSSMAN,J.SONDEKTITL CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THETITL 2 GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1.REF NATURE V. 408 682 2000REFN ISSN 0028-0836PMID 11130063DOI 10.1038/35047014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2dm1 VAV2 solution structure of the second sh3 domain of human protein vav-2 -1.0Å AUTH H.ENDO,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND SH3 DOMAIN OFTITL 2 HUMAN PROTEIN VAV-2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1pve RAD23B solution structure of xpc binding domain of hhr23b -1.0Å AUTH B.KIM,K.S.RYU,H.J.KIM,S.J.CHO,B.S.CHOITITL SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF THETITL 2 XPC-BINDING DOMAIN OF THE HUMAN DNA REPAIR PROTEINTITL 3 HHR23B.REF FEBS J. V. 272 2467 2005REFN ISSN 1742-464XPMID 15885096DOI 10.1111/J.1742-4658.2005.04667.X Variant Set Distributions Mapped Variants
General Structure Information 3law RAB7A structure of gtp-bound l129f mutant rab7 2.8Å AUTH B.A.MCCRAY,E.SKORDALAKES,J.P.TAYLORTITL DISEASE MUTATIONS IN RAB7 RESULT IN UNREGULATED NUCLEOTIDETITL 2 EXCHANGE AND INAPPROPRIATE ACTIVATION.REF HUM.MOL.GENET. V. 19 1033 2010REFN ISSN 0964-6906PMID 20028791DOI 10.1093/HMG/DDP567 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants