Assessment of Structural Intolerance and Durability
General Structure Information 1uw4 UPF3B the structural basis of the interaction between nonsense mediated decay factors upf2 and upf3 1.95Å AUTH J.KADLEC,E.IZAURRALDE,S.CUSACKTITL THE STRUCTURAL BASIS FOR THE INTERACTION BETWEENTITL 2 NONSENSE-MEDIATED MRNA DECAY FACTORS UPF2 AND UPF3REF NAT.STRUCT.MOL.BIOL. V. 11 330 2004REFN ISSN 1545-9993PMID 15004547DOI 10.1038/NSMB741 Variant Set Distributions Mapped Variants
General Structure Information 4lt6 PAPOLG crystal structure of human poly(a) polymerase gamma 2.79Å AUTH Q.YANG,L.W.NAUSCH,G.MARTIN,W.KELLER,S.DOUBLIETITL CRYSTAL STRUCTURE OF HUMAN POLY(A) POLYMERASE GAMMA REVEALSTITL 2 A CONSERVED CATALYTIC CORE FOR CANONICAL POLY(A)TITL 3 POLYMERASES.REF J.MOL.BIOL. V. 426 43 2014REFN ISSN 0022-2836PMID 24076191DOI 10.1016/J.JMB.2013.09.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1wbp SRPK1 srpk1 bound to 9mer docking motif peptide 2.4Å AUTH J.C.NGO,S.CHAKRABARTI,J.-H.DING,A.VELAZQUEZ-DONES,AUTH 2 B.NOLEN,B.E.AUBOL,J.A.ADAMS,X.-D.FU,G.GHOSHTITL INTERPLAY BETWEEN SRPK AND CLK/STY KINASES INTITL 2 PHOSPHORYLATION OF THE SPLICING FACTOR ASF/SF2 ISTITL 3 REGULATED BY A DOCKING MOTIF IN ASF/SF2REF MOL.CELL V. 20 77 2005REFN ISSN 1097-2765PMID 16209947DOI 10.1016/J.MOLCEL.2005.08.025 Variant Set Distributions Mapped Variants
General Structure Information 3bl7 DCPS synthetic gene encoded dcps bound to inhibitor dg156844 2.31Å AUTH J.SINGH,M.SALCIUS,S.W.LIU,B.L.STAKER,R.MISHRA,AUTH 2 J.THURMOND,G.MICHAUD,D.R.MATTOON,J.PRINTEN,AUTH 3 J.CHRISTENSEN,J.M.BJORNSSON,B.A.POLLOK,M.KILEDJIAN,AUTH 4 L.STEWART,J.JARECKI,M.E.GURNEYTITL DCPS AS A THERAPEUTIC TARGET FOR SPINAL MUSCULARTITL 2 ATROPHY.REF ACS CHEM.BIOL. V. 3 711 2008REFN ISSN 1554-8929PMID 18839960DOI 10.1021/CB800120T Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3i4r NUP133 nup107(aa658-925)/nup133(aa517-1156) complex, h.sapiens 3.53Å AUTH J.R.WHITTLE,T.U.SCHWARTZTITL ARCHITECTURAL NUCLEOPORINS NUP157/170 AND NUP133TITL 2 ARE STRUCTURALLY RELATED AND DESCEND FROM A SECONDTITL 3 ANCESTRAL ELEMENT.REF J.BIOL.CHEM. V. 284 28442 2009REFN ISSN 0021-9258PMID 19674973DOI 10.1074/JBC.M109.023580 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wjv UPF1 crystal structure of the complex between human nonsense mediated decay factors upf1 and upf2 2.85Å AUTH M.CLERICI,A.MOURAO,I.GUTSCHE,N.H.GEHRING,M.W.HENTZE,AUTH 2 A.KULOZIK,J.KADLEC,M.SATTLER,S.CUSACKTITL UNUSUAL BIPARTITE MODE OF INTERACTION BETWEEN THETITL 2 NONSENSE-MEDIATED DECAY FACTORS, UPF1 AND UPF2.REF EMBO J. V. 28 2293 2009REFN ISSN 0261-4189PMID 19556969DOI 10.1038/EMBOJ.2009.175 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3cou NUDT16 crystal structure of human nudix motif 16 (nudt16) 1.8Å AUTH L.TRESAUGUES,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,AUTH 4 M.D.HERMAN,A.JOHANSSON,I.JOHANSSON,A.KALLAS,AUTH 5 T.KARLBERG,T.KOTENYOVA,L.LEHTIO,M.E.NILSSON,AUTH 6 T.NYMAN,C.PERSSON,J.SAGEMARK,H.SCHUELER,L.SVENSSON,AUTH 7 A.G.THORSELL,S.VAN DEN BERG,M.WELIN,J.WEIGELT,AUTH 8 M.WIKSTROM,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN NUDIX MOTIF 16 (NUDT16).REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2jvz KHSRP solution nmr structure of the second and third kh domains of ksrp -1.0Å AUTH I.DIAZ-MORENO,D.HOLLINGWORTH,M.F.GARCIA-MAYORAL,AUTH 2 G.KELLY,S.MARTIN,C.Y.CHEN,A.RAMOSTITL SOLUTION NMR STRUCTURE OF THE SECOND AND THIRD KHTITL 2 DOMAINS OF KSRPREF TO BE PUBLISHED 2007REFN Variant Set Distributions Mapped Variants
General Structure Information 3sde PSPC1 crystal structure of a paraspeckle-protein heterodimer, pspc1/nono 1.9Å AUTH D.M.PASSON,M.LEE,O.RACKHAM,W.A.STANLEY,A.SADOWSKA,AUTH 2 A.FILIPOVSKA,A.H.FOX,C.S.BONDTITL STRUCTURE OF THE HETERODIMER OF HUMAN NONO AND PARASPECKLETITL 2 PROTEIN COMPONENT 1 AND ANALYSIS OF ITS ROLE IN SUBNUCLEARTITL 3 BODY FORMATION.REF PROC.NATL.ACAD.SCI.USA V. 109 4846 2012REFN ISSN 0027-8424PMID 22416126DOI 10.1073/PNAS.1120792109 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4n48 CMTR1 cap-specific mrna (nucleoside-2-o-)-methyltransferase 1 protein in complex with capped rna fragment 2.7Å AUTH M.SMIETANSKI,M.WERNER,E.PURTA,K.H.KAMINSKA,J.STEPINSKI,AUTH 2 E.DARZYNKIEWICZ,M.NOWOTNY,J.M.BUJNICKITITL STRUCTURAL ANALYSIS OF HUMAN 2-O-RIBOSE METHYLTRANSFERASESTITL 2 INVOLVED IN MRNA CAP STRUCTURE FORMATION.REF NAT COMMUN V. 5 3004 2014REFN ESSN 2041-1723PMID 24402442DOI 10.1038/NCOMMS4004 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]