Assessment of Structural Intolerance and Durability
General Structure Information 3ex7 RBM8A the crystal structure of ejc in its transition state 2.3Å AUTH K.H.NIELSEN,H.CHAMIEH,C.B.ANDERSEN,F.FREDSLUND,AUTH 2 K.HAMBORG,H.LE HIR,G.R.ANDERSENTITL MECHANISM OF ATP TURNOVER INHIBITION IN THE EJCREF RNA V. 15 67 2009REFN ISSN 1355-8382PMID 19033377DOI 10.1261/RNA.1283109 Variant Set Distributions Mapped Variants
General Structure Information 2rb4 DDX25 crystal structure of the helicase domain of human ddx25 rna helicase 2.8Å AUTH P.SCHUTZ,T.KARLBERG,S.VAN DEN BERG,R.COLLINS,L.LEHTIO,AUTH 2 M.HOGBOM,L.HOLMBERG-SCHIAVONE,W.TEMPEL,H.W.PARK,AUTH 3 M.HAMMARSTROM,M.MOCHE,A.G.THORSELL,H.SCHULERTITL COMPARATIVE STRUCTURAL ANALYSIS OF HUMAN DEAD-BOX RNATITL 2 HELICASES.REF PLOS ONE V. 5 12791 2010REFN ESSN 1932-6203PMID 20941364DOI 10.1371/JOURNAL.PONE.0012791 Variant Set Distributions Mapped Variants
General Structure Information 2r99 PPIE crystal structure of cyclophilin abh-like domain of human peptidylprolyl isomerase e isoform 1 1.61Å AUTH J.R.WALKER,T.DAVIS,E.M.NEWMAN,F.MACKENZIE,AUTH 2 M.SUNDSTROM,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL X-RAY CRYSTAL STRUCTURE OF THE CYCLOPHILIN DOMAINTITL 2 OF HUMAN PEPTIDYLPROLYL ISOMERASE E ISOFORM 1.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4gmj CNOT7 structure of human not1 mif4g domain co-crystallized with caf1 2.7Å AUTH A.P.PETIT,L.WOHLBOLD,P.BAWANKAR,E.HUNTZINGER,S.SCHMIDT,AUTH 2 E.IZAURRALDE,O.WEICHENRIEDERTITL THE STRUCTURAL BASIS FOR THE INTERACTION BETWEEN THE CAF1TITL 2 NUCLEASE AND THE NOT1 SCAFFOLD OF THE HUMAN CCR4-NOTTITL 3 DEADENYLASE COMPLEXREF NUCLEIC ACIDS RES. V. 40 11058 2012REFN ISSN 0305-1048PMID 22977175DOI 10.1093/NAR/GKS883 Variant Set Distributions […]
General Structure Information 3ews DDX19B human dead-box rna-helicase ddx19 in complex with adp 2.7Å AUTH R.COLLINS,T.KARLBERG,L.LEHTIO,P.SCHUTZ,AUTH 2 S.VAN DEN BERG,L.G.DAHLGREN,M.HAMMARSTROM,AUTH 3 J.WEIGELT,H.SCHULERTITL THE DEXD/H-BOX RNA HELICASE DDX19 IS REGULATED BYTITL 2 AN {ALPHA}-HELICAL SWITCH.REF J.BIOL.CHEM. V. 284 10296 2009REFN ISSN 0021-9258PMID 19244245DOI 10.1074/JBC.C900018200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4c0d CNOT2 structure of the not module of the human ccr4-not complex (cnot1-cnot2-cnot3) 3.2Å AUTH A.BOLAND,Y.CHEN,T.RAISCH,S.JONAS,D.KUZUOGLU-OZTURK,AUTH 2 L.WOHLBOLD,O.WEICHENRIEDER,E.IZAURRALDETITL STRUCTURE AND ASSEMBLY OF THE NOT MODULE OF THE HUMANTITL 2 CCR4-NOT COMPLEXREF NAT.STRUCT.MOL.BIOL. V. 20 1289 2013REFN ISSN 1545-9993PMID 24121232DOI 10.1038/NSMB.2681 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4dhx ENY2 eny2:ganp complex 2.1Å AUTH D.JANI,S.LUTZ,E.HURT,R.A.LASKEY,M.STEWART,V.O.WICKRAMASINGHETITL FUNCTIONAL AND STRUCTURAL CHARACTERIZATION OF THE MAMMALIANTITL 2 TREX-2 COMPLEX THAT LINKS TRANSCRIPTION WITH NUCLEARTITL 3 MESSENGER RNA EXPORT.REF NUCLEIC ACIDS RES. V. 40 4562 2012REFN ISSN 0305-1048PMID 22307388DOI 10.1093/NAR/GKS059 Variant Set Distributions Mapped Variants
General Structure Information 1uw4 UPF2 the structural basis of the interaction between nonsense mediated decay factors upf2 and upf3 1.95Å AUTH J.KADLEC,E.IZAURRALDE,S.CUSACKTITL THE STRUCTURAL BASIS FOR THE INTERACTION BETWEENTITL 2 NONSENSE-MEDIATED MRNA DECAY FACTORS UPF2 AND UPF3REF NAT.STRUCT.MOL.BIOL. V. 11 330 2004REFN ISSN 1545-9993PMID 15004547DOI 10.1038/NSMB741 Variant Set Distributions Mapped Variants
General Structure Information 3gix TXNL4B crystal structure of human splicing factor dim2 1.33Å AUTH T.C.JIN,F.GUO,Y.T.WANG,A.HOWARD,Y.Z.ZHANGTITL CRYSTAL STRUCTURE OF HUMAN SPLICING FACTOR DIM2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4h87 SLC4A1AP crystal structure of a fha domain of kanadaptin (slc4a1ap) from homo sapiens at 1.55 a resolution 1.55Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG)TITL CRYSTAL STRUCTURE OF A FHA DOMAIN OF KANADAPTIN (SLC4A1AP)TITL 2 FROM HOMO SAPIENS AT 1.55 A RESOLUTIONREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants