Assessment of Structural Intolerance and Durability
General Structure Information 2l0f POLI solution nmr structure of human polymerase iota ubm2 (p692a mutant) in complex with ubiquitin -1.0Å AUTH G.CUI,R.C.BENIRSCHKE,H.F.TUAN,N.JURANIC,S.MACURA,AUTH 2 M.V.BOTUYAN,G.MERTITL STRUCTURAL BASIS OF UBIQUITIN RECOGNITION BY TRANSLESIONTITL 2 SYNTHESIS DNA POLYMERASE IOTA.REF BIOCHEMISTRY V. 49 10198 2010REFN ISSN 0006-2960PMID 21049971DOI 10.1021/BI101303T Variant Set Distributions Mapped Variants
General Structure Information 4jqf OBFC1 structure of the c-terminal domain of human telomeric stn1 1.6Å AUTH C.BRYAN,C.RICE,M.HARKISHEIMER,D.C.SCHULTZ,E.SKORDALAKESTITL STRUCTURE OF THE HUMAN TELOMERIC STN1-TEN1 CAPPING COMPLEX.REF PLOS ONE V. 8 66756 2013REFN ESSN 1932-6203PMID 23826127DOI 10.1371/JOURNAL.PONE.0066756 Variant Set Distributions Mapped Variants
General Structure Information 2ac3 MKNK2 structure of human mnk2 kinase domain 2.1Å AUTH R.JAUCH,S.JAKEL,C.NETTER,K.SCHREITER,B.AICHER,H.JACKLE,AUTH 2 M.C.WAHLTITL CRYSTAL STRUCTURES OF THE MNK2 KINASE DOMAIN REVEAL ANTITL 2 INHIBITORY CONFORMATION AND A ZINC BINDING SITE.REF STRUCTURE V. 13 1559 2005REFN ISSN 0969-2126PMID 16216586DOI 10.1016/J.STR.2005.07.013 Variant Set Distributions Mapped Variants
General Structure Information 4msp FKBP14 crystal structure of human peptidyl-prolyl cis-trans isomerase fkbp22 (aka fkbp14) containing two ef-hand motifs 1.9Å AUTH S.P.BOUDKO,Y.ISHIKAWA,J.NIX,M.S.CHAPMAN,H.P.BACHINGERTITL STRUCTURE OF HUMAN PEPTIDYL-PROLYL CIS-TRANS ISOMERASETITL 2 FKBP22 CONTAINING TWO EF-HAND MOTIFS.REF PROTEIN SCI. V. 23 67 2014REFN ISSN 0961-8368PMID 24272907DOI 10.1002/PRO.2391 Variant Set Distributions Mapped Variants
General Structure Information 2dmq LHX9 solution structure of the homeobox domain of lim/homeobox protein lhx9 -1.0Å AUTH S.OHNISHI,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE HOMEOBOX DOMAIN OFTITL 2 LIM/HOMEOBOX PROTEIN LHX9REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ek1 RBM12 crystal structure of rna-binding motif of human rna-binding protein 12 2.0Å AUTH IHSANAWATI,Y.BESSHO,M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF RNA-BINDING MOTIF OF HUMANTITL 2 RNA-BINDING PROTEIN 12REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3iwp CUTC crystal structure of human copper homeostasis protein cutc 2.5Å AUTH Y.LI,J.DU,P.ZHANG,J.DINGTITL CRYSTAL STRUCTURE OF HUMAN COPPER HOMEOSTASISTITL 2 PROTEIN CUTC REVEALS A POTENTIAL COPPER-BINDINGTITL 3 SITEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2cpd A1CF solution structure of the rna recognition motif of human apobec-1 complementation factor, acf -1.0Å AUTH T.NAGATA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RNA RECOGNITION MOTIF OFTITL 2 HUMAN APOBEC-1 COMPLEMENTATION FACTOR, ACFREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2kxq SMURF2 solution structure of smurf2 ww2 and ww3 bound to smad7 py motif containing peptide -1.0Å AUTH P.A.CHONG,H.LIN,J.L.WRANA,J.D.FORMAN-KAYTITL COUPLING OF TANDEM SMAD UBIQUITINATION REGULATORY FACTORTITL 2 (SMURF) WW DOMAINS MODULATES TARGET SPECIFICITY.REF PROC.NATL.ACAD.SCI.USA V. 107 18404 2010REFN ISSN 0027-8424PMID 20937913DOI 10.1073/PNAS.1003023107 Variant Set Distributions Mapped Variants
General Structure Information 2y9t TP63 structural basis of p63a sam domain mutants involved in aec syndrome -1.0Å AUTH A.SATHYAMURTHY,S.M.V.FREUND,C.M.JOHNSON,M.D.ALLEN,M.BYCROFTTITL STRUCTURAL BASIS OF P63ALPHA SAM DOMAIN MUTANTS INVOLVED INTITL 2 AEC SYNDROME.REF FEBS J. V. 278 2680 2011REFN ISSN 1742-464XPMID 21615690DOI 10.1111/J.1742-4658.2011.08194.X Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants