Assessment of Structural Intolerance and Durability
General Structure Information 3f9y SETD8 structural insights into lysine multiple methylation by set domain methyltransferases, set8-y334f / h4-lys20me1 / adohcy 1.5Å AUTH J.F.COUTURE,L.M.DIRK,J.S.BRUNZELLE,R.L.HOUTZ,R.C.TRIEVELTITL STRUCTURAL ORIGINS FOR THE PRODUCT SPECIFICITY OF SET DOMAINTITL 2 PROTEIN METHYLTRANSFERASES.REF PROC.NATL.ACAD.SCI.USA V. 105 20659 2008REFN ISSN 0027-8424PMID 19088188DOI 10.1073/PNAS.0806712105 Variant Set Distributions Mapped Variants
General Structure Information 2rfi EHMT1 crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with sah and dimethylated h3k9 peptide 1.59Å AUTH H.WU,J.MIN,V.V.LUNIN,T.ANTOSHENKO,L.DOMBROVSKI,AUTH 2 H.ZENG,A.ALLALI-HASSANI,V.CAMPAGNA-SLATER,M.VEDADI,AUTH 3 C.H.ARROWSMITH,A.N.PLOTNIKOV,M.SCHAPIRATITL STRUCTURAL BIOLOGY OF HUMAN H3K9 METHYLTRANSFERASESREF PLOS ONE V. 5 E8570 2010REFN ESSN 1932-6203PMID 20084102DOI 10.1371/JOURNAL.PONE.0008570 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4gqb WDR77 crystal structure of the human prmt5:mep50 complex 2.06Å AUTH S.ANTONYSAMY,Z.BONDAY,R.M.CAMPBELL,B.DOYLE,Z.DRUZINA,AUTH 2 T.GHEYI,B.HAN,L.N.JUNGHEIM,Y.QIAN,C.RAUCH,M.RUSSELL,AUTH 3 J.M.SAUDER,S.R.WASSERMAN,K.WEICHERT,F.S.WILLARD,A.ZHANG,AUTH 4 S.EMTAGETITL CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 109 17960 2012REFN ISSN 0027-8424PMID 23071334DOI 10.1073/PNAS.1209814109 Variant Set Distributions Mapped Variants
General Structure Information 2wmn DOCK9 structure of the complex between dock9 and cdc42-gdp. 2.39Å AUTH J.YANG,Z.ZHANG,S.M.ROE,C.J.MARSHALL,D.BARFORDTITL ACTIVATION OF RHO GTPASES BY DOCK EXCHANGE FACTORSTITL 2 IS MEDIATED BY A NUCLEOTIDE SENSOR.REF SCIENCE V. 325 1398 2009REFN ISSN 0036-8075PMID 19745154DOI 10.1126/SCIENCE.1174468 Variant Set Distributions Mapped Variants
General Structure Information 2kje CREBBP nmr structure of cbp taz2 and adenoviral e1a complex -1.0Å AUTH J.C.FERREON,M.A.MARTINEZ-YAMOUT,H.J.DYSON,AUTH 2 P.E.WRIGHTTITL STRUCTURAL BASIS FOR SUBVERSION OF CELLULAR CONTROLTITL 2 MECHANISMS BY THE ADENOVIRAL E1A ONCOPROTEIN.REF PROC.NATL.ACAD.SCI.USA V. 106 13260 2009REFN ISSN 0027-8424PMID 19651603DOI 10.1073/PNAS.0906770106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2rnx KAT2B the structural basis for site-specific lysine-acetylated histone recognition by the bromodomains of the human transcriptional co-activators pcaf and cbp -1.0Å AUTH L.ZENG,Q.ZHANG,G.GERONA-NAVARRO,N.MOSHKINA,M.M.ZHOUTITL STRUCTURAL BASIS OF SITE-SPECIFIC HISTONETITL 2 RECOGNITION BY THE BROMODOMAINS OF HUMANTITL 3 COACTIVATORS PCAF AND CBP/P300REF STRUCTURE V. 16 643 2008REFN ISSN 0969-2126PMID 18400184DOI 10.1016/J.STR.2008.01.010 Variant Set […]
General Structure Information 2rex RND1 crystal structure of the effector domain of plxnb1 bound with rnd1 gtpase 2.3Å AUTH Y.TONG,W.TEMPEL,L.SHEN,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE EFFECTOR DOMAIN OF PLXNB1 BOUNDTITL 2 WITH RND1 GTPASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fmw TRMT10A crystal structure of methyltransferase domain of human rna (guanine-9- ) methyltransferase domain containing protein 2 2.0Å AUTH H.ZENG,A.DONG,P.LOPPNAU,W.TEMPEL,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,H.WUTITL CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMAN RNATITL 2 (GUANINE-9-) METHYLTRANSFERASE DOMAIN CONTAINING PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4n48 CMTR1 cap-specific mrna (nucleoside-2-o-)-methyltransferase 1 protein in complex with capped rna fragment 2.7Å AUTH M.SMIETANSKI,M.WERNER,E.PURTA,K.H.KAMINSKA,J.STEPINSKI,AUTH 2 E.DARZYNKIEWICZ,M.NOWOTNY,J.M.BUJNICKITITL STRUCTURAL ANALYSIS OF HUMAN 2-O-RIBOSE METHYLTRANSFERASESTITL 2 INVOLVED IN MRNA CAP STRUCTURE FORMATION.REF NAT COMMUN V. 5 3004 2014REFN ESSN 2041-1723PMID 24402442DOI 10.1038/NCOMMS4004 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2l2l GATAD2A solution structure of the coiled-coil complex between mbd2 and p66alpha -1.0Å AUTH M.N.GNANAPRAGASAM,J.N.SCARSDALE,M.L.AMAYA,H.D.WEBB,AUTH 2 M.A.DESAI,N.M.WALAVALKAR,S.Z.WANG,S.ZU ZHU,G.D.GINDER,AUTH 3 D.C.WILLIAMSTITL P66ALPHA-MBD2 COILED-COIL INTERACTION AND RECRUITMENT OFTITL 2 MI-2 ARE CRITICAL FOR GLOBIN GENE SILENCING BY THE MBD2-NURDTITL 3 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 108 7487 2011REFN ISSN 0027-8424PMID 21490301DOI 10.1073/PNAS.1015341108 Variant Set Distributions Mapped […]