Assessment of Structural Intolerance and Durability
General Structure Information 3isq HPD crystal structure of human 4-hydroxyphenylpyruvate dioxygenase 1.75Å AUTH E.S.PILKA,N.SHAFQAT,R.COCKING,J.E.BRAY,T.KROJER,A.C.W.PIKE,AUTH 2 F.VON DELFT,W.W.YUE,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,AUTH 3 C.BOUNTRA,U.OPPERMANN,K.L.KAVANAGHTITL CRYSTAL STRUCTURE OF HUMAN 4-HYDROXYPHENYLPYRUVATETITL 2 DIOXYGENASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2rop ATP7B solution structure of domains 3 and 4 of human atp7b -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,A.C.ROSENZWEIG,AUTH 2 L.A.YATSUNYKTITL METAL BINDING DOMAINS 3 AND 4 OF THE WILSONTITL 2 DISEASE PROTEIN: SOLUTION STRUCTURE ANDTITL 3 INTERACTION WITH THE COPPER(I) CHAPERONE HAH1REF BIOCHEMISTRY V. 47 7423 2008REFN ISSN 0006-2960PMID 18558714DOI 10.1021/BI8004736 Variant Set Distributions Mapped […]
General Structure Information 3fxm PPM1A crystal structure of human protein phosphatase 1a (ppm1a) bound with citrate at 10 mm of mn2+ 2.5Å AUTH T.HU,L.WANG,K.WANG,J.CHEN,H.JIANG,X.SHENTITL STRUCTURAL BASIS FOR THE MN2+-DEPENDENT ACTIVATIONTITL 2 OF HUMAN PPM1AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ihp USP5 covalent ubiquitin-usp5 complex 2.8Å AUTH J.R.WALKER,G.V.AVVAKUMOV,S.XUE,C.BUTLER-COLE,AUTH 2 J.WEIGELT,C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANONTITL COVALENT UBIQUITIN-USP5 COMPLEXREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2koy ATP7B structure of the e1064a mutant of the n-domain of wilson disease associated protein -1.0Å AUTH O.Y.DMITRIEV,S.L.LUTSENKO,E.E.UHLEMANNTITL THE STRUCTURE OF THE E1064A MUTANT REVEALS ATP-DEPENDENTTITL 2 CONFORMATIONAL CHANGES IN THE ATP7B N-DOMAIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3cki TIMP3 crystal structure of the tace-n-timp-3 complex 2.3Å AUTH M.WISNIEWSKA,P.GOETTIG,K.MASKOS,E.BELOUSKI,AUTH 2 D.WINTERS,R.HECHT,R.BLACK,W.BODETITL STRUCTURAL DETERMINANTS OF THE ADAM INHIBITION BYTITL 2 TIMP-3: CRYSTAL STRUCTURE OF THE TACE-N-TIMP-3TITL 3 COMPLEX.REF J.MOL.BIOL. V. 381 1307 2008REFN ISSN 0022-2836PMID 18638486DOI 10.1016/J.JMB.2008.06.088 Variant Set Distributions Mapped Variants
General Structure Information 2w2j CA8 crystal structure of the human carbonic anhydrase related protein viii 1.6Å AUTH S.S.PICAUD,J.R.C.MUNIZ,A.KRAMM,E.S.PILKA,G.KOCHAN,AUTH 2 U.OPPERMANN,W.W.YUETITL CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE-TITL 2 RELATED PROTEIN VIII REVEALS THE BASIS FORTITL 3 CATALYTIC SILENCING.REF PROTEINS V. 76 507 2009REFN ISSN 0887-3585PMID 19360879DOI 10.1002/PROT.22411 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3dzy PPARG intact ppar gamma – rxr alpha nuclear receptor complex on dna bound with rosiglitazone, 9-cis retinoic acid and ncoa2 peptide 3.1Å AUTH V.CHANDRA,P.HUANG,Y.HAMURO,S.RAGHURAM,Y.WANG,T.P.BURRIS,AUTH 2 F.RASTINEJADTITL STRUCTURE OF THE INTACT PPAR-GAMMA-RXR- NUCLEAR RECEPTORTITL 2 COMPLEX ON DNA.REF NATURE V. 456 350 2008REFN ISSN 0028-0836PMID 19043829DOI 10.1038/NATURE07413 Variant Set Distributions Ripley’s K […]
General Structure Information 2rgz HMOX2 ensemble refinement of the protein crystal structure of human heme oxygenase-2 c127a (ho-2) with bound heme 2.61Å AUTH C.M.BIANCHETTI,L.YI,S.W.RAGSDALE,G.N.PHILLIPS JR.TITL COMPARISON OF APO- AND HEME-BOUND CRYSTAL STRUCTURES OF ATITL 2 TRUNCATED HUMAN HEME OXYGENASE-2.REF J.BIOL.CHEM. V. 282 37624 2007REFN ISSN 0021-9258PMID 17965015DOI 10.1074/JBC.M707396200 Variant Set Distributions Mapped Variants
General Structure Information 3bim BCL6 crystal structure of the bcl6 btb domain dimer in complex with the bcor bbd corepressor peptide 2.6Å AUTH A.F.GHETU,C.M.CORCORAN,L.CERCHIETTI,V.J.BARDWELL,AUTH 2 A.MELNICK,G.G.PRIVETITL STRUCTURE OF A BCOR COREPRESSOR PEPTIDE IN COMPLEXTITL 2 WITH THE BCL6 BTB DOMAIN DIMER.REF MOL.CELL V. 29 384 2008REFN ISSN 1097-2765PMID 18280243DOI 10.1016/J.MOLCEL.2007.12.026 Variant Set Distributions Mapped Variants