Assessment of Structural Intolerance and Durability
General Structure Information 3i2b PTS the crystal structure of human 6 pyruvoyl tetrahydrobiopterin synthase 2.3Å AUTH E.UGOCHUKWU,R.COCKING,E.PILKA,W.W.YUE,J.E.BRAY,A.CHAIKUAD,AUTH 2 T.KROJER,J.MUNIZ,U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN 6 PYRUVOYLTITL 2 TETRAHYDROBIOPTERIN SYNTHASEREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2j2s KMT2A solution structure of the nonmethyl-cpg-binding cxxc domain of the leukaemia-associated mll histone methyltransferase -1.0Å AUTH M.D.ALLEN,C.G.GRUMMITT,C.HILCENKO,S.Y.MIN,AUTH 2 L.M.TONKIN,C.M.JOHNSON,S.M.FREUND,M.BYCROFT,AUTH 3 A.J.WARRENTITL SOLUTION STRUCTURE OF THE NONMETHYL-CPG-BINDINGTITL 2 CXXC DOMAIN OF THE LEUKAEMIA-ASSOCIATED MLLTITL 3 HISTONE METHYLTRANSFERASEREF EMBO J. V. 25 4503 2006REFN ISSN 0261-4189PMID 16990798DOI 10.1038/SJ.EMBOJ.7601340 Variant Set Distributions Mapped Variants
General Structure Information 3uvj GUCY1A3 crystal structure of the catalytic domain of the heterodimeric human soluble guanylate cyclase 1. 2.08Å AUTH C.K.ALLERSTON,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF HUMAN SOLUBLETITL 2 GUANYLATE CYCLASE.REF PLOS ONE V. 8 57644 2013REFN ESSN 1932-6203PMID 23505436DOI 10.1371/JOURNAL.PONE.0057644 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2c6b MDM2 solution structure of the c4 zinc-finger domain of hdm2 -1.0Å AUTH G.W.YU,M.D.ALLEN,A.ANDREEVA,A.R.FERSHT,M.BYCROFTTITL SOLUTION STRUCTURE OF THE C4 ZINC FINGER DOMAIN OFTITL 2 HDM2.REF PROTEIN SCI. V. 15 384 2006REFN ISSN 0961-8368PMID 16385008DOI 10.1110/PS.051927306 Variant Set Distributions Mapped Variants
General Structure Information 2kna XIAP solution structure of uba domain of xiap -1.0Å AUTH S.K.HUI,M.K.TSE,Y.YANG,B.C.WONG,K.H.SZETITL BACKBONE AND SIDE-CHAIN 1H, 13C AND 15N ASSIGNMENTS OF THETITL 2 UBIQUITIN-ASSOCIATED DOMAIN OF HUMAN X-LINKED INHIBITOR OFTITL 3 APOPTOSIS PROTEINREF BIOMOL.NMR ASSIGN. V. 4 13 2010REFN ISSN 1874-2718PMID 19916060DOI 10.1007/S12104-009-9197-X Variant Set Distributions Mapped Variants
General Structure Information 2wz1 GUCY1B3 structure of the catalytic domain of human soluble guanylate cyclase 1 beta 3. 1.63Å AUTH C.K.ALLERSTON,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF HUMAN SOLUBLETITL 2 GUANYLATE CYCLASE.REF PLOS ONE V. 8 57644 2013REFN ISSN 1932-6203PMID 23505436DOI 10.1371/JOURNAL.PONE.0057644 Variant Set Distributions Mapped Variants
General Structure Information 2jed PRKCQ the crystal structure of the kinase domain of the protein kinase c theta in complex with nvp-xaa228 at 2.32a resolution. 2.32Å AUTH W.STARK,F.BITSCH,A.BERNER,F.BUELENS,P.GRAFF,AUTH 2 H.DEPERSIN,G.FENDRICH,M.GEISER,R.KNECHT,J.RAHUEL,AUTH 3 G.RUMMEL,J.M.SCHLAEPPI,R.SCHMITZ,A.STRAUSS,J.WAGNERTITL THE CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF THETITL 2 PROTEIN KINASE C THETA IN COMPLEX WITH NVP-XAA228REF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 2qpw PRDM2 methyltransferase domain of human pr domain-containing protein 2 1.79Å AUTH H.WU,J.MIN,V.V.LUNIN,T.ANTOSHENKO,L.DOMBROVSKI,AUTH 2 H.ZENG,A.ALLALI-HASSANI,V.CAMPAGNA-SLATER,M.VEDADI,AUTH 3 C.H.ARROWSMITH,A.N.PLOTNIKOV,M.SCHAPIRATITL STRUCTURAL BIOLOGY OF HUMAN H3K9 METHYLTRANSFERASESREF PLOS ONE V. 5 E8570 2010REFN ESSN 1932-6203PMID 20084102DOI 10.1371/JOURNAL.PONE.0008570 Variant Set Distributions Mapped Variants
General Structure Information 2w5z KMT2A ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. 2.2Å AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 […]
General Structure Information 3bxm FOLH1 structure of an inactive mutant of human glutamate carboxypeptidase ii [gcpii(e424a)] in complex with n-acetyl-asp-glu (naag) 1.71Å AUTH V.KLUSAK,C.BARINKA,A.PLECHANOVOVA,P.MLCOCHOVA,J.KONVALINKA,AUTH 2 L.RULISEK,J.LUBKOWSKITITL REACTION MECHANISM OF GLUTAMATE CARBOXYPEPTIDASE II REVEALEDTITL 2 BY MUTAGENESIS, X-RAY CRYSTALLOGRAPHY, AND COMPUTATIONALTITL 3 METHODS.REF BIOCHEMISTRY V. 48 4126 2009REFN ISSN 0006-2960PMID 19301871DOI 10.1021/BI900220S Variant Set Distributions Ripley’s […]