Assessment of Structural Intolerance and Durability
General Structure Information 3tyy LMNB1 crystal structure of human lamin-b1 coil 2 segment 2.4Å AUTH J.RUAN,C.XU,C.BIAN,R.LAM,J.P.WANG,J.KANIA,J.MIN,J.ZANGTITL CRYSTAL STRUCTURES OF THE COIL 2B FRAGMENT AND THE GLOBULARTITL 2 TAIL DOMAIN OF HUMAN LAMIN B1.REF FEBS LETT. V. 586 314 2012REFN ISSN 0014-5793PMID 22265972DOI 10.1016/J.FEBSLET.2012.01.007 Variant Set Distributions Mapped Variants
General Structure Information 3jxf PTPRZ1 ca-like domain of human ptprz 2.0Å AUTH S.BOUYAIN,D.J.WATKINSTITL THE PROTEIN TYROSINE PHOSPHATASES PTPRZ AND PTPRGTITL 2 BIND TO DISTINCT MEMBERS OF THE CONTACTIN FAMILY OFTITL 3 NEURAL RECOGNITION MOLECULES.REF PROC.NATL.ACAD.SCI.USA V. 107 2443 2010REFN ISSN 0027-8424PMID 20133774DOI 10.1073/PNAS.0911235107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3dzf CD38 crystal structure of human cd38 extracellular domain complexed with a covalent intermediate, ara-f-ribose-5-phosphate 2.01Å AUTH Q.LIU,I.A.KRIKSUNOV,H.JIANG,R.GRAEFF,H.LIN,H.C.LEE,Q.HAOTITL COVALENT AND NONCOVALENT INTERMEDIATES OF AN NAD UTILIZINGTITL 2 ENZYME, HUMAN CD38.REF CHEM.BIOL. V. 15 1068 2008REFN ISSN 1074-5521PMID 18940667DOI 10.1016/J.CHEMBIOL.2008.08.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ezq FAS crystal structure of the fas/fadd death domain complex 2.73Å AUTH F.L.SCOTT,B.STEC,C.POP,M.K.DOBACZEWSKA,J.J.LEE,E.MONOSOV,AUTH 2 H.ROBINSON,G.S.SALVESEN,R.SCHWARZENBACHER,S.J.RIEDLTITL THE FAS-FADD DEATH DOMAIN COMPLEX STRUCTURE UNRAVELSTITL 2 SIGNALLING BY RECEPTOR CLUSTERINGREF NATURE V. 457 1019 2009REFN ISSN 0028-0836PMID 19118384DOI 10.1038/NATURE07606 Variant Set Distributions Mapped Variants
General Structure Information 3hei EFNA1 ligand recognition by a-class eph receptors: crystal structures of the epha2 ligand-binding domain and the epha2/ephrin-a1 complex 2.0Å AUTH J.P.HIMANEN,Y.GOLDGUR,H.MIAO,E.MYSHKIN,H.GUO,M.BUCK,AUTH 2 M.NGUYEN,K.R.RAJASHANKAR,B.WANG,D.B.NIKOLOVTITL LIGAND RECOGNITION BY A-CLASS EPH RECEPTORS: CRYSTALTITL 2 STRUCTURES OF THE EPHA2 LIGAND-BINDING DOMAIN AND THETITL 3 EPHA2/EPHRIN-A1 COMPLEX.REF EMBO REP. V. 10 722 2009REFN ISSN 1469-221XPMID 19525919DOI […]
General Structure Information 1ef1 MSN crystal structure of the moesin ferm domain/tail domain complex 1.9Å AUTH M.A.PEARSON,D.RECZEK,A.BRETSCHER,P.A.KARPLUSTITL STRUCTURE OF THE ERM PROTEIN MOESIN REVEALS THE FERM DOMAINTITL 2 FOLD MASKED BY AN EXTENDED ACTIN BINDING TAIL DOMAIN.REF CELL(CAMBRIDGE,MASS.) V. 101 259 2000REFN ISSN 0092-8674PMID 10847681DOI 10.1016/S0092-8674(00)80836-3 Variant Set Distributions Mapped Variants
General Structure Information 3i8v PDE4A crystal structure of human pde4a with 4-(3-butoxy-4-methoxyphenyl) methyl-2-imidazolidone 2.25Å AUTH R.K.Y.CHENG,L.CRAWLEY,J.BARKER,M.WOOD,B.FELICETTI,AUTH 2 M.WHITTAKERTITL CRYSTAL STRUCTURE OF HUMAN PDE4A WITHTITL 2 4-(3-BUTOXY-4-METHOXYPHENYL)METHYL-2-IMIDAZOLIDONEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ici PPIB crystal structure of cyclophilin b in complex with calmegin fragment 1.7Å AUTH G.KOZLOV,S.BASTOS-ARISTIZABAL,P.MAATTANEN,A.ROSENAUER,AUTH 2 F.ZHENG,A.KILLIKELLY,J.F.TREMPE,D.Y.THOMAS,K.GEHRINGTITL STRUCTURAL BASIS OF CYCLOPHILIN B BINDING BY THETITL 2 CALNEXIN/CALRETICULIN P-DOMAIN.REF J.BIOL.CHEM. V. 285 35551 2010REFN ISSN 0021-9258PMID 20801878DOI 10.1074/JBC.M110.160101 Variant Set Distributions Mapped Variants
General Structure Information 3kka EPHA1 co-crystal structure of the sam domains of epha1 and epha2 2.4Å AUTH J.R.WALKER,L.YERMEKBAYEVA,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL CO-CRYSTAL STRUCTURE OF THE SAM DOMAINS OF HUMANTITL 2 EPHRIN TYPE-A RECEPTOR 1 AND HUMAN EPHRIN TYPE-ATITL 3 RECEPTOR 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3jxh PTPRG ca-like domain of human ptprg 1.7Å AUTH S.BOUYAIN,D.J.WATKINSTITL THE PROTEIN TYROSINE PHOSPHATASES PTPRZ AND PTPRGTITL 2 BIND TO DISTINCT MEMBERS OF THE CONTACTIN FAMILY OFTITL 3 NEURAL RECOGNITION MOLECULES.REF PROC.NATL.ACAD.SCI.USA V. 107 2443 2010REFN ISSN 0027-8424PMID 20133774DOI 10.1073/PNAS.0911235107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants