Assessment of Structural Intolerance and Durability
General Structure Information 4ddp BECN1 crystal structure of beclin 1 evolutionarily conserved domain(ecd) 1.55Å AUTH W.HUANG,W.CHOI,W.HU,N.MI,Q.GUO,M.MA,M.LIU,Y.TIAN,P.LU,AUTH 2 F.L.WANG,H.DENG,L.LIU,N.GAO,L.YU,Y.SHITITL CRYSTAL STRUCTURE AND BIOCHEMICAL ANALYSES REVEAL BECLIN 1TITL 2 AS A NOVEL MEMBRANE BINDING PROTEINREF CELL RES. 2012REFN ISSN 1001-0602PMID 22310240DOI 10.1038/CR.2012.24 Variant Set Distributions Mapped Variants
General Structure Information 1joc EEA1 eea1 homodimer of c-terminal fyve domain bound to inositol 1,3-diphosphate 2.2Å AUTH J.J.DUMAS,E.MERITHEW,E.SUDHARSHAN,D.RAJAMANI,AUTH 2 S.HAYES,D.LAWE,S.CORVERA,D.G.LAMBRIGHTTITL MULTIVALENT ENDOSOME TARGETING BY HOMODIMERIC EEA1.REF MOL.CELL V. 8 947 2001REFN ISSN 1097-2765PMID 11741531DOI 10.1016/S1097-2765(01)00385-9 Variant Set Distributions Mapped Variants
General Structure Information 3bbt ERBB4 crystal structure of the erbb4 kinase in complex with lapatinib 2.8Å AUTH C.QIU,M.K.TARRANT,S.H.CHOI,A.SATHYAMURTHY,R.BOSE,S.BANJADE,AUTH 2 A.PAL,W.G.BORNMANN,M.A.LEMMON,P.A.COLE,D.J.LEAHYTITL MECHANISM OF ACTIVATION AND INHIBITION OF THE HER4/ERBB4TITL 2 KINASE.REF STRUCTURE V. 16 460 2008REFN ISSN 0969-2126PMID 18334220DOI 10.1016/J.STR.2007.12.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3hrn PKD2 crystal structure of a c-terminal coiled coil domain of transient receptor potential (trp) channel subfamily p member 2 (trpp2, polycystic kidney disease 2) 1.9Å AUTH Y.YU,M.H.ULBRICH,M.H.LI,Z.BURAEI,X.Z.CHEN,A.C.ONG,AUTH 2 L.TONG,E.Y.ISACOFF,J.YANGTITL STRUCTURAL AND MOLECULAR BASIS OF THE ASSEMBLY OFTITL 2 THE TRPP2/PKD1 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 106 11558 2009REFN ISSN 0027-8424PMID 19556541DOI 10.1073/PNAS.0903684106 Variant […]
General Structure Information 3f7p PLEC crystal structure of a complex between integrin beta4 and plectin 2.75Å AUTH J.M.DE PEREDA,M.P.LILLO,A.SONNENBERGTITL STRUCTURAL BASIS OF THE INTERACTION BETWEENTITL 2 INTEGRIN ALPHA6BETA4 AND PLECTIN AT THETITL 3 HEMIDESMOSOMESREF EMBO J. V. 28 1180 2009REFN ISSN 0261-4189PMID 19242489DOI 10.1038/EMBOJ.2009.48 Variant Set Distributions Mapped Variants
General Structure Information 2z7x TLR1 crystal structure of the tlr1-tlr2 heterodimer induced by binding of a tri-acylated lipopeptide 2.1Å AUTH M.S.JIN,S.E.KIM,J.Y.HEO,M.E.LEE,H.M.KIM,S.G.PAIK,H.LEE,AUTH 2 J.O.LEETITL CRYSTAL STRUCTURE OF THE TLR1-TLR2 HETERODIMER INDUCED BYTITL 2 BINDING OF A TRI-ACYLATED LIPOPEPTIDEREF CELL(CAMBRIDGE,MASS.) V. 130 1071 2007REFN ISSN 0092-8674PMID 17889651DOI 10.1016/J.CELL.2007.09.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2ke4 TRIP10 the nmr structure of the tc10 and cdc42 interacting domain of cip4 -1.0Å AUTH Y.KOBASHIGAWA,H.KUMETA,D.KANOH,F.INAGAKITITL THE NMR STRUCTURE OF THE TC10- ANDTITL 2 CDC42-INTERACTING DOMAIN OF CIP4.REF J.BIOMOL.NMR V. 44 113 2009REFN ISSN 0925-2738PMID 19387844DOI 10.1007/S10858-009-9317-Z Variant Set Distributions Mapped Variants
General Structure Information 2e7k MPP2 solution structure of the pdz domain from human maguk p55 subfamily member 2 -1.0Å AUTH X.R.QIN,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PDZ DOMAIN FROM HUMANTITL 2 MAGUK P55 SUBFAMILY MEMBER 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2e7k MPP2 solution structure of the pdz domain from human maguk p55 subfamily member 2 -1.0Å AUTH X.R.QIN,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PDZ DOMAIN FROM HUMANTITL 2 MAGUK P55 SUBFAMILY MEMBER 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3n1p IHH crystal structure of ihhn bound to bocfn3 2.7Å AUTH J.M.KAVRAN,M.D.WARD,O.O.OLADOSU,S.MULEPATI,D.J.LEAHYTITL ALL MAMMALIAN HEDGEHOG PROTEINS INTERACT WITH CDO AND BOCTITL 2 IN A CONSERVED MANNER.REF J.BIOL.CHEM. 2010REFN ESSN 1083-351XPMID 20519495DOI 10.1074/JBC.M110.131680 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants