Assessment of Structural Intolerance and Durability
General Structure Information 2v0o FCHO2 fcho2 f-bar domain 2.3Å AUTH W.M.HENNE,H.M.KENT,M.J.G.FORD,B.G.HEDGE,O.DAUMKE,AUTH 2 P.J.BUTLER,R.MITTAL,R.LANGEN,P.R.EVANS,H.T.MCMAHONTITL STRUCTURE AND ANALYSIS OF FCHO2 F-BAR DOMAIN: ATITL 2 DIMERIZING AND MEMBRANE RECRUITMENT MODULE THATTITL 3 EFFECTS MEMBRANE CURVATURE.REF STRUCTURE V. 15 839 2007REFN ISSN 0969-2126PMID 17540576DOI 10.1016/J.STR.2007.05.002 Variant Set Distributions Mapped Variants
General Structure Information 4gnk PLCB3 crystal structure of galphaq in complex with full-length human plcbeta3 4.0Å AUTH A.M.LYON,S.DUTTA,C.A.BOGUTH,G.SKINIOTIS,J.J.TESMERTITL FULL-LENGTH G ALPHA (Q)-PHOSPHOLIPASE C-BETA 3 STRUCTURETITL 2 REVEALS INTERFACES OF THE C-TERMINAL COILED-COIL DOMAIN.REF NAT.STRUCT.MOL.BIOL. V. 20 355 2013REFN ISSN 1545-9993PMID 23377541DOI 10.1038/NSMB.2497 Variant Set Distributions Mapped Variants
General Structure Information 4gnk PLCB3 crystal structure of galphaq in complex with full-length human plcbeta3 4.0Å AUTH A.M.LYON,S.DUTTA,C.A.BOGUTH,G.SKINIOTIS,J.J.TESMERTITL FULL-LENGTH G ALPHA (Q)-PHOSPHOLIPASE C-BETA 3 STRUCTURETITL 2 REVEALS INTERFACES OF THE C-TERMINAL COILED-COIL DOMAIN.REF NAT.STRUCT.MOL.BIOL. V. 20 355 2013REFN ISSN 1545-9993PMID 23377541DOI 10.1038/NSMB.2497 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4or2 GRM1 human class c g protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator 2.8Å AUTH H.WU,C.WANG,K.J.GREGORY,G.W.HAN,H.P.CHO,Y.XIA,C.M.NISWENDER,AUTH 2 V.KATRITCH,J.MEILER,V.CHEREZOV,P.J.CONN,R.C.STEVENSTITL STRUCTURE OF A CLASS C GPCR METABOTROPIC GLUTAMATE RECEPTORTITL 2 1 BOUND TO AN ALLOSTERIC MODULATORREF SCIENCE V. 344 58 2014REFN ISSN 0036-8075PMID 24603153DOI 10.1126/SCIENCE.1249489 Variant Set Distributions Ripley’s […]
General Structure Information 4or2 GRM1 human class c g protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator 2.8Å AUTH H.WU,C.WANG,K.J.GREGORY,G.W.HAN,H.P.CHO,Y.XIA,C.M.NISWENDER,AUTH 2 V.KATRITCH,J.MEILER,V.CHEREZOV,P.J.CONN,R.C.STEVENSTITL STRUCTURE OF A CLASS C GPCR METABOTROPIC GLUTAMATE RECEPTORTITL 2 1 BOUND TO AN ALLOSTERIC MODULATORREF SCIENCE V. 344 58 2014REFN ISSN 0036-8075PMID 24603153DOI 10.1126/SCIENCE.1249489 Variant Set Distributions Ripley’s […]
General Structure Information 4or2 GRM1 human class c g protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator 2.8Å AUTH H.WU,C.WANG,K.J.GREGORY,G.W.HAN,H.P.CHO,Y.XIA,C.M.NISWENDER,AUTH 2 V.KATRITCH,J.MEILER,V.CHEREZOV,P.J.CONN,R.C.STEVENSTITL STRUCTURE OF A CLASS C GPCR METABOTROPIC GLUTAMATE RECEPTORTITL 2 1 BOUND TO AN ALLOSTERIC MODULATORREF SCIENCE V. 344 58 2014REFN ISSN 0036-8075PMID 24603153DOI 10.1126/SCIENCE.1249489 Variant Set Distributions Ripley’s […]
General Structure Information 3q90 G3BP1 crystal structure of the ntf2 domain of ras gtpase-activating protein- binding protein 1 1.7Å AUTH M.WELIN,L.TRESAUGUES,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,T.EKBLAD,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,T.KOTENYOVA,AUTH 4 E.KOUZNETSOVA,M.MOCHE,T.NYMAN,C.PERSSON,H.SCHULER,P.SCHUTZ,AUTH 5 M.I.SIPONEN,A.G.THORSELL,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,P.NORDLUNDTITL CRYSTAL STRUCTURE OF THE NTF2 DOMAIN OF RASTITL 2 GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3bxm FOLH1 structure of an inactive mutant of human glutamate carboxypeptidase ii [gcpii(e424a)] in complex with n-acetyl-asp-glu (naag) 1.71Å AUTH V.KLUSAK,C.BARINKA,A.PLECHANOVOVA,P.MLCOCHOVA,J.KONVALINKA,AUTH 2 L.RULISEK,J.LUBKOWSKITITL REACTION MECHANISM OF GLUTAMATE CARBOXYPEPTIDASE II REVEALEDTITL 2 BY MUTAGENESIS, X-RAY CRYSTALLOGRAPHY, AND COMPUTATIONALTITL 3 METHODS.REF BIOCHEMISTRY V. 48 4126 2009REFN ISSN 0006-2960PMID 19301871DOI 10.1021/BI900220S Variant Set Distributions Ripley’s […]
General Structure Information 4gt4 ROR2 structure of unliganded, inactive ror2 kinase domain 2.41Å AUTH S.C.ARTIM,J.M.MENDROLA,M.A.LEMMONTITL ASSESSING THE RANGE OF KINASE AUTOINHIBITION MECHANISMS INTITL 2 THE INSULIN RECEPTOR FAMILY.REF BIOCHEM.J. V. 448 213 2012REFN ISSN 0264-6021PMID 22992069DOI 10.1042/BJ20121365 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bpr MERTK crystal structure of catalytic domain of the proto-oncogene tyrosine- protein kinase mer in complex with inhibitor c52 2.8Å AUTH X.HUANG,P.FINERTY,J.R.WALKER,C.BUTLER-COLE,M.VEDADI,AUTH 2 M.SCHAPIRA,S.A.PARKER,B.E.TURK,D.A.THOMPSON,S.DHE-PAGANONTITL STRUCTURAL INSIGHTS INTO THE INHIBITED STATES OF THE MERTITL 2 RECEPTOR TYROSINE KINASE.REF J.STRUCT.BIOL. V. 165 88 2009REFN ISSN 1047-8477PMID 19028587DOI 10.1016/J.JSB.2008.10.003 Variant Set Distributions Ripley’s K Analysis […]