Assessment of Structural Intolerance and Durability
General Structure Information 2k3w VPS4A nmr structure of vps4a-mit-chmp6 -1.0Å AUTH C.KIEFFER,J.J.SKALICKY,E.MORITA,I.DE DOMENICO,AUTH 2 D.M.WARD,J.KAPLAN,W.I.SUNDQUISTTITL TWO DISTINCT MODES OF ESCRT-III RECOGNITION ARETITL 2 REQUIRED FOR VPS4 FUNCTIONS IN LYSOSOMAL PROTEINTITL 3 TARGETING AND HIV-1 BUDDINGREF DEV.CELL V. 15 62 2008REFN ISSN 1534-5807PMID 18606141DOI 10.1016/J.DEVCEL.2008.05.014 Variant Set Distributions Mapped Variants
General Structure Information 2c5l PLCE1 structure of plc epsilon ras association domain with hras 1.9Å AUTH T.D.BUNNEY,R.HARRIS,N.L.GANDARILLAS,M.B.JOSEPHS,AUTH 2 S.M.ROE,S.C.SORLI,H.F.PATERSON,F.RODRIGUES-LIMA,AUTH 3 D.ESPOSITO,C.P.PONTING,P.GIESCHIK,L.H.PEARL,AUTH 4 P.C.DRISCOLL,M.KATANTITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO RASTITL 2 ASSOCIATION DOMAINS OF PHOSPHOLIPASE C EPSILONREF MOL.CELL V. 21 495 2006REFN ISSN 1097-2765PMID 16483931DOI 10.1016/J.MOLCEL.2006.01.008 Variant Set Distributions Mapped Variants
General Structure Information 3bc1 SYTL2 crystal structure of the complex rab27a-slp2a 1.8Å AUTH L.M.G.CHAVAS,K.IHARA,M.KAWASAKI,S.TORII,T.UEJIMA,R.KATO,AUTH 2 T.IZUMI,S.WAKATSUKITITL ELUCIDATION OF RAB27 RECRUITMENT BY ITS EFFECTORS: STRUCTURETITL 2 OF RAB27A BOUND TO EXOPHILIN4/SLP2-AREF STRUCTURE V. 16 1468 2008REFN ISSN 0969-2126PMID 18940603DOI 10.1016/J.STR.2008.07.015 Variant Set Distributions Mapped Variants
General Structure Information 2jam CAMK1G crystal structure of human calmodulin-dependent protein kinase i g 1.7Å AUTH J.E.DEBRECZENI,A.BULLOCK,T.KEATES,F.H.NIESEN,AUTH 2 E.SALAH,L.SHRESTHA,C.SMEE,F.SOBOTT,A.C.W.PIKE,AUTH 3 G.BUNKOCZI,F.VON DELFT,A.TURNBULL,J.WEIGELT,AUTH 4 C.H.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENTTITL 2 PROTEIN KINASE I GREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wmn DOCK9 structure of the complex between dock9 and cdc42-gdp. 2.39Å AUTH J.YANG,Z.ZHANG,S.M.ROE,C.J.MARSHALL,D.BARFORDTITL ACTIVATION OF RHO GTPASES BY DOCK EXCHANGE FACTORSTITL 2 IS MEDIATED BY A NUCLEOTIDE SENSOR.REF SCIENCE V. 325 1398 2009REFN ISSN 0036-8075PMID 19745154DOI 10.1126/SCIENCE.1174468 Variant Set Distributions Mapped Variants
General Structure Information 2r02 PDCD6IP crystal structure of alix/aip1 in complex with the hiv-1 ypltsl late domain 2.6Å AUTH Q.ZHAI,R.D.FISHER,H.Y.CHUNG,D.G.MYSZKA,AUTH 2 W.I.SUNDQUIST,C.P.HILLTITL STRUCTURAL AND FUNCTIONAL STUDIES OF ALIXTITL 2 INTERACTIONS WITH YPX(N)L LATE DOMAINS OF HIV-1TITL 3 AND EIAV.REF NAT.STRUCT.MOL.BIOL. V. 15 43 2008REFN ISSN 1545-9993PMID 18066081DOI 10.1038/NSMB1319 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2dm4 SORL1 solution structure of the second fn3 domain of human sorla/lr11 -1.0Å AUTH T.NAGASHIMA,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND FN3 DOMAIN OFTITL 2 HUMAN SORLA/LR11REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2rex RND1 crystal structure of the effector domain of plxnb1 bound with rnd1 gtpase 2.3Å AUTH Y.TONG,W.TEMPEL,L.SHEN,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE EFFECTOR DOMAIN OF PLXNB1 BOUNDTITL 2 WITH RND1 GTPASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bbp GCC2 rab6-gtp:gcc185 rab binding domain complex 3.0Å AUTH A.S.BURGUETE,T.D.FENN,A.T.BRUNGER,S.R.PFEFFERTITL RAB AND ARL GTPASE FAMILY MEMBERS COOPERATE IN THETITL 2 LOCALIZATION OF THE GOLGIN GCC185.REF CELL(CAMBRIDGE,MASS.) V. 132 286 2008REFN ISSN 0092-8674PMID 18243103DOI 10.1016/J.CELL.2007.11.048 Variant Set Distributions Mapped Variants
General Structure Information 2rgn ARHGEF25 crystal structure of p63rhogef complex with galpha-q and rhoa 3.5Å AUTH S.LUTZ,A.SHANKARANARAYANAN,C.COCO,M.RIDILLA,M.R.NANCE,AUTH 2 C.VETTEL,D.BALTUS,C.R.EVELYN,R.R.NEUBIG,T.WIELAND,J.J.TESMERTITL STRUCTURE OF GALPHAQ-P63RHOGEF-RHOA COMPLEX REVEALS ATITL 2 PATHWAY FOR THE ACTIVATION OF RHOA BY GPCRS.REF SCIENCE V. 318 1923 2007REFN ISSN 0036-8075PMID 18096806DOI 10.1126/SCIENCE.1147554 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]