Assessment of Structural Intolerance and Durability
General Structure Information 2d9x OSBPL11 solution structure of the ph domain of oxysterol binding protein-related protein 11 from human -1.0Å AUTH H.LI,M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF OXYSTEROLTITL 2 BINDING PROTEIN-RELATED PROTEIN 11 FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1v88 OSBPL8 solution structure of the pleckstrin homology domain of oxysterol-binding protein-related protein 8 (kiaa1451 protein) -1.0Å AUTH H.LI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PLECKSTRIN HOMOLOGYTITL 2 DOMAIN OF OXYSTEROL-BINDING PROTEIN-RELATEDTITL 3 PROTEIN 8 (KIAA1451 PROTEIN)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3b7k ACOT12 human acyl-coenzyme a thioesterase 12 2.7Å AUTH L.LEHTIO,R.D.BUSAM,C.H.ARROWSMITH,R.COLLINS,L.G.DAHLGREN,AUTH 2 A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,AUTH 3 B.M.HALLBERG,M.D.HERMAN,A.JOHANSSON,I.JOHANSSON,A.KALLAS,AUTH 4 T.KARLBERG,T.KOTENYOVA,M.MOCHE,M.E.NILSSON,P.NORDLUND,AUTH 5 T.NYMAN,C.PERSSON,J.SAGEMARK,M.SUNDSTROM,SVENSSON L.,AUTH 6 A.G.THORSELL,L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,AUTH 7 H.BERGLUNDTITL HUMAN ACYL-COENZYME A THIOESTERASE 12.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vx2 ECHDC3 crystal structure of human enoyl coenzyme a hydratase domain-containing protein 3 (echdc3) 2.3Å AUTH W.W.YUE,K.GUO,G.KOCHAN,E.PILKA,J.W.MURRAY,E.SALAH,R.COCKING,AUTH 2 Z.SUN,A.K.ROOS,A.C.W.PIKE,P.FILIPPAKOPOULOS,C.ARROWSMITH,AUTH 3 M.WIKSTROM,A.EDWARDS,C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN ENOYL COENZYME A HYDRATASETITL 2 DOMAIN-CONTAINING PROTEIN 3 (ECHDC3)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3fo5 ACOT11 human start domain of acyl-coenzyme a thioesterase 11 (acot11) 2.0Å AUTH A.G.THORSELL,W.H.LEE,C.PERSSON,M.I.SIPONEN,M.NILSSON,AUTH 2 R.D.BUSAM,T.KOTENYOVA,H.SCHULER,L.LEHTIOTITL COMPARATIVE STRUCTURAL ANALYSIS OF LIPID BINDING STARTTITL 2 DOMAINS.REF PLOS ONE V. 6 19521 2011REFN ESSN 1932-6203PMID 21738568DOI 10.1371/JOURNAL.PONE.0019521 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2dm4 SORL1 solution structure of the second fn3 domain of human sorla/lr11 -1.0Å AUTH T.NAGASHIMA,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND FN3 DOMAIN OFTITL 2 HUMAN SORLA/LR11REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3fdw SYTL4 crystal structure of a c2 domain from human synaptotagmin- like protein 4 2.2Å AUTH J.B.BONANNO,M.RUTTER,K.T.BAIN,S.MILLER,R.ROMERO,AUTH 2 S.WASSERMAN,J.M.SAUDER,S.K.BURLEY,S.C.ALMOTITL CRYSTAL STRUCTURE OF A C2 DOMAIN FROM HUMANTITL 2 SYNAPTOTAGMIN-LIKE PROTEIN 4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2pd6 HSD17B8 structure of human hydroxysteroid dehydrogenase type 8, hsd17b8 2.0Å AUTH A.P.TURNBULL,E.SALAH,O.GILEADI,P.SAVITSKY,K.GUO,G.BUNKOCZI,AUTH 2 A.C.W.PIKE,E.UGOCHUKWU,C.UMEANO,F.VON DELFT,J.WEIGELT,AUTH 3 C.H.ARROWSMITH,M.SUNDSTROM,A.EDWARDS,U.OPPERMANN,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL STRUCTURE OF HUMAN HYDROXYSTEROID DEHYDROGENASE TYPE 8,TITL 2 HSD17B8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2wh5 ACBD4 crystal structure of human acyl-coa binding domain 4 complexed with stearoyl-coa 2.6Å AUTH N.SHAFQAT,W.W.YUE,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN ACYL-COA BINDING DOMAINTITL 2 4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2z0u WWC1 crystal structure of c2 domain of kibra protein 2.2Å AUTH K.MURAYAMA,M.KATO-MURAYAMA,T.TERADA,M.SHIROUZU,AUTH 2 S.YOKOYAMATITL CRYSTAL STRUCTURE OF C2 DOMAIN OF KIBRA PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants