Assessment of Structural Intolerance and Durability
General Structure Information 3bg3 PC crystal structure of human pyruvate carboxylase (missing the biotin carboxylase domain at the n-terminus) 2.8Å AUTH S.XIANG,L.TONGTITL CRYSTAL STRUCTURES OF HUMAN AND STAPHYLOCOCCUSTITL 2 AUREUS PYRUVATE CARBOXYLASE AND MOLECULAR INSIGHTSTITL 3 INTO THE CARBOXYLTRANSFER REACTION.REF NAT.STRUCT.MOL.BIOL. V. 15 295 2008REFN ISSN 1545-9993PMID 18297087DOI 10.1038/NSMB.1393 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1fyj EPRS solution structure of multi-functional peptide motif-1 present in human glutamyl-prolyl trna synthetase (eprs). -1.0Å AUTH E.J.JEONG,G.S.HWANG,K.H.KIM,M.J.KIM,S.KIM,K.S.KIMTITL STRUCTURAL ANALYSIS OF MULTIFUNCTIONAL PEPTIDETITL 2 MOTIFS IN HUMAN BIFUNCTIONAL TRNA SYNTHETASE:TITL 3 IDENTIFICATION OF RNA-BINDING RESIDUES ANDTITL 4 FUNCTIONAL IMPLICATIONS FOR TANDEM REPEATS.REF BIOCHEMISTRY V. 39 15775 2000REFN ISSN 0006-2960PMID 11123902DOI 10.1021/BI001393H Variant […]
General Structure Information 2keo HERC2 solution nmr structure of human protein hs00059, cytochrome-b5-like domain of the herc2 e3 ligase. northeast structural genomics consortium (nesg) target ht98a -1.0Å AUTH A.LEMAK,A.GUTMANAS,C.FARES,H.QUYANG,Y.LI,G.MONTELIONE,AUTH 2 C.ARROWSMITH,S.DHE-PAGANONTITL SOLUTION NMR STRUCTURE OF HUMAN PROTEIN HS00059REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2nz2 ASS1 crystal structure of human argininosuccinate synthase in complex with aspartate and citrulline 2.4Å AUTH T.KARLBERG,R.COLLINS,S.VAN DEN BERG,A.FLORES,M.HAMMARSTROM,AUTH 2 M.HOGBOM,L.HOLMBERG SCHIAVONE,J.UPPENBERGTITL STRUCTURE OF HUMAN ARGININOSUCCINATE SYNTHETASE.REF ACTA CRYSTALLOGR.,SECT.D V. 64 279 2008REFN ISSN 0907-4449PMID 18323623DOI 10.1107/S0907444907067455 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4l1m HERC2 structure of the first rcc1-like domain of herc2 2.6Å AUTH W.TEMPEL,M.B.KHAN,A.DONG,J.HU,Y.LI,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,Y.TONGTITL STRUCTURE OF THE FIRST RCC1-LIKE DOMAIN OF HERC2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2cqy PCCA solution structure of b domain from human propionyl-coa carboxylase alpha subunit -1.0Å AUTH T.SUETAKE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF B DOMAIN FROM HUMANTITL 2 PROPIONYL-COA CARBOXYLASE ALPHA SUBUNITREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3kci HERC2 the third rld domain of herc2 1.8Å AUTH J.R.WALKER,L.QIU,A.VESTERBERG,J.WEIGELT,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL STRUCTURE OF THE THIRD RLD DOMAIN OF HERC2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3lrq TRIM37 crystal structure of the u-box domain of human ubiquitin- protein ligase (e3), northeast structural genomics consortium target hr4604d. 2.29Å AUTH A.KUZIN,Y.CHEN,J.SEETHARAMAN,M.MAO,R.XIAO,AUTH 2 C.CICCOSANTI,R.SHASTRY,J.K.EVERETT,R.NAIR,AUTH 3 T.B.ACTON,B.ROST,G.T.MONTELIONE,L.TONG,J.F.HUNTTITL E3 UBIQUITIN-PROTEIN LIGASE RING DOMAIN FROM HUMANTITL 2 TRIPARTITE MOTIF-CONTAINING PROTEIN 37 (TRIM37),TITL 3 NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGETTITL 4 HR4604D.REF TO BE PUBLISHEDREFN Variant […]
General Structure Information 2csw RNF8 solution structure of the fha domain of human ubiquitin ligase protein rnf8 -1.0Å AUTH F.HAYASHI,T.NAGASHIMA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FHA DOMAIN OF HUMANTITL 2 UBIQUITIN LIGASE PROTEIN RNF8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4fo9 PIAS2 crystal structure of the e3 sumo ligase pias2 2.39Å AUTH J.HU,A.DONG,E.DOBROVETSKY,W.TEMPEL,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,Y.TONG,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE E3 SUMO LIGASE PIAS2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants