Assessment of Structural Intolerance and Durability
General Structure Information 3zni CBLB structure of phosphotyr363-cbl-b – ubch5b-ub – zap-70 peptide complex 2.21Å AUTH H.DOU,L.BUETOW,G.J.SIBBET,K.CAMERON,D.T.HUANGTITL ESSENTIALITY OF A NON-RING ELEMENT IN PRIMING DONORTITL 2 UBIQUITIN FOR CATALYSIS BY A MONOMERIC E3.REF NAT.STRUCT.MOL.BIOL. V. 20 982 2013REFN ISSN 1545-9993PMID 23851457DOI 10.1038/NSMB.2621 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1fqv SKP2 insights into scf ubiquitin ligases from the structure of the skp1-skp2 complex 2.8Å AUTH B.A.SCHULMAN,A.C.CARRANO,P.D.JEFFREY,Z.BOWEN,AUTH 2 E.R.KINNUCAN,M.S.FINNIN,S.J.ELLEDGE,J.W.HARPER,AUTH 3 M.PAGANO,N.P.PAVLETICHTITL INSIGHTS INTO SCF UBIQUITIN LIGASES FROM THETITL 2 STRUCTURE OF THE SKP1-SKP2 COMPLEX.REF NATURE V. 408 381 2000REFN ISSN 0028-0836PMID 11099048DOI 10.1038/35042620 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1d5f UBE3A structure of an e6ap-ubch7 complex: insights into the ubiquitination pathway 2.8Å AUTH L.HUANG,E.KINNUCAN,G.WANG,S.BEAUDENON,P.M.HOWLEY,AUTH 2 J.M.HUIBREGTSE,N.P.PAVLETICHTITL STRUCTURE OF AN E6AP-UBCH7 COMPLEX: INSIGHTS INTOTITL 2 UBIQUITINATION BY THE E2-E3 ENZYME CASCADE.REF SCIENCE V. 286 1321 1999REFN ISSN 0036-8075PMID 10558980DOI 10.1126/SCIENCE.286.5443.1321 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1y8x UBE2M structural basis for recruitment of ubc12 by an e2-binding domain in nedd8s e1 2.4Å AUTH D.T.HUANG,A.PAYDAR,M.ZHUANG,M.B.WADDELL,J.M.HOLTON,AUTH 2 B.A.SCHULMANTITL STRUCTURAL BASIS FOR RECRUITMENT OF UBC12 BY AN E2TITL 2 BINDING DOMAIN IN NEDD8S E1.REF MOL.CELL V. 17 341 2005REFN ISSN 1097-2765PMID 15694336DOI 10.1016/J.MOLCEL.2004.12.020 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2c6b MDM2 solution structure of the c4 zinc-finger domain of hdm2 -1.0Å AUTH G.W.YU,M.D.ALLEN,A.ANDREEVA,A.R.FERSHT,M.BYCROFTTITL SOLUTION STRUCTURE OF THE C4 ZINC FINGER DOMAIN OFTITL 2 HDM2.REF PROTEIN SCI. V. 15 384 2006REFN ISSN 0961-8368PMID 16385008DOI 10.1110/PS.051927306 Variant Set Distributions Mapped Variants
General Structure Information 2kna XIAP solution structure of uba domain of xiap -1.0Å AUTH S.K.HUI,M.K.TSE,Y.YANG,B.C.WONG,K.H.SZETITL BACKBONE AND SIDE-CHAIN 1H, 13C AND 15N ASSIGNMENTS OF THETITL 2 UBIQUITIN-ASSOCIATED DOMAIN OF HUMAN X-LINKED INHIBITOR OFTITL 3 APOPTOSIS PROTEINREF BIOMOL.NMR ASSIGN. V. 4 13 2010REFN ISSN 1874-2718PMID 19916060DOI 10.1007/S12104-009-9197-X Variant Set Distributions Mapped Variants
General Structure Information 3l1z UBE2D3 crystal structure of the u-box domain of human e4b ubiquitin ligase in complex with ubch5c e2 ubiquitin conjugating enzyme 3.17Å AUTH R.C.BENIRSCHKE,J.R.THOMPSON,Y.NOMINE,E.WASIELEWSKI,AUTH 2 N.JURANIC,S.MACURA,S.HATAKEYAMA,K.I.NAKAYAMA,M.V.BOTUYAN,AUTH 3 G.MERTITL MOLECULAR BASIS FOR THE ASSOCIATION OF HUMAN E4B U BOXTITL 2 UBIQUITIN LIGASE WITH E2-CONJUGATING ENZYMES UBCH5C ANDTITL 3 UBC4.REF STRUCTURE V. 18 955 […]
General Structure Information 4f52 RBX1 structure of a glomulin-rbx1-cul1 complex 3.0Å AUTH D.M.DUDA,J.L.OLSZEWSKI,A.E.TRON,M.HAMMEL,L.J.LAMBERT,AUTH 2 M.B.WADDELL,T.MITTAG,J.A.DECAPRIO,B.A.SCHULMANTITL STRUCTURE OF A GLOMULIN-RBX1-CUL1 COMPLEX: INHIBITION OF ATITL 2 RING E3 LIGASE THROUGH MASKING OF ITS E2-BINDING SURFACE.REF MOL.CELL V. 47 371 2012REFN ISSN 1097-2765PMID 22748924DOI 10.1016/J.MOLCEL.2012.05.044 Variant Set Distributions Mapped Variants
General Structure Information 3k9p UBE2K the crystal structure of e2-25k and ubiquitin complex 2.8Å AUTH S.KO,G.B.KANG,S.M.SONG,J.-G.LEE,D.Y.SHIN,J.-H.YUN,Y.SHENG,AUTH 2 C.CHEONG,Y.H.JEON,Y.-K.JUNG,C.H.ARROWSMITH,G.V.AVVAKUMOV,AUTH 3 S.DHE-PAGANON,Y.J.YOO,S.H.EOM,W.LEETITL STRUCTURAL BASIS OF E2-25K/UBB+1 INTERACTION LEADING TOTITL 2 PROTEASOME INHIBITION AND NEUROTOXICITYREF J.BIOL.CHEM. V. 285 36070 2010REFN ISSN 0021-9258PMID 20826778DOI 10.1074/JBC.M110.145219 Variant Set Distributions Mapped Variants
General Structure Information 2awf UBE2G1 structure of human ubiquitin-conjugating enzyme e2 g1 2.1Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants