Assessment of Structural Intolerance and Durability
General Structure Information 4dqm RARA revealing a marine natural product as a novel agonist for retinoic acid receptors with a unique binding mode and antitumor activity 2.75Å AUTH S.WANG,Z.WANG,S.LIN,W.ZHENG,R.WANG,S.JIN,J.CHEN,L.JIN,Y.LITITL REVEALING A NATURAL MARINE PRODUCT AS A NOVEL AGONIST FORTITL 2 RETINOIC ACID RECEPTORS WITH A UNIQUE BINDING MODE ANDTITL 3 INHIBITORY EFFECTS ON CANCER CELLS.REF […]
General Structure Information 3d24 ESRRA crystal structure of ligand-binding domain of estrogen- related receptor alpha (erralpha) in complex with the peroxisome proliferators-activated receptor coactivator- 1alpha box3 peptide (pgc-1alpha) 2.11Å AUTH H.GRESCHIK,M.ALTHAGE,R.FLAIG,Y.SATO,V.CHAVANT,AUTH 2 C.PELUSO-ILTIS,L.CHOULIER,P.CRONET,N.ROCHEL,AUTH 3 R.SCHULE,P.E.STROMSTEDT,D.MORASTITL COMMUNICATION BETWEEN THE ERR{ALPHA} HOMODIMERTITL 2 INTERFACE AND THE PGC-1{ALPHA} BINDING SURFACE VIATITL 3 THE HELIX 8-9 LOOP.REF J.BIOL.CHEM. V. […]
General Structure Information 4j5w NR1I2 crystal structure of the apo-pxr/rxralpha lbd heterotetramer complex 2.8Å AUTH B.D.WALLACE,L.BETTS,G.TALMAGE,R.M.POLLET,N.S.HOLMAN,AUTH 2 M.R.REDINBOTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE HUMAN NUCLEARTITL 2 XENOBIOTIC RECEPTOR PXR IN COMPLEX WITH RXRALPHA.REF J.MOL.BIOL. V. 425 2561 2013REFN ISSN 0022-2836PMID 23602807DOI 10.1016/J.JMB.2013.04.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]