Assessment of Structural Intolerance and Durability
General Structure Information 2vwi OXSR1 structure of the osr1 kinase, a hypertension drug target 2.15Å AUTH F.VILLA,M.DEAK,D.R.ALESSI,D.M.F.VAN AALTENTITL STRUCTURE OF THE OSR1 KINASE, A HYPERTENSION DRUG TARGET.REF PROTEINS V. 73 1082 2008REFN ISSN 0887-3585PMID 18831043DOI 10.1002/PROT.22238 Variant Set Distributions Mapped Variants
General Structure Information 3be1 ERBB2 dual specific bh1 fab in complex with the extracellular domain of her2/erbb-2 2.9Å AUTH J.BOSTROM,S.F.YU,D.KAN,B.A.APPLETON,C.V.LEE,K.BILLECI,W.MAN,AUTH 2 F.PEALE,S.ROSS,C.WIESMANN,G.FUHTITL VARIANTS OF THE ANTIBODY HERCEPTIN THAT INTERACT WITH HER2TITL 2 AND VEGF AT THE ANTIGEN BINDING SITEREF SCIENCE V. 323 1610 2009REFN ISSN 0036-8075PMID 19299620DOI 10.1126/SCIENCE.1165480 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4g0n RAF1 crystal structure of wt h-ras-gppnhp bound to the rbd of raf kinase 2.45Å AUTH S.K.FETICS,H.GUTERRES,B.M.KEARNEY,G.BUHRMAN,B.MA,R.NUSSINOV,AUTH 2 C.MATTOSTITL ALLOSTERIC EFFECTS OF THE ONCOGENIC RASQ61L MUTANT ONTITL 2 RAF-RBD.REF STRUCTURE V. 23 505 2015REFN ISSN 0969-2126PMID 25684575DOI 10.1016/J.STR.2014.12.017 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3lm0 STK17B crystal structure of human serine/threonine kinase 17b (stk17b) 2.35Å Variant Set Distributions Mapped Variants
General Structure Information 2wwe PIK3C2G crystal structure of the phox homology domain of human phosphoinositide-3-kinase-c2-gamma 1.25Å AUTH A.K.ROOS,L.TRESAUGUES,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 A.KALLAS,T.KARLBERG,T.KOTYENOVA,A.KOTZCH,P.KRAULIS,AUTH 5 N.MARKOVA,M.MOCHE,T.K.NIELSEN,T.NYMAN,C.PERSSON,AUTH 6 H.SCHULER,P.SCHUTZ,M.I.SIPONEN,L.SVENSSON,AUTH 7 A.G.THORSELL,S.VAN DEN BERG,E.WAHLBERG,J.WEIGELT,AUTH 8 M.WELIN,M.WISNIEWSKA,P.NORDLUND,AUTH 9 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE PHOX HOMOLOGY DOMAIN OFTITL 2 HUMAN PHOSPHOINOSITIDE-3-KINASE-C2-GAMMAREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 2buj STK16 crystal structure of the human serine-threonine kinase 16 in complex with staurosporine 2.6Å AUTH J.E.DEBRECZENI,J.ESWARAN,A.BULLOCK,P.FILIPPAKOPOULOS,AUTH 2 K.KAVANAGH,A.AMOS,O.FEDOROV,F.SOBOTT,L.J.BALL,F.VON DELFT,AUTH 3 C.ARROWSMITH,M.SUNDSTROM,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF THE HUMAN SERINE-THREONINE KINASE 16TITL 2 IN COMPLEX WITH STAUROSPORINEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2wo3 EFNA2 crystal structure of the epha4-ephrina2 complex 2.35Å AUTH T.A.BOWDEN,A.R.ARICESCU,J.E.NETTLESHIP,C.SIEBOLD,AUTH 2 N.RAHMAN-HUQ,R.J.OWENS,D.I.STUART,E.Y.JONESTITL STRUCTURAL PLASTICITY OF EPH-RECEPTOR A4 FACILITATESTITL 2 CROSS-CLASS EPHRIN SIGNALLINGREF STRUCTURE V. 17 1386 2009REFN ISSN 0969-2126PMID 19836338DOI 10.1016/J.STR.2009.07.018 Variant Set Distributions Mapped Variants
General Structure Information 4bgq CDKL5 crystal structure of the human cdkl5 kinase domain 2.0Å AUTH P.CANNING,T.KROJER,S.GOUBIN,P.MAHAJAN,M.VOLLMAR,A.C.W.PIKE,AUTH 2 F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,A.BULLOCKTITL CRYSTAL STRUCTURE OF THE HUMAN CDKL5 KINASE DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3mdy BMPR1B crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1b (bmpr1b) in complex with fkbp12 and ldn- 193189 2.05Å AUTH A.CHAIKUAD,C.SANVITALE,P.MAHAJAN,N.DAGA,C.COOPER,T.KROJER,AUTH 2 I.ALFANO,S.KNAPP,F.VON DELFT,J.WEIGELT,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,C.BOUNTRA,A.BULLOCK,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE BONETITL 2 MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B (BMPR1B) IN […]
General Structure Information 1kwa CASK human cask/lin-2 pdz domain 1.93Å AUTH D.L.DANIELS,A.R.COHEN,J.M.ANDERSON,A.T.BRUNGERTITL CRYSTAL STRUCTURE OF THE HCASK PDZ DOMAIN REVEALSTITL 2 THE STRUCTURAL BASIS OF CLASS II PDZ DOMAIN TARGETTITL 3 RECOGNITIONREF NAT.STRUCT.BIOL. V. 5 317 1998REFN ISSN 1072-8368PMID 9546224DOI 10.1038/NSB0498-317 Variant Set Distributions Mapped Variants