General Structure Information 2psx KLK5 crystal structure of human kallikrein 5 in complex with leupeptin 2.3Å AUTH M.DEBELA,P.GOETTIG,V.MAGDOLEN,R.HUBER,N.M.SCHECHTER,W.BODETITL STRUCTURAL BASIS OF THE ZINC INHIBITION OF HUMAN TISSUETITL 2 KALLIKREIN 5.REF J.MOL.BIOL. V. 373 1017 2007REFN ISSN 0022-2836PMID 17881000DOI 10.1016/J.JMB.2007.08.042 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4dl3 POLH human dna polymerase eta inserting dcmpnpp opposite gg template (gg0b). 2.1Å AUTH Y.ZHAO,C.BIERTUMPFEL,M.T.GREGORY,Y.J.HUA,F.HANAOKA,W.YANGTITL STRUCTURAL BASIS FOR CHEMORESISTANCE TO CISPLATIN MEDIATEDTITL 2 BY DNA POLYMERASE ETAREF PROC.NATL.ACAD.SCI.USA V. 109 7269 2012REFN ISSN 0027-8424PMID 22529383DOI 10.1073/PNAS.1202681109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1few DIABLO crystal structure of smac/diablo 2.2Å AUTH J.CHAI,C.DU,J.W.WU,S.KYIN,X.WANG,Y.SHITITL STRUCTURAL AND BIOCHEMICAL BASIS OF APOPTOTIC ACTIVATION BYTITL 2 SMAC/DIABLO.REF NATURE V. 406 855 2000REFN ISSN 0028-0836PMID 10972280DOI 10.1038/35022514 Variant Set Distributions Mapped Variants
General Structure Information 1xb0 BIRC8 structure of the bir domain of iap-like protein 2 2.2Å AUTH H.SHIN,M.RENATUS,B.P.ECKELMAN,V.A.NUNES,AUTH 2 C.A.M.SAMPAIO,G.S.SALVESENTITL THE BIR DOMAIN OF IAP-LIKE PROTEIN 2 ISTITL 2 CONFORMATIONALLY UNSTABLE: IMPLICATIONS FORTITL 3 CASPASE INHIBITIONREF BIOCHEM.J. V. 385 1 2005REFN ISSN 0264-6021PMID 15485395DOI 10.1042/BJ20041107 Variant Set Distributions Mapped Variants
General Structure Information 1ozn RTN4R 1.5a crystal structure of the nogo receptor ligand binding domain reveals a convergent recognition scaffold mediating inhibition of myelination 1.52Å AUTH X.L.HE,J.F.BAZAN,G.MCDERMOTT,J.B.PARK,K.WANG,AUTH 2 M.TESSIER-LAVIGNE,Z.HE,K.C.GARCIATITL STRUCTURE OF THE NOGO RECEPTOR ECTODOMAIN. A RECOGNITIONTITL 2 MODULE IMPLICATED IN MYELIN INHIBITION.REF NEURON V. 38 177 2003REFN ISSN 0896-6273PMID 12718853DOI 10.1016/S0896-6273(03)00232-0 Variant Set Distributions […]
General Structure Information 4ddg OTUB1 crystal structure of human otub1/ubch5b~ub/ub 3.3Å AUTH Y.C.JUANG,M.C.LANDRY,M.SANCHES,V.VITTAL,C.C.LEUNG,AUTH 2 D.F.CECCARELLI,A.R.MATEO,J.N.PRUNEDA,D.Y.MAO,R.K.SZILARD,AUTH 3 S.ORLICKY,M.MUNRO,P.S.BRZOVIC,R.E.KLEVIT,F.SICHERI,AUTH 4 D.DUROCHERTITL OTUB1 CO-OPTS LYS48-LINKED UBIQUITIN RECOGNITION TO SUPPRESSTITL 2 E2 ENZYME FUNCTION.REF MOL.CELL V. 45 384 2012REFN ISSN 1097-2765PMID 22325355DOI 10.1016/J.MOLCEL.2012.01.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3f7g BIRC7 structure of the bir domain from ml-iap bound to a peptidomimetic 2.3Å AUTH F.COHEN,B.ALICKE,L.O.ELLIOTT,J.A.FLYGARE,T.GONCHAROV,AUTH 2 S.F.KETELTAS,M.C.FRANKLIN,S.FRANKOVITZ,J.P.STEPHAN,V.TSUI,AUTH 3 D.VUCIC,H.WONG,W.J.FAIRBROTHERTITL ORALLY BIOAVAILABLE ANTAGONISTS OF INHIBITOR OF APOPTOSISTITL 2 PROTEINS BASED ON AN AZABICYCLOOCTANE SCAFFOLDREF J.MED.CHEM. V. 52 1723 2009REFN ISSN 0022-2623PMID 19228017DOI 10.1021/JM801450C Variant Set Distributions Mapped Variants
General Structure Information 2xzg CLTC clathrin terminal domain complexed with pitstop 1 1.7Å AUTH L.VON KLEIST,W.STAHLSCHMIDT,H.BULUT,K.GROMOVA,D.PUCHKOV,AUTH 2 M.J.ROBERTSON,K.A.MACGREGOR,N.TOMLIN,A.PECHSTEIN,N.CHAU,AUTH 3 M.CHIRCOP,J.SAKOFF,J.P.VON KRIES,W.SAENGER,H.KRAUSSLICH,AUTH 4 O.SHUPLIAKOV,P.J.ROBINSON,A.MCCLUSKEY,V.HAUCKETITL ROLE OF THE CLATHRIN TERMINAL DOMAIN IN REGULATING COATEDTITL 2 PIT DYNAMICS REVEALED BY SMALL MOLECULE INHIBITION.REF CELL(CAMBRIDGE,MASS.) V. 146 471 2011REFN ISSN 0092-8674PMID 21816279DOI 10.1016/J.CELL.2011.06.025 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3caq AKR1D1 crystal structure of 5beta-reductase (akr1d1) in complex with nadph 2.2Å AUTH F.FAUCHER,L.CANTIN,V.LUU-THE,F.LABRIE,R.BRETONTITL CRYSTAL STRUCTURES OF HUMAN DELTA4-3-KETOSTEROIDTITL 2 5BETA-REDUCTASE (AKR1D1) REVEAL THE PRESENCE OF ANTITL 3 ALTERNATIVE BINDING SITE RESPONSIBLE FOR SUBSTRATETITL 4 INHIBITION (DAGGER) (,) (DOUBLE DAGGER).REF BIOCHEMISTRY V. 47 13537 2008REFN ISSN 0006-2960PMID 19075558DOI 10.1021/BI801276H Variant Set Distributions […]
General Structure Information 2wsl BCHE aged form of human butyrylcholinesterase inhibited by tabun analogue ta4 2.0Å AUTH E.CARLETTI,N.AURBEK,E.GILLON,M.LOIODICE,Y.NICOLET,AUTH 2 J.C.FONTECILLA-CAMPS,P.MASSON,H.THIERMANN,F.NACHON,F.WOREKTITL STRUCTURE-ACTIVITY ANALYSIS OF AGING AND REACTIVATION OFTITL 2 HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY ANALOGUES OFTITL 3 TABUN.REF BIOCHEM.J. V. 421 97 2009REFN ISSN 0264-6021PMID 19368529DOI 10.1042/BJ20090091 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]