Assessment of Structural Intolerance and Durability
General Structure Information 3f62 IL18 crystal structure of human il-18 in complex with ectromelia virus il- 18 binding protein 2.0Å AUTH B.KRUMM,X.MENG,Y.LI,Y.XIANG,J.DENGTITL STRUCTURAL BASIS FOR ANTAGONISM OF HUMAN INTERLEUKIN 18 BYTITL 2 POXVIRUS INTERLEUKIN 18-BINDING PROTEIN.REF PROC.NATL.ACAD.SCI.USA V. 105 20711 2008REFN ISSN 0027-8424PMID 19104048DOI 10.1073/PNAS.0809086106 Variant Set Distributions Mapped Variants
General Structure Information 3f62 IL18 crystal structure of human il-18 in complex with ectromelia virus il- 18 binding protein 2.0Å AUTH B.KRUMM,X.MENG,Y.LI,Y.XIANG,J.DENGTITL STRUCTURAL BASIS FOR ANTAGONISM OF HUMAN INTERLEUKIN 18 BYTITL 2 POXVIRUS INTERLEUKIN 18-BINDING PROTEIN.REF PROC.NATL.ACAD.SCI.USA V. 105 20711 2008REFN ISSN 0027-8424PMID 19104048DOI 10.1073/PNAS.0809086106 Variant Set Distributions Mapped Variants
General Structure Information 3f62 IL18 crystal structure of human il-18 in complex with ectromelia virus il- 18 binding protein 2.0Å AUTH B.KRUMM,X.MENG,Y.LI,Y.XIANG,J.DENGTITL STRUCTURAL BASIS FOR ANTAGONISM OF HUMAN INTERLEUKIN 18 BYTITL 2 POXVIRUS INTERLEUKIN 18-BINDING PROTEIN.REF PROC.NATL.ACAD.SCI.USA V. 105 20711 2008REFN ISSN 0027-8424PMID 19104048DOI 10.1073/PNAS.0809086106 Variant Set Distributions Mapped Variants
General Structure Information 4hcr MADCAM1 crystal structure of human madcam-1 d1d2 complexed with fab pf-547659 2.3Å AUTH T.SPRINGER,Y.YU,J.ZHU,J.-H.WANG,P.-S.HUANGTITL A DIFFERENT FOLD WITH AN INTEGRIN-BINDING LOOP SPECIALIZEDTITL 2 FOR FLEXIBILITY IN MUCOSAL ADDRESSIN CELL ADHESIONTITL 3 MOLECULE-1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2c7s PTPRK crystal structure of human protein tyrosine phosphatase kappa at 1.95a resolution 1.95Å AUTH J.ESWARAN,J.E.DEBRECZENI,E.LONGMAN,A.BARR,S.KNAPPTITL THE CRYSTAL STRUCTURE OF HUMAN RECEPTOR PROTEIN TYROSINETITL 2 KAPPA PHOSPHATASE KAPPA DOMAIN 1.REF PROTEIN SCI. V. 15 1500 2006REFN ISSN 0961-8368PMID 16672235DOI 10.1110/PS.062128706 Variant Set Distributions Mapped Variants
General Structure Information 3bpr MERTK crystal structure of catalytic domain of the proto-oncogene tyrosine- protein kinase mer in complex with inhibitor c52 2.8Å AUTH X.HUANG,P.FINERTY,J.R.WALKER,C.BUTLER-COLE,M.VEDADI,AUTH 2 M.SCHAPIRA,S.A.PARKER,B.E.TURK,D.A.THOMPSON,S.DHE-PAGANONTITL STRUCTURAL INSIGHTS INTO THE INHIBITED STATES OF THE MERTITL 2 RECEPTOR TYROSINE KINASE.REF J.STRUCT.BIOL. V. 165 88 2009REFN ISSN 1047-8477PMID 19028587DOI 10.1016/J.JSB.2008.10.003 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2om5 CNTN2 n-terminal fragment of human tax1 3.07Å AUTH M.MORTL,P.SONDEREGGER,K.DIEDERICHS,W.WELTETITL THE CRYSTAL STRUCTURE OF THE LIGAND-BINDING MODULE OF HUMANTITL 2 TAG-1 SUGGESTS A NEW MODE OF HOMOPHILIC INTERACTIONREF PROTEIN SCI. V. 16 2174 2007REFN ISSN 0961-8368PMID 17766378DOI 10.1110/PS.072802707 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3s97 CNTN1 ptprz cntn1 complex 2.3Å AUTH S.LAMPRIANOU,E.CHATZOPOULOU,J.L.THOMAS,S.BOUYAIN,S.HARROCHTITL A COMPLEX BETWEEN CONTACTIN-1 AND THE PROTEIN TYROSINETITL 2 PHOSPHATASE PTPRZ CONTROLS THE DEVELOPMENT OFTITL 3 OLIGODENDROCYTE PRECURSOR CELLS.REF PROC.NATL.ACAD.SCI.USA V. 108 17498 2011REFN ISSN 0027-8424PMID 21969550DOI 10.1073/PNAS.1108774108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ljm RUNX1 dna recognition is mediated by conformational transition and by dna bending 2.5Å AUTH D.BARTFELD,L.SHIMON,G.COUTURE,D.RABINOVICH,AUTH 2 F.FROLOW,D.LEVANON,Y.GRONER,Z.SHAKKEDTITL DNA RECOGNITION BY THE RUNX1 TRANSCRIPTION FACTORTITL 2 IS MEDIATED BY AN ALLOSTERIC TRANSITION IN THETITL 3 RUNT DOMAIN AND BY DNA BENDING.REF STRUCTURE V. 10 1395REFN ISSN 0969-2126PMID 12377125DOI 10.1016/S0969-2126(02)00853-5 Variant Set Distributions […]
General Structure Information 3f8u TAPBP tapasin/erp57 heterodimer 2.6Å AUTH G.DONG,P.A.WEARSCH,D.R.PEAPER,P.CRESSWELL,K.M.REINISCHTITL INSIGHTS INTO MHC CLASS I PEPTIDE LOADING FROM THE STRUCTURETITL 2 OF THE TAPASIN-ERP57 THIOL OXIDOREDUCTASE HETERODIMER.REF IMMUNITY V. 30 21 2009REFN ISSN 1074-7613PMID 19119025DOI 10.1016/J.IMMUNI.2008.10.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants