Assessment of Structural Intolerance and Durability
General Structure Information 1k5g RANBP1 crystal structure of ran-gdp-alfx-ranbp1-rangap complex 3.1Å AUTH M.J.SEEWALD,C.KORNER,A.WITTINGHOFER,I.R.VETTERTITL RANGAP MEDIATES GTP HYDROLYSIS WITHOUT AN ARGININETITL 2 FINGER.REF NATURE V. 415 662 2002REFN ISSN 0028-0836PMID 11832950DOI 10.1038/415662A Variant Set Distributions Mapped Variants
General Structure Information 1f5n GBP1 human guanylate binding protein-1 in complex with the gtp analogue, gmppnp. 1.7Å AUTH B.PRAKASH,L.RENAULT,G.J.PRAEFCKE,C.HERRMANN,AUTH 2 A.WITTINGHOFERTITL TRIPHOSPHATE STRUCTURE OF GUANYLATE-BINDINGTITL 2 PROTEIN 1 AND IMPLICATIONS FOR NUCLEOTIDE BINDINGTITL 3 AND GTPASE MECHANISM.REF EMBO J. V. 19 4555 2000REFN ISSN 0261-4189PMID 10970849DOI 10.1093/EMBOJ/19.17.4555 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2cbz ABCC1 structure of the human multidrug resistance protein 1 nucleotide binding domain 1 1.5Å AUTH O.RAMAEN,N.LEULLIOT,C.SIZUN,N.ULRYCK,O.PAMLARD,AUTH 2 J.-Y.LALLEMAND,H.VAN TILBEURGH,E.JACQUETTITL STRUCTURE OF THE HUMAN MULTIDRUG RESISTANCETITL 2 PROTEIN 1 NUCLEOTIDE BINDING DOMAIN 1 BOUND TOTITL 3 MG(2+)/ATP REVEALS A NON-PRODUCTIVE CATALYTICTITL 4 SITE.REF J.MOL.BIOL. V. 359 940 2006REFN ISSN 0022-2836PMID 16697012DOI 10.1016/J.JMB.2006.04.005 […]
General Structure Information 4j1y C1S the x-ray crystal structure of human complement protease c1s zymogen 2.66Å AUTH A.J.PERRY,L.C.WIJEYEWICKREMA,P.G.WILMANN,M.J.GUNZBURG,AUTH 2 L.DANDREA,J.A.IRVING,S.S.PANG,R.C.DUNCAN,J.A.WILCE,AUTH 3 J.C.WHISSTOCK,R.N.PIKETITL A MOLECULAR SWITCH GOVERNS THE INTERACTION BETWEEN THE HUMANTITL 2 COMPLEMENT PROTEASE C1S AND ITS SUBSTRATE, COMPLEMENT C4.REF J.BIOL.CHEM. V. 288 15821 2013REFN ISSN 0021-9258PMID 23592783DOI 10.1074/JBC.M113.464545 Variant Set Distributions Ripley’s K Analysis […]