Assessment of Structural Intolerance and Durability
General Structure Information 2vhf CYLD structure of the cyld usp domain 2.8Å AUTH D.KOMANDER,C.J.LORD,H.SCHEEL,S.SWIFT,K.HOFMANN,AUTH 2 A.ASHWORTH,D.BARFORDTITL THE STRUCTURE OF THE CYLD USP DOMAIN EXPLAINS ITSTITL 2 SPECIFICITY FOR LYS63-LINKED POLYUBIQUITIN ANDTITL 3 REVEALS A B-BOX MODULEREF MOL.CELL.BIOL. V. 29 451 2008REFN ISSN 0270-7306PMID 18313383DOI 10.1016/J.MOLCEL.2007.12.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2fe4 RAB6B the crystal structure of human neuronal rab6b in its inactive gdp-bound form 2.3Å AUTH I.GARCIA-SAEZ,S.TCHERNIUK,F.KOZIELSKITITL THE STRUCTURE OF HUMAN NEURONAL RAB6B IN THETITL 2 ACTIVE AND INACTIVE FORM.REF ACTA CRYSTALLOGR.,SECT.D V. 62 725 2006REFN ISSN 0907-4449PMID 16790928DOI 10.1107/S0907444906015319 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2z0b GPCPD1 crystal structure of cbm20 domain of human putative glycerophosphodiester phosphodiesterase 5 (kiaa1434) 2.0Å AUTH S.SAIJO,A.NISHINO,S.KISHISHITA,M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF CBM20 DOMAIN OF HUMAN PUTATIVETITL 2 GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 5 (KIAA1434)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4h3k SSU72 crystal structure of a ternary complex of human symplekin ntd, human ssu72 and a rna polymerase ii ctd peptide phosphorylated at ser-2, ser-5 and ser-7 2.0Å AUTH K.XIANG,J.L.MANLEY,L.TONGTITL AN UNEXPECTED BINDING MODE FOR A POL II CTD PEPTIDETITL 2 PHOSPHORYLATED AT SER7 IN THE ACTIVE SITE OF THE CTDTITL 3 […]
General Structure Information 2fp0 ADPRHL2 human adp-ribosylhydrolase 3 2.05Å AUTH C.MUELLER-DIECKMANN,S.KERNSTOCK,M.LISUREK,J.P.VON KRIES,AUTH 2 F.HAAG,M.S.WEISS,F.KOCH-NOLTETITL THE STRUCTURE OF HUMAN ADP-RIBOSYLHYDROLASE 3 (ARH3)TITL 2 PROVIDES INSIGHTS INTO THE REVERSIBILITY OF PROTEINTITL 3 ADP-RIBOSYLATION.REF PROC.NATL.ACAD.SCI.USA V. 103 15026 2006REFN ISSN 0027-8424PMID 17015823DOI 10.1073/PNAS.0606762103 Variant Set Distributions Mapped Variants
General Structure Information 2ai6 PHPT1 solution structure of human phosphohistidine phosphatase 1 -1.0Å AUTH W.GONG,Y.LI,G.CUI,J.HU,H.FANG,C.JIN,B.XIATITL SOLUTION STRUCTURE AND CATALYTIC MECHANISM OFTITL 2 HUMAN PROTEIN HISTIDINE PHOSPHATASE 1.REF BIOCHEM.J. V. 418 337 2009REFN ISSN 0264-6021PMID 18991813DOI 10.1042/BJ20081571 Variant Set Distributions Mapped Variants
General Structure Information 2khx DROSHA drosha double-stranded rna binding motif -1.0Å AUTH G.A.MUELLER,M.T.MILLER,E.F.DEROSE,M.GHOSH,R.E.LONDON,AUTH 2 T.M.HALLTITL SOLUTION STRUCTURE OF THE DROSHA DOUBLE-STRANDED RNA-BINDINGTITL 2 DOMAIN.REF SILENCE V. 1 2 2010REFN ESSN 1758-907XPMID 20226070DOI 10.1186/1758-907X-1-2 Variant Set Distributions Mapped Variants
General Structure Information 1mu9 TDP1 crystal structure of a human tyrosyl-dna phosphodiesterase (tdp1)- vanadate complex 2.05Å AUTH D.R.DAVIES,H.INTERTHAL,J.J.CHAMPOUX,W.G.J.HOLTITL INSIGHTS INTO SUBSTRATE BINDING AND CATALYTIC MECHANISM OFTITL 2 HUMAN TYROSYL-DNA PHOSPHODIESTERASE (TDP1) FROM VANADATE-TITL 3 AND TUNGSTATE-INHIBITED STRUCTURESREF J.MOL.BIOL. V. 324 917 2002REFN ISSN 0022-2836PMID 12470949DOI 10.1016/S0022-2836(02)01154-3 Variant Set Distributions Mapped Variants
General Structure Information 4dpz HRASLS2 crystal structure of human hrasls2 1.25Å AUTH M.GOLCZAK,P.D.KISER,A.E.SEARS,D.T.LODOWSKI,W.S.BLANER,AUTH 2 K.PALCZEWSKITITL STRUCTURAL BASIS FOR THE ACYLTRANSFERASE ACTIVITY OFTITL 2 LECITHIN:RETINOL ACYLTRANSFERASE-LIKE PROTEINS.REF J.BIOL.CHEM. V. 287 23790 2012REFN ISSN 0021-9258PMID 22605381DOI 10.1074/JBC.M112.361550 Variant Set Distributions Mapped Variants
General Structure Information 3fk2 ARHGAP35 crystal structure of the rhogap domain of human glucocorticoid receptor dna-binding factor 1 2.8Å AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,P.LOPPNAU,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RHOGAP DOMAIN OF HUMANTITL 2 GLUCOCORTICOID RECEPTOR DNA-BINDING FACTOR 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants