Assessment of Structural Intolerance and Durability
General Structure Information 2hzp KYNU crystal structure of homo sapiens kynureninase 2.0Å AUTH S.LIMA,R.KHRISTOFOROV,C.MOMANY,R.S.PHILLIPSTITL CRYSTAL STRUCTURE OF HOMO SAPIENS KYNURENINASE.REF BIOCHEMISTRY V. 46 2735 2007REFN ISSN 0006-2960PMID 17300176DOI 10.1021/BI0616697 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2y1h TATDN3 crystal structure of the human tatd-domain protein 3 (tatdn3) 2.5Å AUTH J.R.C.MUNIZ,S.PURANIK,T.KROJER,W.W.YUE,E.UGOCHUKWU,AUTH 2 P.FILIPPAKOPOULOS,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 J.WEIGELT,C.BOUNTRA,K.L.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE HUMAN TATD-DOMAIN PROTEIN 3TITL 2 (TATDN3)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2i7a CAPN13 domain iv of human calpain 13 1.8Å AUTH J.R.WALKER,K.NG,T.L.DAVIS,R.RAVULAPALLI,C.BUTLER-COLE,AUTH 2 P.J.FINERTY JR.,E.M.NEWMAN,J.WEIGELT,M.SUNDSTROM,AUTH 3 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL STRUCTURE OF HUMAN CALPAIN 13REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2nt2 SSH2 crystal structure of slingshot phosphatase 2 2.1Å AUTH S.K.JUNG,D.G.JEONG,T.S.YOON,J.H.KIM,S.E.RYU,S.J.KIMTITL CRYSTAL STRUCTURE OF HUMAN SLINGSHOT PHOSPHATASE 2.REF PROTEINS V. 68 408 2007REFN ISSN 0887-3585PMID 17427953DOI 10.1002/PROT.21399 Variant Set Distributions Mapped Variants
General Structure Information 2g59 PTPRO crystal structure of the catalytic domain of protein tyrosine phosphatase from homo sapiens 2.19Å AUTH S.C.ALMO,J.B.BONANNO,J.M.SAUDER,S.EMTAGE,AUTH 2 T.P.DILORENZO,V.MALASHKEVICH,S.R.WASSERMAN,AUTH 3 S.SWAMINATHAN,S.ESWARAMOORTHY,R.AGARWAL,D.KUMARAN,AUTH 4 M.MADEGOWDA,S.RAGUMANI,Y.PATSKOVSKY,J.ALVARADO,AUTH 5 U.A.RAMAGOPAL,J.FABER-BARATA,M.R.CHANCE,A.SALI,AUTH 6 A.FISER,Z.Y.ZHANG,D.S.LAWRENCE,S.K.BURLEYTITL STRUCTURAL GENOMICS OF PROTEIN PHOSPHATASES.REF J.STRUCT.FUNCT.GENOM. V. 8 121 2007REFN ISSN 1345-711XPMID 18058037DOI 10.1007/S10969-007-9036-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2dwp PFKFB3 a pseudo substrate complex of 6-phosphofructo-2-kinase of pfkfb 2.7Å AUTH S.G.KIM,M.CAVALIER,M.R.EL-MAGHRABI,Y.H.LEETITL A DIRECT SUBSTRATE-SUBSTRATE INTERACTION FOUND INTITL 2 THE KINASE DOMAIN OF THE BIFUNCTIONAL ENZYME,TITL 3 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-TITL 4 BISPHOSPHATASEREF J.MOL.BIOL. V. 370 14 2007REFN ISSN 0022-2836PMID 17499765DOI 10.1016/J.JMB.2007.03.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ebq DESI1 crystal structure of human pppde1 1.9Å AUTH J.R.WALKER,M.AKUTSU,L.QIU,Y.LI,Y.SLESSAREV,AUTH 2 J.WEIGELT,C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANONTITL STRUCTURE OF HUMAN PPPDE1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4bou OTUD3 structure of otud3 otu domain 1.55Å AUTH T.E.T.MEVISSEN,M.K.HOSPENTHAL,P.P.GEURINK,P.R.ELLIOTT,AUTH 2 M.AKUTSU,N.ARNAUDO,R.EKKEBUS,Y.KULATHU,T.WAUER,F.EL OUALID,AUTH 3 S.M.V.FREUND,H.OVAA,D.KOMANDERTITL OTU DEUBIQUITINASES REVEAL MECHANISMS OF LINKAGETITL 2 SPECIFICITY AND ENABLE UBIQUITIN CHAIN RESTRICTIONTITL 3 ANALYSIS.REF CELL(CAMBRIDGE,MASS.) V. 154 169 2013REFN ISSN 0092-8674PMID 23827681DOI 10.1016/J.CELL.2013.05.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2y96 DUPD1 structure of human dual-specificity phosphatase 27 2.38Å AUTH G.T.LOUNTOS,J.E.TROPEA,D.S.WAUGHTITL STRUCTURE OF HUMAN DUAL-SPECIFICITY PHOSPHATASETITL 2 AT 2.38A RESOLUTIONREF ACTA CRYSTALLOGR.,SECT.D V. 67 471 2011REFN ISSN 0907-4449PMID 21543850DOI 10.1107/S090744491100970X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1fpz CDKN3 crystal structure analysis of kinase associated phosphatase (kap) with a substitution of the catalytic site cysteine (cys140) to a serine 2.0Å AUTH H.SONG,N.HANLON,N.R.BROWN,M.E.NOBLE,L.N.JOHNSON,AUTH 2 D.BARFORDTITL PHOSPHOPROTEIN-PROTEIN INTERACTIONS REVEALED BYTITL 2 THE CRYSTAL STRUCTURE OF KINASE-ASSOCIATEDTITL 3 PHOSPHATASE IN COMPLEX WITH PHOSPHOCDK2.REF MOL.CELL V. 7 615 2001REFN ISSN 1097-2765PMID 11463386DOI 10.1016/S1097-2765(01)00208-8 […]