General Structure Information 2vjf MDM2 crystal structure of the mdm2-mdmx ring domain heterodimer 2.3Å AUTH K.LINKE,P.D.MACE,C.A.SMITH,D.L.VAUX,J.SILKE,C.L.DAYTITL STRUCTURE OF THE MDM2/MDMX RING DOMAIN HETERODIMERTITL 2 REVEALS DIMERIZATION IS REQUIRED FOR THEIRTITL 3 UBIQUITYLATION IN TRANS.REF CELL DEATH DIFFER. V. 15 841 2008REFN ISSN 1350-9047PMID 18219319DOI 10.1038/SJ.CDD.4402309 Variant Set Distributions Mapped Variants
General Structure Information 2ka4 STAT2 nmr structure of the cbp-taz1/stat2-tad complex -1.0Å AUTH J.M.WOJCIAK,M.A.MARTINEZ-YAMOUT,H.J.DYSON,AUTH 2 P.E.WRIGHTTITL STRUCTURAL BASIS FOR RECRUITMENT OF CBP/P300TITL 2 COACTIVATORS BY STAT1 AND STAT2 TRANSACTIVATIONTITL 3 DOMAINSREF EMBO J. V. 28 948 2009REFN ISSN 0261-4189PMID 19214187DOI 10.1038/EMBOJ.2009.30 Variant Set Distributions Mapped Variants
General Structure Information 3fey KPNA2 crystal structure of the cbc-importin alpha complex. 2.2Å AUTH S.M.DIAS,K.F.WILSON,K.S.ROJAS,A.L.AMBROSIO,R.A.CERIONETITL THE MOLECULAR BASIS FOR THE REGULATION OF THE CAP-BINDINGTITL 2 COMPLEX BY THE IMPORTINS.REF NAT.STRUCT.MOL.BIOL. V. 16 930 2009REFN ISSN 1545-9993PMID 19668212DOI 10.1038/NSMB.1649 Variant Set Distributions Mapped Variants
General Structure Information 2rd0 PIK3CA structure of a human p110alpha/p85alpha complex 3.05Å AUTH C.H.HUANG,D.MANDELKER,O.SCHMIDT-KITTLER,Y.SAMUELS,AUTH 2 V.E.VELCULESCU,K.W.KINZLER,B.VOGELSTEIN,S.B.GABELLI,AUTH 3 L.M.AMZELTITL THE STRUCTURE OF A HUMAN P110ALPHA/P85ALPHA COMPLEXTITL 2 ELUCIDATES THE EFFECTS OF ONCOGENIC PI3KALPHA MUTATIONS.REF SCIENCE V. 318 1744 2007REFN ISSN 0036-8075PMID 18079394DOI 10.1126/SCIENCE.1150799 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3d42 PTPN7 crystal structure of heptp in complex with a monophosphorylated erk2 peptide 2.46Å AUTH D.A.CRITTON,A.TORTAJADA,G.STETSON,W.PETI,R.PAGETITL STRUCTURAL BASIS OF SUBSTRATE RECOGNITION BY HEMATOPOIETICTITL 2 TYROSINE PHOSPHATASE.REF BIOCHEMISTRY V. 47 13336 2008REFN ISSN 0006-2960PMID 19053285DOI 10.1021/BI801724N Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kvq KDR crystal structure of vegfr2 extracellular domain d7 2.7Å AUTH Y.YANG,P.XIE,Y.OPATOWSKY,J.SCHLESSINGERTITL DIRECT CONTACTS BETWEEN EXTRACELLULARTITL 2 MEMBRANE-PROXIMAL DOMAINS ARE REQUIRED FOR VEGFTITL 3 RECEPTOR ACTIVATION AND CELL SIGNALINGREF PROC.NATL.ACAD.SCI.USA V. 107 1906 2010REFN ISSN 0027-8424PMID 20080685DOI 10.1073/PNAS.0914052107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3dzy PPARG intact ppar gamma – rxr alpha nuclear receptor complex on dna bound with rosiglitazone, 9-cis retinoic acid and ncoa2 peptide 3.1Å AUTH V.CHANDRA,P.HUANG,Y.HAMURO,S.RAGHURAM,Y.WANG,T.P.BURRIS,AUTH 2 F.RASTINEJADTITL STRUCTURE OF THE INTACT PPAR-GAMMA-RXR- NUCLEAR RECEPTORTITL 2 COMPLEX ON DNA.REF NATURE V. 456 350 2008REFN ISSN 0028-0836PMID 19043829DOI 10.1038/NATURE07413 Variant Set Distributions Ripley’s K […]