Assessment of Structural Intolerance and Durability
General Structure Information 2x2u RET first two cadherin-like domains from human ret 2.0Å AUTH S.KJAER,S.HANRAHAN,N.TOTTY,N.Q.MCDONALDTITL MAMMAL-RESTRICTED ELEMENTS PREDISPOSE HUMAN RET TOTITL 2 FOLDING IMPAIRMENT BY HSCR MUTATIONS.REF NAT.STRUCT.MOL.BIOL. V. 17 726 2010REFN ISSN 1545-9993PMID 20473317DOI 10.1038/NSMB.1808 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2x2m RET crystal structure of phosphorylated ret tyrosine kinase domain with inhibitor 2.5Å AUTH L.MOLOGNI,R.ROSTAGNO,S.BRUSSOLO,P.P.KNOWLES,AUTH 2 S.KJAER,J.MURRAY-RUST,E.ROSSO,A.ZAMBON,L.SCAPOZZA,AUTH 3 N.Q.MCDONALD,V.LUCCHINI,C.GAMBACORTI-PASSERINITITL SYNTHESIS, STRUCTURE-ACTIVITY RELATIONSHIP ANDTITL 2 CRYSTALLOGRAPHIC STUDIES OF 3-SUBSTITUTED INDOLIN-TITL 3 2-ONE RET INHIBITORS.REF BIOORG.MED.CHEM. V. 18 1482 2010REFN ISSN 0968-0896PMID 20117004DOI 10.1016/J.BMC.2010.01.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]