Assessment of Structural Intolerance and Durability
General Structure Information 1vtn FOXA3 co-crystal structure of the hnf-3/fork head dna-recognition motif resembles histone h5 2.5Å AUTH K.L.CLARK,E.D.HALAY,E.LAI,S.K.BURLEYTITL CO-CRYSTAL STRUCTURE OF THE HNF-3/FORK HEAD DNA-RECOGNITIONTITL 2 MOTIF RESEMBLES HISTONE H5REF NATURE V. 364 412 1993REFN ISSN 0028-0836PMID 8332212DOI 10.1038/364412A0 Variant Set Distributions Mapped Variants
General Structure Information 4iyp IGBP1 structure of the npp2ac-alpha4 complex 2.8Å AUTH L.JIANG,V.STANEVICH,K.A.SATYSHUR,M.KONG,G.R.WATKINS,AUTH 2 B.E.WADZINSKI,R.SENGUPTA,Y.XINGTITL STRUCTURAL BASIS OF PROTEIN PHOSPHATASE 2A STABLE LATENCY.REF NAT COMMUN V. 4 1699 2013REFN ESSN 2041-1723PMID 23591866DOI 10.1038/NCOMMS2663 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1e17 FOXO4 solution structure of the dna binding domain of the human forkhead transcription factor afx (foxo4) -1.0Å AUTH J.WEIGELT,I.CLIMENT,K.DAHLMAN-WRIGHT,M.WIKSTROMTITL 1H, 13C AND 15N RESONANCE ASSIGNMENTS OF THE DNATITL 2 BINDING DOMAIN OF THE HUMAN FORKHEAD TRANSCRIPTIONTITL 3 FACTOR AFXREF J.BIOMOL.NMR V. 17 181 2000REFN ISSN 0925-2738PMID 10921784DOI 10.1023/A:1008358816478 Variant Set Distributions […]
General Structure Information 2o94 HDAC4 the 97h/f mutant structure of a glutamine-rich domain from histone deacetylase 4 3.0Å AUTH L.GUO,A.HAN,D.L.BATES,J.CAO,L.CHENTITL CRYSTAL STRUCTURE OF A CONSERVED N-TERMINAL DOMAINTITL 2 OF HISTONE DEACETYLASE 4 REVEALS FUNCTIONALTITL 3 INSIGHTS INTO GLUTAMINE-RICH DOMAINS.REF PROC.NATL.ACAD.SCI.USA V. 104 4297 2007REFN ISSN 0027-8424PMID 17360518DOI 10.1073/PNAS.0608041104 Variant Set Distributions Mapped Variants
General Structure Information 3jts B2M gy9-mamu-a*02-hb2m 2.8Å AUTH L.DAITITL STRUCTURE OF MAMU A*2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2qkh GIPR crystal structure of the extracellular domain of human gip receptor in complex with the hormone gip 1.9Å AUTH C.PARTHIER,M.KLEINSCHMIDT,P.NEUMANN,R.RUDOLPH,AUTH 2 S.MANHART,D.SCHLENZIG,J.FANGHANEL,J.-U.RAHFELD,AUTH 3 H.-U.DEMUTH,M.T.STUBBSTITL CRYSTAL STRUCTURE OF THE INCRETIN-BOUNDTITL 2 EXTRACELLULAR DOMAIN OF A G PROTEIN-COUPLEDTITL 3 RECEPTORREF PROC.NATL.ACAD.SCI.USA V. 104 13942 2007REFN ISSN 0027-8424PMID 17715056DOI 10.1073/PNAS.0706404104 Variant Set Distributions Ripley’s […]
General Structure Information 1s31 TUB crystal structure analysis of the human tub protein (isoform a) spanning residues 289 through 561 2.7Å AUTH S.BOUTBOUL,K.J.CARROLL,A.BASDEVANT,C.GOMEZ,E.NANDROT,AUTH 2 K.CLEMENT,L.SHAPIRO,M.ABITBOLTITL A NOVEL HUMAN OBESITY AND SENSORY DEFICIT SYNDROME RESULTINGTITL 2 FROM A MUTATION IN THE TUB GENEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3sog AMPH crystal structure of the bar domain of human amphiphysin, isoform 1 2.3Å Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3l82 TERF1 x-ray crystal structure of trf1 and fbx4 complex 2.4Å AUTH Z.ZENG,W.WANG,Y.YANG,Y.CHEN,X.YANG,J.A.DIEHL,X.LIU,M.LEITITL STRUCTURAL BASIS OF SELECTIVE UBIQUITINATION OF TRF1 BYTITL 2 SCF(FBX4)REF DEV.CELL V. 18 214 2010REFN ISSN 1534-5807PMID 20159592DOI 10.1016/J.DEVCEL.2010.01.007 Variant Set Distributions Mapped Variants
General Structure Information 3alo MAP2K4 crystal structure of human non-phosphorylated mkk4 kinase domain ternary complex with amp-pnp and p38 peptide 2.6Å AUTH T.MATSUMOTO,T.KINOSHITA,Y.KIRII,K.YOKOTA,K.HAMADA,T.TADATITL CRYSTAL STRUCTURES OF MKK4 KINASE DOMAIN REVEAL THATTITL 2 SUBSTRATE PEPTIDE BINDS TO AN ALLOSTERIC SITE AND INDUCES ANTITL 3 AUTO-INHIBITION STATEREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 400 369 2010REFN ISSN 0006-291XPMID 20732303DOI 10.1016/J.BBRC.2010.08.071 Variant […]