Assessment of Structural Intolerance and Durability
General Structure Information 3coa FOXO1 crystal structure of foxo1 dbd bound to ire dna 2.2Å AUTH M.M.BRENT,R.ANAND,R.MARMORSTEINTITL STRUCTURAL BASIS FOR DNA RECOGNITION BY FOXO1 ANDTITL 2 ITS REGULATION BY POSTTRANSLATIONAL MODIFICATION.REF STRUCTURE V. 16 1407 2008REFN ISSN 0969-2126PMID 18786403DOI 10.1016/J.STR.2008.06.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2c6y FOXK2 crystal structure of interleukin enhancer-binding factor 1 bound to dna 2.4Å AUTH K.-L.TSAI,C.-Y.HUANG,C.-H.CHANG,Y.-J.SUN,AUTH 2 W.-J.CHUANG,C.-D.HSIAOTITL CRYSTAL STRUCTURE OF THE HUMAN FOXK1A-DNA COMPLEXTITL 2 AND ITS IMPLICATIONS ON THE DIVERSE BINDINGTITL 3 SPECIFICITY OF WINGED HELIX/FORKHEAD PROTEINS.REF J.BIOL.CHEM. V. 281 17400 2006REFN ISSN 0021-9258PMID 16624804DOI 10.1074/JBC.M600478200 Variant Set Distributions Mapped Variants
General Structure Information 3gut RELA crystal structure of a higher-order complex of p50:rela bound to the hiv-1 ltr 3.59Å AUTH J.C.STROUD,A.OLTMAN,A.HAN,D.L.BATES,L.CHENTITL STRUCTURAL BASIS OF HIV-1 ACTIVATION BYTITL 2 NF-KAPPAB–A HIGHER-ORDER COMPLEX OF P50:RELA BOUNDTITL 3 TO THE HIV-1 LTR.REF J.MOL.BIOL. V. 393 98 2009REFN ISSN 0022-2836PMID 19683540DOI 10.1016/J.JMB.2009.08.023 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1vtn FOXA3 co-crystal structure of the hnf-3/fork head dna-recognition motif resembles histone h5 2.5Å AUTH K.L.CLARK,E.D.HALAY,E.LAI,S.K.BURLEYTITL CO-CRYSTAL STRUCTURE OF THE HNF-3/FORK HEAD DNA-RECOGNITIONTITL 2 MOTIF RESEMBLES HISTONE H5REF NATURE V. 364 412 1993REFN ISSN 0028-0836PMID 8332212DOI 10.1038/364412A0 Variant Set Distributions Mapped Variants
General Structure Information 4iyp IGBP1 structure of the npp2ac-alpha4 complex 2.8Å AUTH L.JIANG,V.STANEVICH,K.A.SATYSHUR,M.KONG,G.R.WATKINS,AUTH 2 B.E.WADZINSKI,R.SENGUPTA,Y.XINGTITL STRUCTURAL BASIS OF PROTEIN PHOSPHATASE 2A STABLE LATENCY.REF NAT COMMUN V. 4 1699 2013REFN ESSN 2041-1723PMID 23591866DOI 10.1038/NCOMMS2663 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1e17 FOXO4 solution structure of the dna binding domain of the human forkhead transcription factor afx (foxo4) -1.0Å AUTH J.WEIGELT,I.CLIMENT,K.DAHLMAN-WRIGHT,M.WIKSTROMTITL 1H, 13C AND 15N RESONANCE ASSIGNMENTS OF THE DNATITL 2 BINDING DOMAIN OF THE HUMAN FORKHEAD TRANSCRIPTIONTITL 3 FACTOR AFXREF J.BIOMOL.NMR V. 17 181 2000REFN ISSN 0925-2738PMID 10921784DOI 10.1023/A:1008358816478 Variant Set Distributions […]
General Structure Information 3g73 FOXM1 structure of the foxm1 dna binding 2.21Å AUTH D.R.LITTLER,M.ALVAREZ-FERNANDEZ,A.STEIN,R.G.HIBBERT,AUTH 2 T.HEIDEBRECHT,P.ALOY,R.H.MEDEMA,A.PERRAKISTITL STRUCTURE OF THE FOXM1 DNA-RECOGNITION DOMAIN BOUND TO ATITL 2 PROMOTER SEQUENCEREF NUCLEIC ACIDS RES. 2010REFN ESSN 1362-4962PMID 20360045DOI 10.1093/NAR/GKQ194 Variant Set Distributions Mapped Variants
General Structure Information 3coa FOXO1 crystal structure of foxo1 dbd bound to ire dna 2.2Å AUTH M.M.BRENT,R.ANAND,R.MARMORSTEINTITL STRUCTURAL BASIS FOR DNA RECOGNITION BY FOXO1 ANDTITL 2 ITS REGULATION BY POSTTRANSLATIONAL MODIFICATION.REF STRUCTURE V. 16 1407 2008REFN ISSN 0969-2126PMID 18786403DOI 10.1016/J.STR.2008.06.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2c6y FOXK2 crystal structure of interleukin enhancer-binding factor 1 bound to dna 2.4Å AUTH K.-L.TSAI,C.-Y.HUANG,C.-H.CHANG,Y.-J.SUN,AUTH 2 W.-J.CHUANG,C.-D.HSIAOTITL CRYSTAL STRUCTURE OF THE HUMAN FOXK1A-DNA COMPLEXTITL 2 AND ITS IMPLICATIONS ON THE DIVERSE BINDINGTITL 3 SPECIFICITY OF WINGED HELIX/FORKHEAD PROTEINS.REF J.BIOL.CHEM. V. 281 17400 2006REFN ISSN 0021-9258PMID 16624804DOI 10.1074/JBC.M600478200 Variant Set Distributions Mapped Variants
General Structure Information 3gut RELA crystal structure of a higher-order complex of p50:rela bound to the hiv-1 ltr 3.59Å AUTH J.C.STROUD,A.OLTMAN,A.HAN,D.L.BATES,L.CHENTITL STRUCTURAL BASIS OF HIV-1 ACTIVATION BYTITL 2 NF-KAPPAB–A HIGHER-ORDER COMPLEX OF P50:RELA BOUNDTITL 3 TO THE HIV-1 LTR.REF J.MOL.BIOL. V. 393 98 2009REFN ISSN 0022-2836PMID 19683540DOI 10.1016/J.JMB.2009.08.023 Variant Set Distributions Ripley’s K Analysis Plots […]