Assessment of Structural Intolerance and Durability
General Structure Information 1g2t CCL26 solution structure of eotaxin-3 -1.0Å AUTH J.YE,K.L.MAYER,M.R.MAYER,M.J.STONETITL NMR SOLUTION STRUCTURE AND BACKBONE DYNAMICS OFTITL 2 THE CC CHEMOKINE EOTAXIN-3.REF BIOCHEMISTRY V. 40 7820 2001REFN ISSN 0006-2960PMID 11425309DOI 10.1021/BI010252S Variant Set Distributions Mapped Variants
General Structure Information 4nh3 DICER1 structure of human dicer platform-paz-connector helix cassette in complex with 13-mer sirna having 5-pu and uu-3 ends (2.6 angstrom resolution) 2.62Å AUTH Y.TIAN,D.K.SIMANSHU,J.B.MA,J.E.PARK,I.HEO,V.N.KIM,D.J.PATELTITL A PHOSPHATE-BINDING POCKET WITHIN THE PLATFORM-PAZ-CONNECTORTITL 2 HELIX CASSETTE OF HUMAN DICER.REF MOL.CELL V. 53 606 2014REFN ISSN 1097-2765PMID 24486018DOI 10.1016/J.MOLCEL.2014.01.003 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2ch0 LEMD3 solution structure of the human man1 c-terminal domain (residues 655-775) -1.0Å AUTH S.CAPUTO,J.COUPRIE,I.DUBAND-GOULET,F.LIN,S.BRAUD,AUTH 2 M.GONDRY,H.J.WORMAN,B.GILQUIN,S.ZINN-JUSTINTITL THE CARBOXYL-TERMINAL NUCLEOPLASMIC REGION OF MAN1TITL 2 EXHIBITS A DNA BINDING WINGED HELIX DOMAIN.REF J.BIOL.CHEM. V. 281 18208 2006REFN ISSN 0021-9258PMID 16648637DOI 10.1074/JBC.M601980200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2pso STARD13 human stard13 (dlc2) lipid transfer and protein localization domain 2.8Å AUTH A.G.THORSELL,W.H.LEE,C.PERSSON,M.I.SIPONEN,M.NILSSON,AUTH 2 R.D.BUSAM,T.KOTENYOVA,H.SCHULER,L.LEHTIOTITL COMPARATIVE STRUCTURAL ANALYSIS OF LIPID BINDING STARTTITL 2 DOMAINS.REF PLOS ONE V. 6 19521 2011REFN ESSN 1932-6203PMID 21738568DOI 10.1371/JOURNAL.PONE.0019521 Variant Set Distributions Mapped Variants
General Structure Information 1jo6 KCNMB2 solution structure of the cytoplasmic n-terminus of the bk beta-subunit kcnmb2 -1.0Å AUTH D.BENTROP,M.BEYERMANN,R.WISSMANN,B.FAKLERTITL NMR STRUCTURE OF THE BALL-AND-CHAIN DOMAIN OFTITL 2 KCNMB2, THE BETA 2-SUBUNIT OF LARGE CONDUCTANCETITL 3 CA2+- AND VOLTAGE-ACTIVATED POTASSIUM CHANNELS.REF J.BIOL.CHEM. V. 276 42116 2001REFN ISSN 0021-9258PMID 11517232DOI 10.1074/JBC.M107118200 Variant Set Distributions Mapped Variants
General Structure Information 3rsn ASH2L crystal structure of the n-terminal region of human ash2l 2.1Å AUTH Y.CHEN,B.WAN,K.C.WANG,F.CAO,Y.YANG,A.PROTACIO,Y.DOU,AUTH 2 H.Y.CHANG,M.LEITITL CRYSTAL STRUCTURE OF THE N-TERMINAL REGION OF HUMAN ASH2LTITL 2 SHOWS A WINGED-HELIX MOTIF INVOLVED IN DNA BINDING.REF EMBO REP. V. 12 797 2011REFN ISSN 1469-221XPMID 21660059DOI 10.1038/EMBOR.2011.101 Variant Set Distributions Mapped Variants
General Structure Information 2d9d BAG5 solution structure of the bag domain (275-350) of bag-family molecular chaperone regulator-5 -1.0Å AUTH A.ARAKAWA,N.HANDA,N.OHSAWA,M.SHIDA,T.KIGAWA,AUTH 2 F.HAYASHI,M.SHIROUZU,S.YOKOYAMATITL THE C-TERMINAL BAG DOMAIN OF BAG5 INDUCESTITL 2 CONFORMATIONAL CHANGES OF THE HSP70TITL 3 NUCLEOTIDE-BINDING DOMAIN FOR ADP-ATP EXCHANGEREF STRUCTURE V. 18 309 2010REFN ISSN 0969-2126PMID 20223214DOI 10.1016/J.STR.2010.01.004 Variant Set Distributions Mapped Variants
General Structure Information 2l2o ABRACL solution structure of human hspc280 protein -1.0Å AUTH J.LIN,T.ZHOU,J.WANGTITL SOLUTION STRUCTURE OF THE HUMAN HSPC280 PROTEINREF PROTEIN SCI. V. 20 216 2011REFN ISSN 0961-8368PMID 21082705DOI 10.1002/PRO.548 Variant Set Distributions Mapped Variants
General Structure Information 1mhq GGA2 crystal structure of human gga2 vhs domain 2.2Å AUTH G.ZHU,X.HE,S.TERZYAN,P.ZHAI,J.TANG,X.C.ZHANGTITL CRYSTAL STRUCTURE OF GGA2 VHS DOMAIN AND ITSTITL 2 IMPLICATION IN PLASTICITY IN THE LIGAND BINDINGTITL 3 POCKETREF FEBS LETT. V. 537 171 2003REFN ISSN 0014-5793PMID 12606052DOI 10.1016/S0014-5793(03)00095-4 Variant Set Distributions Mapped Variants
General Structure Information 1j0w DOK5 crystal structure analysis of the dok-5 ptb domain 2.5Å AUTH N.SHI,Y.DING,B.Q.QIANG,J.G.YUAN,Z.H.RAOTITL CRYSTAL STRUCTURE ANALYSIS OF THE DOK-5 PTB DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants