Assessment of Structural Intolerance and Durability
General Structure Information 2c5d AXL structure of a minimal gas6-axl complex 3.3Å AUTH T.SASAKI,P.G.KNYAZEV,N.J.CLOUT,Y.CHEBURKIN,AUTH 2 W.GOEHRING,A.ULLRICH,R.TIMPL,E.HOHENESTERTITL STRUCTURAL BASIS FOR GAS6-AXL SIGNALLING.REF EMBO J. V. 25 80 2006REFN ISSN 0261-4189PMID 16362042DOI 10.1038/SJ.EMBOJ.7600912 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kfd TGFBR1 ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily 3.0Å AUTH S.RADAEV,Z.ZOU,T.HUANG,E.M.LAFER,A.P.HINCK,P.D.SUNTITL TERNARY COMPLEX OF TRANSFORMING GROWTH FACTOR-BETA1 REVEALSTITL 2 ISOFORM-SPECIFIC LIGAND RECOGNITION AND RECEPTORTITL 3 RECRUITMENT IN THE SUPERFAMILY.REF J.BIOL.CHEM. V. 285 14806 2010REFN ISSN 0021-9258PMID 20207738DOI 10.1074/JBC.M109.079921 Variant Set Distributions Mapped Variants
General Structure Information 2v5e GDNF the structure of the gdnf:coreceptor complex: insights into ret signalling and heparin binding. 2.35Å AUTH V.PARKASH,V.-M.LEPPANEN,H.VIRTANEN,J.-M.JURVANSUU,AUTH 2 M.M.BESPALOV,Y.A.SIDOROVA,P.RUNEBERG-ROOS,M.SAARMA,AUTH 3 A.GOLDMANTITL THE STRUCTURE OF THE GLIAL CELL LINE-DERIVEDTITL 2 NEUROTROPHIC FACTOR-CORECEPTOR COMPLEX: INSIGHTSTITL 3 INTO RET SIGNALING AND HEPARIN BINDING.REF J.BIOL.CHEM. V. 283 35164 2008REFN ISSN 0021-9258PMID 18845535DOI 10.1074/JBC.M802543200 Variant Set […]
General Structure Information 1cnt CNTF ciliary neurotrophic factor 2.4Å AUTH N.Q.MCDONALD,N.PANAYOTATOS,W.A.HENDRICKSONTITL CRYSTAL STRUCTURE OF DIMERIC HUMAN CILIARYTITL 2 NEUROTROPHIC FACTOR DETERMINED BY MAD PHASING.REF EMBO J. V. 14 2689 1995REFN ISSN 0261-4189PMID 7796798 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1nt3 NTF3 human neurotrophin-3 2.4Å AUTH M.J.BUTTE,P.K.HWANG,W.C.MOBLEY,R.J.FLETTERICKTITL CRYSTAL STRUCTURE OF NEUROTROPHIN-3 HOMODIMER SHOWS DISTINCTTITL 2 REGIONS ARE USED TO BIND ITS RECEPTORS.REF BIOCHEMISTRY V. 37 16846 1998REFN ISSN 0006-2960PMID 9836577DOI 10.1021/BI981254O Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1iil FGFR2 crystal structure of pro253arg apert mutant fgf receptor 2 (fgfr2) in complex with fgf2 2.3Å AUTH O.A.IBRAHIMI,A.V.ELISEENKOVA,A.N.PLOTNIKOV,K.YU,AUTH 2 D.M.ORNITZ,M.MOHAMMADITITL STRUCTURAL BASIS FOR FIBROBLAST GROWTH FACTORTITL 2 RECEPTOR 2 ACTIVATION IN APERT SYNDROME.REF PROC.NATL.ACAD.SCI.USA V. 98 7182 2001REFN ISSN 0027-8424PMID 11390973DOI 10.1073/PNAS.121183798 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2r53 BMP6 crystal structure analysis of bone morphogenetic protein-6 variant b2 (b2-bmp-6) 2.1Å AUTH S.SAREMBA,J.NICKEL,A.SEHER,A.KOTZSCH,W.SEBALD,AUTH 2 T.D.MUELLERTITL TYPE I RECEPTOR BINDING OF BONE MORPHOGENETICTITL 2 PROTEIN 6 IS DEPENDENT ON N-GLYCOSYLATION OF THETITL 3 LIGAND.REF FEBS J. V. 275 172 2007REFN ISSN 1742-464XPMID 18070108DOI 10.1111/J.1742-4658.2007.06187.X Variant Set Distributions Mapped Variants