Assessment of Structural Intolerance and Durability
General Structure Information 3con NRAS crystal structure of the human nras gtpase bound with gdp 1.65Å AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,L.SHEN,P.LOPPNAU,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE HUMAN NRAS GTPASE BOUNDTITL 2 WITH GDP.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2j3t TRAPPC6A the crystal structure of the bet3-trs33-bet5-trs23 complex. 2.4Å AUTH Y.KIM,S.RAUNSER,C.MUNGER,J.WAGNER,Y.SONG,M.CYGLER,T.WALZ,AUTH 2 B.OH,M.SACHERTITL THE ARCHITECTURE OF THE MULTISUBUNIT TRAPP I COMPLEXTITL 2 SUGGESTS A MODEL FOR VESICLE TETHERING.REF CELL(CAMBRIDGE,MASS.) V. 127 817 2006REFN ISSN 0092-8674PMID 17110339DOI 10.1016/J.CELL.2006.09.029 Variant Set Distributions Mapped Variants
General Structure Information 3eh1 SEC24B crystal structure of the human copii-coat protein sec24b 1.8Å AUTH J.D.MANCIAS,J.GOLDBERGTITL STRUCTURAL BASIS OF CARGO MEMBRANE PROTEINTITL 2 DISCRIMINATION BY THE HUMAN COPII COAT MACHINERY.REF EMBO J. V. 27 2918 2008REFN ISSN 0261-4189PMID 18843296DOI 10.1038/EMBOJ.2008.208 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2w3c USO1 globular head region of the human general vesicular transport factor p115 2.22Å AUTH H.STRIEGL,Y.ROSKE,D.KUMMEL,U.HEINEMANNTITL UNUSUAL ARMADILLO FOLD IN THE HUMAN GENERAL VESICULARTITL 2 TRANSPORT FACTOR P115REF PLOS ONE V. 4 E4656 2009REFN ISSN 1932-6203PMID 19247479DOI 10.1371/JOURNAL.PONE.0004656 Variant Set Distributions Mapped Variants
General Structure Information 3eg9 SEC24D crystal structure of the mammalian copii-coat protein sec23/24 bound to the transport signal sequence of membrin 3.0Å AUTH J.D.MANCIAS,J.GOLDBERGTITL STRUCTURAL BASIS OF CARGO MEMBRANE PROTEIN DISCRIMINATION BYTITL 2 THE HUMAN COPII COAT MACHINERY.REF EMBO J. V. 27 2918 2008REFN ISSN 0261-4189PMID 18843296DOI 10.1038/EMBOJ.2008.208 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3l81 AP4M1 crystal structure of adaptor protein complex 4 (ap-4) mu4 subunit c- terminal domain, in complex with a sorting peptide from the amyloid precursor protein (app) 1.6Å AUTH P.V.BURGOS,G.A.MARDONES,A.L.ROJAS,L.L.DASILVA,Y.PRABHU,AUTH 2 J.H.HURLEY,J.S.BONIFACINOTITL SORTING OF THE ALZHEIMERS DISEASE AMYLOID PRECURSORTITL 2 PROTEIN MEDIATED BY THE AP-4 COMPLEX.REF DEV.CELL V. 18 425 2010REFN ISSN […]
General Structure Information 3iug ARHGAP32 crystal structure of the rhogap domain of rics 1.77Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,Y.LI,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RHOGAP DOMAIN OF RICSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3llk QSOX1 sulfhydryl oxidase fragment of human qsox1 2.0Å AUTH A.ALON,E.J.HECKLER,C.THORPE,D.FASSTITL QSOX CONTAINS A PSEUDO-DIMER OF FUNCTIONAL AND DEGENERATETITL 2 SULFHYDRYL OXIDASE DOMAINS.REF FEBS LETT. V. 584 1521 2010REFN ISSN 0014-5793PMID 20211621DOI 10.1016/J.FEBSLET.2010.03.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants