Assessment of Structural Intolerance and Durability
General Structure Information 3b4v FSTL3 x-ray structure of activin in complex with fstl3 2.48Å AUTH R.STAMLER,H.T.KEUTMANN,Y.SIDIS,C.KATTAMURI,A.SCHNEYER,AUTH 2 T.B.THOMPSONTITL THE STRUCTURE OF FSTL3.ACTIVIN A COMPLEX. DIFFERENTIALTITL 2 BINDING OF N-TERMINAL DOMAINS INFLUENCES FOLLISTATIN-TYPETITL 3 ANTAGONIST SPECIFICITY.REF J.BIOL.CHEM. V. 283 32831 2008REFN ISSN 0021-9258PMID 18768470DOI 10.1074/JBC.M801266200 Variant Set Distributions Mapped Variants
General Structure Information 2wfh SLIT2 the human slit 2 dimerization domain d4 1.8Å AUTH E.SEIRADAKE,A.C.VON PHILIPSBORN,M.HENRY,M.FRITZ,AUTH 2 H.LORTAT-JACOB,M.JAMIN,W.HEMRIKA,M.BASTMEYER,S.CUSACK,AUTH 3 A.A.MCCARTHYTITL STRUCTURE AND FUNCTIONAL RELEVANCE OF THE SLIT2TITL 2 HOMODIMERIZATION DOMAIN.REF EMBO REP. V. 10 736 2009REFN ISSN 1469-221XPMID 19498462DOI 10.1038/EMBOR.2009.95 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2z7x TLR2 crystal structure of the tlr1-tlr2 heterodimer induced by binding of a tri-acylated lipopeptide 2.1Å AUTH M.S.JIN,S.E.KIM,J.Y.HEO,M.E.LEE,H.M.KIM,S.G.PAIK,H.LEE,AUTH 2 J.O.LEETITL CRYSTAL STRUCTURE OF THE TLR1-TLR2 HETERODIMER INDUCED BYTITL 2 BINDING OF A TRI-ACYLATED LIPOPEPTIDEREF CELL(CAMBRIDGE,MASS.) V. 130 1071 2007REFN ISSN 0092-8674PMID 17889651DOI 10.1016/J.CELL.2007.09.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2wo3 EFNA2 crystal structure of the epha4-ephrina2 complex 2.35Å AUTH T.A.BOWDEN,A.R.ARICESCU,J.E.NETTLESHIP,C.SIEBOLD,AUTH 2 N.RAHMAN-HUQ,R.J.OWENS,D.I.STUART,E.Y.JONESTITL STRUCTURAL PLASTICITY OF EPH-RECEPTOR A4 FACILITATESTITL 2 CROSS-CLASS EPHRIN SIGNALLINGREF STRUCTURE V. 17 1386 2009REFN ISSN 0969-2126PMID 19836338DOI 10.1016/J.STR.2009.07.018 Variant Set Distributions Mapped Variants
General Structure Information 2j60 FCN3 h-ficolin complexed to d-fucose 1.8Å AUTH V.GARLATTI,N.BELLOY,L.MARTIN,M.LACROIX,AUTH 2 M.MATSUSHITA,Y.ENDO,T.FUJITA,J.C.FONTECILLA-CAMPS,AUTH 3 G.J.ARLAUD,N.M.THIELENS,C.GABORIAUDTITL STRUCTURAL INSIGHTS INTO THE INNATE IMMUNETITL 2 RECOGNITION SPECIFICITIES OF L- AND H-FICOLINS.REF EMBO J. V. 26 623 2007REFN ISSN 0261-4189PMID 17215869DOI 10.1038/SJ.EMBOJ.7601500 Variant Set Distributions Mapped Variants
General Structure Information 2ch9 CST7 crystal structure of dimeric human cystatin f 2.1Å AUTH A.W.SCHUTTELKOPF,G.HAMILTON,C.WATTS,D.M.F.VAN AALTENTITL STRUCTURAL BASIS OF REDUCTION-DEPENDENT ACTIVATION OF HUMANTITL 2 CYSTATIN F.REF J.BIOL.CHEM. V. 281 16570 2006REFN ISSN 0021-9258PMID 16601115DOI 10.1074/JBC.M601033200 Variant Set Distributions Mapped Variants
General Structure Information 3ee6 TPP1 crystal structure analysis of tripeptidyl peptidase -i 2.35Å AUTH A.PAL,R.KRAETZNER,T.GRUENE,M.GRAPP,K.SCHREIBER,M.GRONBORG,AUTH 2 H.URLAUB,S.BECKER,A.R.ASIF,J.GARTNER,G.M.SHELDRICK,AUTH 3 R.STEINFELDTITL STRUCTURE OF TRIPEPTIDYL-PEPTIDASE I PROVIDES INSIGHT INTOTITL 2 THE MOLECULAR BASIS OF LATE INFANTILE NEURONAL CEROIDTITL 3 LIPOFUSCINOSISREF J.BIOL.CHEM. V. 284 3976 2009REFN ISSN 0021-9258PMID 19038966DOI 10.1074/JBC.M806947200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3dxc APBB1 crystal structure of the intracellular domain of human app in complex with fe65-ptb2 2.1Å AUTH J.RADZIMANOWSKI,B.SIMON,M.SATTLER,K.BEYREUTHER,AUTH 2 I.SINNING,K.WILDTITL STRUCTURE OF THE INTRACELLULAR DOMAIN OF THETITL 2 AMYLOID PRECURSOR PROTEIN IN COMPLEX WITHTITL 3 FE65-PTB2.REF EMBO REP. V. 9 1134 2008REFN ISSN 1469-221XPMID 18833287DOI 10.1038/EMBOR.2008.188 Variant Set Distributions Mapped Variants
General Structure Information 2jju SIRPB1 structure of human signal regulatory protein (sirp) beta 1.19Å AUTH D.HATHERLEY,S.C.GRAHAM,J.TURNER,K.HARLOS,AUTH 2 D.I.STUART,A.N.BARCLAYTITL PAIRED RECEPTOR SPECIFICITY EXPLAINED BYTITL 2 STRUCTURES OF SIGNAL REGULATORY PROTEINS ALONE ANDTITL 3 COMPLEXED WITH CD47.REF MOL.CELL V. 31 266 2008REFN ISSN 1097-2765PMID 18657508DOI 10.1016/J.MOLCEL.2008.05.026 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2qqm NRP1 crystal structure of the a2b1b2 domains from human neuropilin-1 2.0Å AUTH B.A.APPLETON,P.WU,J.MALONEY,J.YIN,W.C.LIANG,S.STAWICKI,AUTH 2 K.MORTARA,K.K.BOWMAN,J.M.ELLIOTT,W.DESMARAIS,J.F.BAZAN,AUTH 3 A.BAGRI,M.TESSIER-LAVIGNE,A.W.KOCH,Y.WU,R.J.WATTS,C.WIESMANNTITL STRUCTURAL STUDIES OF NEUROPILIN/ANTIBODY COMPLEXES PROVIDETITL 2 INSIGHTS INTO SEMAPHORIN AND VEGF BINDINGREF EMBO J. V. 26 4902 2007REFN ISSN 0261-4189PMID 17989695DOI 10.1038/SJ.EMBOJ.7601906 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]