Assessment of Structural Intolerance and Durability
General Structure Information 2jg8 C1QB crystallographic structure of human c1q globular heads complexed to phosphatidyl-serine 2.05Å AUTH H.PAIDASSI,P.TACNET-DELORME,V.GARLATTI,C.DARNAULT,AUTH 2 B.GHEBREHIWET,C.GABORIAUD,G.J.ARLAUD,P.FRACHETTITL C1Q BINDS PHOSPHATIDYLSERINE AND LIKELY ACTS AS ATITL 2 MULTILIGAND-BRIDGING MOLECULE IN APOPTOTIC CELLTITL 3 RECOGNITION.REF J.IMMUNOL. V. 180 2329 2008REFN ISSN 0022-1767PMID 18250442 Variant Set Distributions Mapped Variants
General Structure Information 4kro EGFR nanobody/vhh domain ega1 in complex with the extracellular region of egfr 3.05Å AUTH K.R.SCHMITZ,A.BAGCHI,R.C.ROOVERS,AUTH 2 P.M.VAN BERGEN EN HENEGOUWEN,K.M.FERGUSONTITL STRUCTURAL EVALUATION OF EGFR INHIBITION MECHANISMS FORTITL 2 NANOBODIES/VHH DOMAINS.REF STRUCTURE V. 21 1214 2013REFN ISSN 0969-2126PMID 23791944DOI 10.1016/J.STR.2013.05.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3be1 ERBB2 dual specific bh1 fab in complex with the extracellular domain of her2/erbb-2 2.9Å AUTH J.BOSTROM,S.F.YU,D.KAN,B.A.APPLETON,C.V.LEE,K.BILLECI,W.MAN,AUTH 2 F.PEALE,S.ROSS,C.WIESMANN,G.FUHTITL VARIANTS OF THE ANTIBODY HERCEPTIN THAT INTERACT WITH HER2TITL 2 AND VEGF AT THE ANTIGEN BINDING SITEREF SCIENCE V. 323 1610 2009REFN ISSN 0036-8075PMID 19299620DOI 10.1126/SCIENCE.1165480 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3ij9 AMY2A directed in situ elongation as a strategy to characterize the covalent glycosyl-enzyme catalytic intermediate of human pancreatic a-amylase 1.85Å AUTH R.ZHANG,C.LI,L.K.WILLIAMS,B.P.REMPEL,G.D.BRAYER,AUTH 2 S.G.WITHERSTITL DIRECTED IN SITU INHIBITOR ELONGATION AS ATITL 2 STRATEGY TO STRUCTURALLY CHARACTERIZE THE COVALENTTITL 3 GLYCOSYL-ENZYME INTERMEDIATE OF HUMAN PANCREATICTITL 4 ALPHA-AMYLASEREF BIOCHEMISTRY V. 48 10752 2009REFN […]
General Structure Information 3bt1 PLAU structure of urokinase receptor, urokinase and vitronectin complex 2.8Å AUTH Q.HUAI,A.ZHOU,L.LIN,A.P.MAZAR,G.C.PARRY,J.CALLAHAN,D.E.SHAW,AUTH 2 B.FURIE,B.C.FURIE,M.HUANGTITL CRYSTAL STRUCTURES OF TWO HUMAN VITRONECTIN, UROKINASE ANDTITL 2 UROKINASE RECEPTOR COMPLEXESREF NAT.STRUCT.MOL.BIOL. V. 15 422 2008REFN ISSN 1545-9993PMID 18376415DOI 10.1038/NSMB.1404 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2v70 SLIT2 third lrr domain of human slit2 3.01Å AUTH C.MORLOT,W.HEMRIKA,R.A.ROMIJN,P.GROS,S.CUSACK,A.A.MCCARTHYTITL PRODUCTION OF SLIT2 LRR DOMAINS IN MAMMALIAN CELLS FORTITL 2 STRUCTURAL STUDIES AND THE STRUCTURE OF HUMAN SLIT2 DOMAINTITL 3 3.REF ACTA CRYSTALLOGR.,SECT.D V. 63 961 2007REFN ISSN 0907-4449PMID 17704564DOI 10.1107/S0907444907035470 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3kq4 CUBN structure of intrinsic factor-cobalamin bound to its receptor cubilin 3.3Å AUTH C.B.ANDERSEN,M.MADSEN,T.STORM,S.K.MOESTRUP,G.R.ANDERSENTITL STRUCTURAL BASIS FOR RECEPTOR RECOGNITION OFTITL 2 VITAMIN-B(12)-INTRINSIC FACTOR COMPLEXES.REF NATURE V. 464 445 2010REFN ISSN 0028-0836PMID 20237569DOI 10.1038/NATURE08874 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2qqk NRP2 neuropilin-2 a1a2b1b2 domains in complex with a semaphorin-blocking fab 2.75Å AUTH B.A.APPLETON,P.WU,J.MALONEY,J.YIN,W.C.LIANG,S.STAWICKI,AUTH 2 K.MORTARA,K.K.BOWMAN,J.M.ELLIOTT,W.DESMARAIS,J.F.BAZAN,AUTH 3 A.BAGRI,M.TESSIER-LAVIGNE,A.W.KOCH,Y.WU,R.J.WATTS,C.WIESMANNTITL STRUCTURAL STUDIES OF NEUROPILIN/ANTIBODY COMPLEXES PROVIDETITL 2 INSIGHTS INTO SEMAPHORIN AND VEGF BINDINGREF EMBO J. V. 26 4902 2007REFN ISSN 0261-4189PMID 17989695DOI 10.1038/SJ.EMBOJ.7601906 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3edi TLL1 crystal structure of tolloid-like protease 1 (tll-1) protease domain 1.4Å AUTH A.MAC SWEENEY,S.G.PARRADO,D.VINZENZ,A.BERNARDI,AUTH 2 A.HEIN,U.BODENDORF,P.ERBEL,C.LOGEL,B.GERHARTZTITL STRUCTURAL BASIS FOR THE SUBSTRATE SPECIFICITY OFTITL 2 BONE MORPHOGENETIC PROTEIN 1/TOLLOID-LIKETITL 3 METALLOPROTEASESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2rjp ADAMTS4 crystal structure of adamts4 with inhibitor bound 2.8Å AUTH L.MOSYAK,K.GEORGIADIS,T.SHANE,K.SVENSON,T.HEBERT,AUTH 2 T.MCDONAGH,S.MACKIE,S.OLLAND,L.LIN,X.ZHONG,R.KRIZ,AUTH 3 E.L.REIFENBERG,L.A.COLLINS-RACIE,C.CORCORAN,AUTH 4 B.FREEMAN,R.ZOLLNER,T.MARVELL,M.VERA,P.E.SUM,AUTH 5 E.R.LAVALLIE,M.STAHL,W.SOMERSTITL CRYSTAL STRUCTURES OF THE TWO MAJOR AGGRECANTITL 2 DEGRADING ENZYMES, ADAMTS4 AND ADAMTS5.REF PROTEIN SCI. V. 17 16 2008REFN ISSN 0961-8368PMID 18042673DOI 10.1110/PS.073287008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]