Assessment of Structural Intolerance and Durability
General Structure Information 2ee1 CHD4 solution structures of the chromo domain of human chromodomain helicase-dna-binding protein 4 -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE CHROMO DOMAIN OF HUMANTITL 2 CHROMODOMAIN HELICASE-DNA-BINDING PROTEIN 4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3h8m EPHA7 sam domain of human ephrin type-a receptor 7 (epha7) 2.1Å AUTH J.R.WALKER,L.YERMEKBAYEVA,C.BUTLER-COLE,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL SAM DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 7TITL 2 (EPHA7)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3orh GAMT human guanidinoacetate n-methyltransferase with sah 1.86Å AUTH H.WU,A.DONG,H.ZENG,P.LOPPNAU,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN GUANIDINOACETATETITL 2 N-METHYLTRANSFERASE WITH SAHREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3dlm SETDB1 crystal structure of tudor domain of human histone-lysine n- methyltransferase setdb1 1.77Å AUTH L.DOMBROVSKI,M.F.AMAYA,P.LOPPNAU,A.BOCHKAREV,J.MIN,AUTH 2 H.WUTITL THE CRYSTAL STRUCTURE OF TUDOR DOMAIN OF HUMANTITL 2 HISTONE-LYSINE N-METHYLTRANSFERASE SETDB1.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2oo1 BRD3 crystal structure of the bromo domain 2 of human bromodomain containing protein 3 (brd3) 1.7Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1ujy ARHGEF6 solution structure of sh3 domain in rac/cdc42 guanine nucleotide exchange factor(gef) 6 -1.0Å AUTH F.HE,Y.MUTO,H.UDA,S.KOSHIBA,M.SHIROUZU,T.TERADA,AUTH 2 T.KIGAWA,M.INOUE,T.YABUKI,M.AOKI,E.SEKI,T.MATSUDA,AUTH 3 H.HIROTA,M.YOSHIDA,N.KOBAYASHI,A.TANAKA,T.OSANAI,AUTH 4 Y.MATSUO,O.OHARA,T.NAGASE,R.KIKUNO,M.NAGAYAMA,AUTH 5 S.YOKOYAMATITL SOLUTION STRUCTURE OF SH3 DOMAIN IN RAC/CDC42TITL 2 GUANINE NUCLEOTIDE EXCHANGE FACTOR(GEF) 6REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4f7b SCARB2 structure of the lysosomal domain of limp-2 3.0Å AUTH D.NECULAI,M.SCHWAKE,M.RAVICHANDRAN,F.ZUNKE,R.F.COLLINS,AUTH 2 J.PETERS,M.NECULAI,J.PLUMB,P.LOPPNAU,J.C.PIZARRO,A.SEITOVA,AUTH 3 W.S.TRIMBLE,P.SAFTIG,S.GRINSTEIN,S.DHE-PAGANONTITL STRUCTURE OF LIMP-2 PROVIDES FUNCTIONAL INSIGHTS WITHTITL 2 IMPLICATIONS FOR SR-BI AND CD36.REF NATURE V. 504 172 2013REFN ISSN 0028-0836PMID 24162852DOI 10.1038/NATURE12684 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2emw ZNF268 solution structure of the c2h2 type zinc finger (region 301- 331) of human zinc finger protein 268 -1.0Å AUTH N.TOCHIO,T.TOMIZAWA,H.ABE,K.SAITO,H.LI,M.SATO,AUTH 2 S.KOSHIBA,N.KOBAYASHI,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C2H2 TYPE ZINC FINGERTITL 2 (REGION 301-331) OF HUMAN ZINC FINGER PROTEIN 268REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3fb2 SPTAN1 crystal structure of the human brain alpha spectrin repeats 15 and 16. northeast structural genomics consortium target hr5563a. 2.3Å AUTH S.M.VOROBIEV,M.SU,J.SEETHARAMAN,R.SHASTRY,AUTH 2 E.L.FOOTE,C.CICCOSANTI,H.JANJUA,R.XIAO,T.B.ACTON,AUTH 3 G.T.MONTELIONE,L.TONG,J.F.HUNTTITL CRYSTAL STRUCTURE OF THE HUMAN BRAIN ALPHATITL 2 SPECTRIN REPEATS 15 AND 16.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3sm9 GRM3 crystal structure of metabotropic glutamate receptor 3 precursor in presence of ly341495 antagonist 2.26Å AUTH A.K.WERNIMONT,A.DONG,A.SEITOVA,L.CROMBET,G.KHUTORESKAYA,AUTH 2 A.M.EDWARDS,C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,D.COSSAR,AUTH 3 E.DOBROVETSKYTITL CRYSTAL STRUCTURE OF METABOTROPIC GLUTAMATE RECEPTOR 3TITL 2 PRECURSOR IN PRESENCE OF LY341495 ANTAGONISTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]