Assessment of Structural Intolerance and Durability
General Structure Information 2ean CNKSR2 solution structure of the n-terminal sam-domain of human kiaa0902 protein (connector enhancer of kinase suppressor of ras 2) -1.0Å AUTH A.K.GORONCY,M.YONEYAMA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERMINAL SAM-DOMAIN OFTITL 2 HUMAN KIAA0902 PROTEIN (CONNECTOR ENHANCER OFTITL 3 KINASE SUPPRESSOR OF RAS 2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped […]
General Structure Information 1uen NRCAM solution structure of the third fibronectin iii domain of human kiaa0343 protein -1.0Å AUTH K.MIYAMOTO,T.KIGAWA,F.HAYASHI,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD FIBRONECTIN IIITITL 2 DOMAIN OF HUMAN KIAA0343 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1yzg ARL5B structure of human adp-ribosylation factor-like 8 2.0Å AUTH A.ATANASSOVA,J.CHOE,C.ARROWSMITH,A.EDWARDS,AUTH 2 M.SUNDSTROM,A.BOCHKAREV,H.PARKTITL STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR-LIKE 8REF TO BE PUBLISHED 2005REFN Variant Set Distributions Mapped Variants
General Structure Information 1zd9 ARL8A structure of human adp-ribosylation factor-like 10b 1.7Å AUTH A.ATANASSOVA,J.CHOE,C.ARROWSMITH,A.EDWARDS,AUTH 2 M.SUNDSTROM,A.BOCHKAREV,H.PARKTITL STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR-LIKE 10BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3tht ALKBH8 crystal structure and rna binding properties of the rrm/alkb domains in human abh8, an enzyme catalyzing trna hypermodification, northeast structural genomics consortium target hr5601b 3.01Å AUTH C.PASTORE,I.TOPALIDOU,F.FOROUHAR,A.C.YAN,M.LEVY,J.F.HUNTTITL CRYSTAL STRUCTURE AND RNA BINDING PROPERTIES OF THE RNATITL 2 RECOGNITION MOTIF (RRM) AND ALKB DOMAINS IN HUMAN ALKBTITL 3 HOMOLOG 8 (ABH8), […]
General Structure Information 2dm3 PALLD solution structure of the second ig domain of human palladin -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND IG DOMAIN OFTITL 2 HUMAN PALLADINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kvw DYRK2 crystal structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (dyrk2) in complex with an indirubin ligand 2.28Å AUTH P.FILIPPAKOPOULOS,V.MYRIANTHOPOULOS,M.KRITSANIDA,P.MAGIATIS,AUTH 2 A.L.SKALTSOUNIS,M.SOUNDARARAJAN,T.KROJER,O.GILEADI,E.HAPKA,AUTH 3 O.FEDOROV,G.BERRIDGE,J.WANG,L.SHRESTHA,M.VOLLMAR,AUTH 4 F.VON DELFT,C.H.ARROWSMITH,A.EDWARDS,J.WEIGELT,C.BOUNTRA,AUTH 5 E.MIKROS,S.KNAPPTITL CRYSTAL STRUCTURE OF DUAL-SPECIFICITY TYROSINETITL 2 PHOSPHORYLATION REGULATED KINASE 2 (DYRK2) IN COMPLEX WITHTITL 3 AN INDIRUBIN LIGANDREF TO BE PUBLISHEDREFN Variant […]
General Structure Information 3b7k ACOT12 human acyl-coenzyme a thioesterase 12 2.7Å AUTH L.LEHTIO,R.D.BUSAM,C.H.ARROWSMITH,R.COLLINS,L.G.DAHLGREN,AUTH 2 A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,AUTH 3 B.M.HALLBERG,M.D.HERMAN,A.JOHANSSON,I.JOHANSSON,A.KALLAS,AUTH 4 T.KARLBERG,T.KOTENYOVA,M.MOCHE,M.E.NILSSON,P.NORDLUND,AUTH 5 T.NYMAN,C.PERSSON,J.SAGEMARK,M.SUNDSTROM,SVENSSON L.,AUTH 6 A.G.THORSELL,L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,AUTH 7 H.BERGLUNDTITL HUMAN ACYL-COENZYME A THIOESTERASE 12.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3me9 CCDC101 crystal structure of sgf29 in complex with h3k4me3 peptide 1.37Å AUTH C.BIAN,C.XU,J.RUAN,K.K.LEE,T.L.BURKE,W.TEMPEL,D.BARSYTE,AUTH 2 J.LI,M.WU,B.O.ZHOU,B.E.FLEHARTY,A.PAULSON,A.ALLALI-HASSANI,AUTH 3 J.Q.ZHOU,G.MER,P.A.GRANT,J.L.WORKMAN,J.ZANG,J.MINTITL SGF29 BINDS HISTONE H3K4ME2/3 AND IS REQUIRED FOR SAGATITL 2 COMPLEX RECRUITMENT AND HISTONE H3 ACETYLATION.REF EMBO J. V. 30 2829 2011REFN ISSN 0261-4189PMID 21685874DOI 10.1038/EMBOJ.2011.193 Variant Set Distributions Mapped Variants
General Structure Information 2a2n PPWD1 crystal structure of the peptidylprolyl isomerase domain of human ppwd1 1.65Å AUTH T.L.DAVIS,J.R.WALKER,H.OUYANG,F.MACKENZIE,C.BUTLER-COLE,AUTH 2 E.M.NEWMAN,E.Z.EISENMESSER,S.DHE-PAGANONTITL THE CRYSTAL STRUCTURE OF HUMAN WD40 REPEAT-CONTAININGTITL 2 PEPTIDYLPROLYL ISOMERASE (PPWD1).REF FEBS J. V. 275 2283 2008REFN ISSN 1742-464XPMID 18397323DOI 10.1111/J.1742-4658.2008.06381.X Variant Set Distributions Mapped Variants