Assessment of Structural Intolerance and Durability
General Structure Information 2h57 ARL6 crystal structure of human adp-ribosylation factor-like 6 2.0Å AUTH J.WANG,Y.SHEN,W.TEMPEL,R.LANDRY,J.LEW,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN ADP-RIBOSYLATIONTITL 2 FACTOR-LIKE 6 (CASP TARGET)REF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1zd1 SULT4A1 human sulfortransferase sult4a1 2.24Å AUTH A.ALLALI-HASSANI,P.W.PAN,L.DOMBROVSKI,R.NAJMANOVICH,AUTH 2 W.TEMPEL,A.DONG,P.LOPPNAU,F.MARTIN,J.THORNTON,J.THONTON,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOV,M.VEDADI,AUTH 4 C.H.ARROWSMITHTITL STRUCTURAL AND CHEMICAL PROFILING OF THE HUMAN CYTOSOLICTITL 2 SULFOTRANSFERASES.REF PLOS BIOL. V. 5 E97 2007REFN ISSN 1544-9173PMID 17425406DOI 10.1371/JOURNAL.PBIO.0050097 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ovj RACGAP1 the crystal structure of the human rac gtpase activating protein 1 (racgap1) mgcracgap. 1.49Å AUTH L.SHRESTHA,E.PAPAGRIGORIOU,M.SOUNDARARAJAN,J.ELKINS,AUTH 2 C.JOHANSSON,F.VON DELFT,A.C.W.PIKE,N.BURGESS,A.TURNBULL,AUTH 3 J.DEBRECZENI,F.GORREC,C.UMEANO,A.EDWARDS,C.H.ARROWSMITH,AUTH 4 J.WEIGELT,M.SUNDSTROM,D.A.DOYLETITL THE CRYSTAL STRUCTURE OF THE HUMAN RAC GTPASE ACTIVATINGTITL 2 PROTEIN 1 (RACGAP1) MGCRACGAP.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lnb ZBP1 solution nmr structure of n-terminal domain (6-74) of human zbp1 protein, northeast structural genomics consortium target hr8174a. -1.0Å AUTH Y.YANG,T.A.RAMELOT,K.HAMILTON,E.KOHAN,D.WANG,T.B.ACTON,AUTH 2 R.XIAO,J.K.EVERETT,G.T.MONTELIONE,M.A.KENNEDYTITL SOLUTION NMR STRUCTURE OF N-TERMINAL DOMAIN (6-74) OF HUMANTITL 2 ZBP1 PROTEIN, NORTHEAST STRUCTURAL GENOMICS CONSORTIUMTITL 3 TARGET HR8174AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ag5 BDH2 crystal structure of human dhrs6 1.84Å AUTH K.GUO,P.LUKACIK,E.PAPAGRIGORIOU,M.MEIER,W.H.LEE,J.ADAMSKI,AUTH 2 U.OPPERMANNTITL CHARACTERIZATION OF HUMAN DHRS6, AN ORPHAN SHORT CHAINTITL 2 DEHYDROGENASE/REDUCTASE ENZYME: A NOVEL, CYTOSOLIC TYPE 2TITL 3 R-BETA-HYDROXYBUTYRATE DEHYDROGENASEREF J.BIOL.CHEM. V. 281 10291 2006REFN ISSN 0021-9258PMID 16380372DOI 10.1074/JBC.M511346200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4n4w SMO structure of the human smoothened receptor in complex with sant-1. 2.8Å AUTH C.WANG,H.WU,T.EVRON,E.VARDY,G.W.HAN,X.P.HUANG,S.J.HUFEISEN,AUTH 2 T.J.MANGANO,D.J.URBAN,V.KATRITCH,V.CHEREZOV,M.G.CARON,AUTH 3 B.L.ROTH,R.C.STEVENSTITL STRUCTURAL BASIS FOR SMOOTHENED RECEPTOR MODULATION ANDTITL 2 CHEMORESISTANCE TO ANTICANCER DRUGS.REF NAT COMMUN V. 5 4355 2014REFN ESSN 2041-1723PMID 25008467DOI 10.1038/NCOMMS5355 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3h8v UBA5 human ubiquitin-activating enzyme 5 in complex with atp 2.0Å AUTH J.P.BACIK,J.R.WALKER,M.ALI,A.D.SCHIMMER,S.DHE-PAGANONTITL CRYSTAL STRUCTURE OF THE HUMAN UBIQUITIN-ACTIVATING ENZYME 5TITL 2 (UBA5) BOUND TO ATP: MECHANISTIC INSIGHTS INTO ATITL 3 MINIMALISTIC E1 ENZYME.REF J.BIOL.CHEM. V. 285 20273 2010REFN ISSN 0021-9258PMID 20368332DOI 10.1074/JBC.M110.102921 Variant Set Distributions Mapped Variants
General Structure Information 2efl FNBP1 crystal structure of the efc domain of formin-binding protein 17 2.61Å AUTH A.SHIMADA,H.NIWA,K.TSUJITA,S.SUETSUGU,K.NITTA,AUTH 2 K.HANAWA-SUETSUGU,R.AKASAKA,Y.NISHINO,M.TOYAMA,L.CHEN,AUTH 3 Z.-J.LIU,B.-C.WANG,M.YAMAMOTO,T.TERADA,A.MIYAZAWA,A.TANAKA,AUTH 4 S.SUGANO,M.SHIROUZU,K.NAGAYAMA,T.TAKENAWA,S.YOKOYAMATITL CURVED EFC/F-BAR-DOMAIN DIMERS ARE JOINED END TO END INTO ATITL 2 FILAMENT FOR MEMBRANE INVAGINATION IN ENDOCYTOSISREF CELL(CAMBRIDGE,MASS.) V. 129 761 2007REFN ISSN 0092-8674PMID 17512409DOI 10.1016/J.CELL.2007.03.040 Variant Set Distributions Ripley’s K […]
General Structure Information 2b25 TRMT61B human putative trna(1-methyladenosine)methyltransferase 2.5Å AUTH H.WU,W.TEMPEL,A.DONG,H.ZENG,P.LOPPNAU,C.ARROWSMITH,AUTH 2 A.EDWARDS,J.WEIGELT,M.SUNDSTROM,A.BOCHKAREV,A.N.PLOTNIKOVTITL HUMAN PUTATIVE TRNA(1-METHYLADENOSINE)METHYLTRANSFERASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3o4r DHRS4 crystal structure of human dehydrogenase/reductase (sdr family) member 4 (dhrs4) 1.7Å AUTH E.UGOCHUKWU,C.BHATIA,T.KROJER,M.VOLLMAR,W.W.YUE,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,F.VON DELFT,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN DEHYDROGENASE/REDUCTASE (SDRTITL 2 FAMILY) MEMBER 4 (DHRS4)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants