Assessment of Structural Intolerance and Durability
General Structure Information 3v8o FLNC human filamin c ig – like domains 4 and 5 2.8Å AUTH R.SETHI,J.SEPPALA,H.TOSSAVAINEN,M.YLILAURI,S.RUSKAMO,AUTH 2 O.T.PENTIKAINEN,U.PENTIKAINEN,P.PERMI,J.YLANNETITL A NOVEL STRUCTURAL UNIT IN THE N-TERMINAL REGION OFTITL 2 FILAMINS.REF J.BIOL.CHEM. V. 289 8588 2014REFN ISSN 0021-9258PMID 24469451DOI 10.1074/JBC.M113.537456 Variant Set Distributions Mapped Variants
General Structure Information 3v8o FLNC human filamin c ig – like domains 4 and 5 2.8Å AUTH R.SETHI,J.SEPPALA,H.TOSSAVAINEN,M.YLILAURI,S.RUSKAMO,AUTH 2 O.T.PENTIKAINEN,U.PENTIKAINEN,P.PERMI,J.YLANNETITL A NOVEL STRUCTURAL UNIT IN THE N-TERMINAL REGION OFTITL 2 FILAMINS.REF J.BIOL.CHEM. V. 289 8588 2014REFN ISSN 0021-9258PMID 24469451DOI 10.1074/JBC.M113.537456 Variant Set Distributions Mapped Variants
General Structure Information 2d7q FLNC solution structure of the 23th filamin domain from human filamin c -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 23TH FILAMIN DOMAIN FROMTITL 2 HUMAN FILAMIN CREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1xtj DDX39B structure of human uap56 in complex with adp 2.7Å AUTH H.SHI,O.CORDIN,C.M.MINDER,P.LINDER,R.-M.XUTITL CRYSTAL STRUCTURE OF THE HUMAN ATP-DEPENDENTTITL 2 SPLICING AND EXPORT FACTOR UAP56REF PROC.NATL.ACAD.SCI.USA V. 101 17628 2004REFN ISSN 0027-8424PMID 15585580DOI 10.1073/PNAS.0408172101 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4gwr PDIA6 crystal structure of the second catalytic domain of protein disulfide isomerase p5 1.81Å AUTH R.VINAIK,G.KOZLOV,K.GEHRINGTITL TO BE PUBLISHEDREF TO BE PUBLISHED 2013REFN Variant Set Distributions Mapped Variants
General Structure Information 4gwr PDIA6 crystal structure of the second catalytic domain of protein disulfide isomerase p5 1.81Å AUTH R.VINAIK,G.KOZLOV,K.GEHRINGTITL TO BE PUBLISHEDREF TO BE PUBLISHED 2013REFN Variant Set Distributions Mapped Variants
General Structure Information 4gwr PDIA6 crystal structure of the second catalytic domain of protein disulfide isomerase p5 1.81Å AUTH R.VINAIK,G.KOZLOV,K.GEHRINGTITL TO BE PUBLISHEDREF TO BE PUBLISHED 2013REFN Variant Set Distributions Mapped Variants
General Structure Information 3vww PDIA6 crystal structure of a0-domain of p5 from h. sapiens 1.93Å AUTH Y.SATO,R.KOJIMA,M.OKUMURA,M.HAGIWARA,S.MASUI,K.MAEGAWA,AUTH 2 M.SAIKI,T.HORIBE,M.SUZUKI,K.INABATITL SYNERGISTIC COOPERATION OF PDI FAMILY MEMBERS INTITL 2 PEROXIREDOXIN 4-DRIVEN OXIDATIVE PROTEIN FOLDINGREF SCI REP V. 3 2456 2013REFN ESSN 2045-2322PMID 23949117DOI 10.1038/SREP02456 Variant Set Distributions Mapped Variants
General Structure Information 4mp7 PDK2 crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor pa7 1.8Å AUTH S.C.TSO,X.QI,W.J.GUI,C.Y.WU,J.L.CHUANG,AUTH 2 I.WERNSTEDT-ASTERHOLM,L.K.MORLOCK,K.R.OWENS,P.E.SCHERER,AUTH 3 N.S.WILLIAMS,U.K.TAMBAR,R.M.WYNN,D.T.CHUANGTITL STRUCTURE-GUIDED DEVELOPMENT OF SPECIFIC PYRUVATETITL 2 DEHYDROGENASE KINASE INHIBITORS TARGETING THE ATP-BINDINGTITL 3 POCKET.REF J.BIOL.CHEM. V. 289 4432 2014REFN ISSN 0021-9258PMID 24356970DOI 10.1074/JBC.M113.533885 Variant Set Distributions Mapped Variants
General Structure Information 4mp7 PDK2 crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor pa7 1.8Å AUTH S.C.TSO,X.QI,W.J.GUI,C.Y.WU,J.L.CHUANG,AUTH 2 I.WERNSTEDT-ASTERHOLM,L.K.MORLOCK,K.R.OWENS,P.E.SCHERER,AUTH 3 N.S.WILLIAMS,U.K.TAMBAR,R.M.WYNN,D.T.CHUANGTITL STRUCTURE-GUIDED DEVELOPMENT OF SPECIFIC PYRUVATETITL 2 DEHYDROGENASE KINASE INHIBITORS TARGETING THE ATP-BINDINGTITL 3 POCKET.REF J.BIOL.CHEM. V. 289 4432 2014REFN ISSN 0021-9258PMID 24356970DOI 10.1074/JBC.M113.533885 Variant Set Distributions Mapped Variants