Assessment of Structural Intolerance and Durability
General Structure Information 1ovz FCAR crystal structure of human fcari 3.0Å AUTH A.B.HERR,E.R.BALLISTER,P.J.BJORKMANTITL INSIGHTS INTO IGA-MEDIATED IMMUNE RESPONSES FROM THE CRYSTALTITL 2 STRUCTURES OF HUMAN FC-ALPHA-RI AND ITS COMPLEX WITH IGA1-FCREF NATURE V. 423 614 2003REFN ISSN 0028-0836PMID 12768205DOI 10.1038/NATURE01685 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1j89 FCER1A human high affinity fc receptor fc(epsilon)ri(alpha), tetragonal crystal form 2 4.1Å AUTH S.C.GARMAN,S.SECHI,J.P.KINET,T.S.JARDETZKYTITL THE ANALYSIS OF THE HUMAN HIGH AFFINITY IGE RECEPTOR FCTITL 2 EPSILON RI ALPHA FROM MULTIPLE CRYSTAL FORMS.REF J.MOL.BIOL. V. 311 1049 2001REFN ISSN 0022-2836PMID 11531339DOI 10.1006/JMBI.2001.4929 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3ry6 FCGR2A complex of fcgammariia (cd32) and the fc of human igg1 3.8Å AUTH P.A.RAMSLAND,W.FARRUGIA,T.M.BRADFORD,C.T.SARDJONO,S.ESPARON,AUTH 2 H.M.TRIST,M.S.POWELL,P.S.TAN,A.C.CENDRON,B.D.WINES,AUTH 3 A.M.SCOTT,P.M.HOGARTHTITL STRUCTURAL BASIS FOR FC{GAMMA}RIIA RECOGNITION OF HUMAN IGGTITL 2 AND FORMATION OF INFLAMMATORY SIGNALING COMPLEXES.REF J.IMMUNOL. V. 187 3208 2011REFN ISSN 0022-1767PMID 21856937DOI 10.4049/JIMMUNOL.1101467 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3sgj FCGR3A unique carbohydrate-carbohydrate interactions are required for high affinity binding between fcgiii and antibodies lacking core fucose 2.2Å AUTH C.FERRARA,S.GRAU,C.JAGER,P.SONDERMANN,P.BRUNKER,I.WALDHAUER,AUTH 2 M.HENNIG,A.RUF,A.C.RUFER,M.STIHLE,P.UMANA,J.BENZTITL UNIQUE CARBOHYDRATE-CARBOHYDRATE INTERACTIONS ARE REQUIREDTITL 2 FOR HIGH AFFINITY BINDING BETWEEN FCGAMMARIII AND ANTIBODIESTITL 3 LACKING CORE FUCOSE.REF PROC.NATL.ACAD.SCI.USA V. 108 12669 2011REFN ISSN 0027-8424PMID 21768335DOI 10.1073/PNAS.1108455108 Variant Set […]