Assessment of Structural Intolerance and Durability
General Structure Information 2pon BCL2L1 solution structure of the bcl-xl/beclin-1 complex -1.0Å AUTH W.FENG,S.HUANG,H.WU,M.ZHANGTITL MOLECULAR BASIS OF BCL-XLS TARGET RECOGNITIONTITL 2 VERSATILITY REVEALED BY THE STRUCTURE OF BCL-XL INTITL 3 COMPLEX WITH THE BH3 DOMAIN OF BECLIN-1.REF J.MOL.BIOL. V. 372 223 2007REFN ISSN 0022-2836PMID 17659302DOI 10.1016/J.JMB.2007.06.069 Variant Set Distributions Mapped Variants
General Structure Information 2ee5 ARHGAP5 solution structure of the n-teruminus extended rhogap domain from human rho gtpase activating protein 5 variant -1.0Å AUTH T.TOMIZAWA,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERUMINUS EXTENDEDTITL 2 RHOGAP DOMAIN FROM HUMAN RHO GTPASE ACTIVATINGTITL 3 PROTEIN 5 VARIANTREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1rhf TYRO3 crystal structure of human tyro3-d1d2 1.96Å AUTH C.HEIRING,B.DAHLBACK,Y.A.MULLERTITL LIGAND RECOGNITION AND HOMOPHILIC INTERACTIONS IN TYRO3:TITL 2 STRUCTURAL INSIGHTS INTO THE AXL/TYRO3 RECEPTOR TYROSINETITL 3 KINASE FAMILY.REF J.BIOL.CHEM. V. 279 6952 2004REFN ISSN 0021-9258PMID 14623883DOI 10.1074/JBC.M311750200 Variant Set Distributions Mapped Variants
General Structure Information 3gut RELA crystal structure of a higher-order complex of p50:rela bound to the hiv-1 ltr 3.59Å AUTH J.C.STROUD,A.OLTMAN,A.HAN,D.L.BATES,L.CHENTITL STRUCTURAL BASIS OF HIV-1 ACTIVATION BYTITL 2 NF-KAPPAB–A HIGHER-ORDER COMPLEX OF P50:RELA BOUNDTITL 3 TO THE HIV-1 LTR.REF J.MOL.BIOL. V. 393 98 2009REFN ISSN 0022-2836PMID 19683540DOI 10.1016/J.JMB.2009.08.023 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3dtc MAP3K9 crystal structure of mixed-lineage kinase mlk1 complexed with compound 16 2.6Å AUTH R.L.HUDKINS,J.L.DIEBOLD,M.TAO,K.A.JOSEF,C.H.PARK,AUTH 2 T.S.ANGELES,L.D.AIMONE,J.HUSTEN,M.A.ATOR,S.L.MEYER,AUTH 3 B.P.HOLSKIN,J.T.DURKIN,A.A.FEDOROV,E.V.FEDOROV,AUTH 4 S.C.ALMO,J.R.MATHIASEN,D.BOZYCZKO-COYNE,AUTH 5 M.S.SAPORITO,R.W.SCOTT,J.P.MALLAMOTITL MIXED-LINEAGE KINASE 1 AND MIXED-LINEAGE KINASE 3TITL 2 SUBTYPE-SELECTIVETITL 3 DIHYDRONAPHTHYL[3,4-A]PYRROLO[3,4-C]CARBAZOLE-5-TITL 4 ONES: OPTIMIZATION, MIXED-LINEAGE KINASE 1TITL 5 CRYSTALLOGRAPHY, AND ORAL IN VIVO ACTIVITY INTITL 6 1-METHYL-4-PHENYLTETRAHYDROPYRIDINE MODELS.REF J.MED.CHEM. […]
General Structure Information 3l6a EIF4G2 crystal structure of the c-terminal region of human p97 2.0Å AUTH S.FAN,M.JIA,W.GONGTITL CRYSTAL STRUCTURE OF THE C-TERMINAL REGION OF HUMANTITL 2 P97/DAP5REF PROTEINS 2010REFN ESSN 1097-0134DOI 10.1002/PROT.22735 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2m0p LRP2 solution structure of the tenth complement type repeat of human megalin -1.0Å AUTH R.DAGIL,C.OSHEA,A.NYKJAR,A.M.BONVIN,B.B.KRAGELUNDTITL GENTAMICIN BINDS TO THE MEGALIN RECEPTOR AS A COMPETITIVETITL 2 INHIBITOR USING THE COMMON LIGAND BINDING MOTIF OFTITL 3 COMPLEMENT TYPE REPEATS: INSIGHT FROM THE NMR STRUCTURE OFTITL 4 THE 10TH COMPLEMENT TYPE REPEAT DOMAIN ALONE […]
General Structure Information 1w8m PPIA enzymatic and structural characterisation of non peptide ligand cyclophilin complexes 1.65Å AUTH G.KONTOPIDIS,P.TAYLOR,M.WALKINSHAWTITL ENZYMATIC AND STRUCTURAL CHARACTERIZATION OFTITL 2 NON-PEPTIDE LIGAND-CYCLOPHILIN COMPLEXESREF ACTA CRYSTALLOGR.,SECT.D V. 60 479 2004REFN ISSN 0907-4449PMID 14993672DOI 10.1107/S0907444904000174 Variant Set Distributions Mapped Variants
General Structure Information 2dm1 VAV2 solution structure of the second sh3 domain of human protein vav-2 -1.0Å AUTH H.ENDO,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND SH3 DOMAIN OFTITL 2 HUMAN PROTEIN VAV-2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2qkh GIPR crystal structure of the extracellular domain of human gip receptor in complex with the hormone gip 1.9Å AUTH C.PARTHIER,M.KLEINSCHMIDT,P.NEUMANN,R.RUDOLPH,AUTH 2 S.MANHART,D.SCHLENZIG,J.FANGHANEL,J.-U.RAHFELD,AUTH 3 H.-U.DEMUTH,M.T.STUBBSTITL CRYSTAL STRUCTURE OF THE INCRETIN-BOUNDTITL 2 EXTRACELLULAR DOMAIN OF A G PROTEIN-COUPLEDTITL 3 RECEPTORREF PROC.NATL.ACAD.SCI.USA V. 104 13942 2007REFN ISSN 0027-8424PMID 17715056DOI 10.1073/PNAS.0706404104 Variant Set Distributions Ripley’s […]