Assessment of Structural Intolerance and Durability
General Structure Information 3hr4 NOS2 human inos reductase and calmodulin complex 2.5Å AUTH C.XIA,I.MISRA,T.IYANAKI,J.J.K.KIMTITL REGULATION OF INTERDOMAIN INTERACTIONS BY CAM IN INDUCIBLETITL 2 NITRIC OXIDE SYNTHASEREF J.BIOL.CHEM. 2009REFN ESSN 1083-351X Variant Set Distributions Mapped Variants
General Structure Information 3e7g NOS2 structure of human inosox with inhibitor ar-c95791 2.2Å AUTH E.D.GARCIN,A.S.ARVAI,R.J.ROSENFELD,M.D.KROEGER,AUTH 2 B.R.CRANE,G.ANDERSSON,G.ANDREWS,P.J.HAMLEY,AUTH 3 P.R.MALLINDER,D.J.NICHOLLS,S.A.ST-GALLAY,AUTH 4 A.C.TINKER,N.P.GENSMANTEL,A.METE,D.R.CHESHIRE,AUTH 5 S.CONNOLLY,D.J.STUEHR,A.ABERG,A.V.WALLACE,AUTH 6 J.A.TAINER,E.D.GETZOFFTITL ANCHORED PLASTICITY OPENS DOORS FOR SELECTIVETITL 2 INHIBITOR DESIGN IN NITRIC OXIDE SYNTHASE.REF NAT.CHEM.BIOL. V. 4 700 2008REFN ISSN 1552-4450PMID 18849972DOI 10.1038/NCHEMBIO.115 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2v60 MAOB structure of human mao b in complex with the selective inhibitor 7-(3-chlorobenzyloxy)-4-carboxaldehyde-coumarin 2.0Å AUTH C.BINDA,J.WANG,L.PISANI,C.CACCIA,A.CAROTTI,AUTH 2 P.SALVATI,D.E.EDMONDSON,A.MATTEVITITL STRUCTURES OF HUMAN MONOAMINE OXIDASE B COMPLEXESTITL 2 WITH SELECTIVE NONCOVALENT INHIBITORS: SAFINAMIDETITL 3 AND COUMARIN ANALOGS.REF J.MED.CHEM. V. 50 5848 2007REFN ISSN 0022-2623PMID 17915852DOI 10.1021/JM070677Y Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3qfc POR crystal structure of human nadph-cytochrome p450 (v492e mutant) 1.8Å AUTH C.XIA,S.P.PANDA,C.C.MAROHNIC,P.MARTASEK,B.S.MASTERS,J.J.KIMTITL STRUCTURAL BASIS FOR HUMAN NADPH-CYTOCHROME P450TITL 2 OXIDOREDUCTASE DEFICIENCY.REF PROC.NATL.ACAD.SCI.USA V. 108 13486 2011REFN ISSN 0027-8424PMID 21808038DOI 10.1073/PNAS.1106632108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3owh NQO2 x-ray structural study of quinone reductase ii inhibition by compounds with micromolar to nanomolar range ic50 values 2.28Å AUTH S.D.PEGAN,M.STURDY,G.FERRY,P.DELAGRANGE,J.A.BOUTIN,AUTH 2 A.D.MESECARTITL X-RAY STRUCTURAL STUDIES OF QUINONE REDUCTASE 2 NANOMOLARTITL 2 RANGE INHIBITORS.REF PROTEIN SCI. V. 20 1182 2011REFN ISSN 0961-8368PMID 21538647DOI 10.1002/PRO.647 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2vig ACADS crystal structure of human short-chain acyl coa dehydrogenase 1.9Å AUTH A.C.W.PIKE,N.PANTIC,E.PARIZOTTO,O.GILEADI,AUTH 2 E.UGOCHUKWU,F.VON DELFT,J.WEIGELT,C.H.ARROWSMITH,AUTH 3 A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN SHORT-CHAIN ACYL COATITL 2 DEHYDROGENASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3llk QSOX1 sulfhydryl oxidase fragment of human qsox1 2.0Å AUTH A.ALON,E.J.HECKLER,C.THORPE,D.FASSTITL QSOX CONTAINS A PSEUDO-DIMER OF FUNCTIONAL AND DEGENERATETITL 2 SULFHYDRYL OXIDASE DOMAINS.REF FEBS LETT. V. 584 1521 2010REFN ISSN 0014-5793PMID 20211621DOI 10.1016/J.FEBSLET.2010.03.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants