Assessment of Structural Intolerance and Durability
General Structure Information 4h6y FARP1 crystal strucure of the dh-ph-ph domain of farp1 4.09Å AUTH X.HE,Y.C.KUO,T.J.ROSCHE,X.ZHANGTITL STRUCTURAL BASIS FOR AUTOINHIBITION OF THE GUANINETITL 2 NUCLEOTIDE EXCHANGE FACTOR FARP2.REF STRUCTURE V. 21 355 2013REFN ISSN 0969-2126PMID 23375260DOI 10.1016/J.STR.2013.01.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1txu RABGEF1 crystal structure of the vps9 domain of rabex-5 2.35Å AUTH A.DELPRATO,E.MERITHEW,D.G.LAMBRIGHTTITL STRUCTURE, EXCHANGE DETERMINANTS, AND FAMILY-WIDETITL 2 RAB SPECIFICITY OF THE TANDEM HELICAL BUNDLE ANDTITL 3 VPS9 DOMAINS OF RABEX-5REF CELL(CAMBRIDGE,MASS.) V. 118 607 2004REFN ISSN 0092-8674PMID 15339665DOI 10.1016/J.CELL.2004.08.009 Variant Set Distributions Mapped Variants
General Structure Information 1txu KCTD7 crystal structure of the vps9 domain of rabex-5 2.35Å AUTH A.DELPRATO,E.MERITHEW,D.G.LAMBRIGHTTITL STRUCTURE, EXCHANGE DETERMINANTS, AND FAMILY-WIDETITL 2 RAB SPECIFICITY OF THE TANDEM HELICAL BUNDLE ANDTITL 3 VPS9 DOMAINS OF RABEX-5REF CELL(CAMBRIDGE,MASS.) V. 118 607 2004REFN ISSN 0092-8674PMID 15339665DOI 10.1016/J.CELL.2004.08.009 Variant Set Distributions Mapped Variants
General Structure Information 3gf9 ITSN2 crystal structure of human intersectin 2 rhogef domain 2.5Å AUTH Y.SHEN,Y.TONG,W.TEMPEL,Y.LI,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN INTERSECTIN 2 RHOGEFTITL 2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2dhz RAPGEFL1 solution structure of the ra domain in the human link guanine nucleotide exchange factor ii (link-gefii) -1.0Å AUTH C.ZHAO,T.KIGAWA,M.YONEYAMA,S.KOSHIBA,T.HARADA,AUTH 2 S.WATANABE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RA DOMAIN IN THE HUMANTITL 2 LINK GUANINE NUCLEOTIDE EXCHANGE FACTOR IITITL 3 (LINK-GEFII)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4lhy RAB3IP crystal structure of gdp-bound rab8:rabin8 3.1Å AUTH Z.GUO,X.HOU,R.S.GOODY,A.ITZENTITL INTERMEDIATES IN THE GUANINE NUCLEOTIDE EXCHANGE REACTION OFTITL 2 RAB8 PROTEIN CATALYZED BY GUANINE NUCLEOTIDE EXCHANGETITL 3 FACTORS RABIN8 AND GRAB.REF J.BIOL.CHEM. V. 288 32466 2013REFN ISSN 0021-9258PMID 24072714DOI 10.1074/JBC.M113.498329 Variant Set Distributions Mapped Variants
General Structure Information 4jxh CYTH2 complexe of arno sec7 domain with the protein-protein interaction inhibitor n-(4-hydroxy-2,6-dimethylphenyl)benzenesulfonamide at ph 8.5 1.47Å AUTH J.ROUHANA,F.HOH,S.ESTARAN,C.HENRIQUET,Y.BOUBLIK,A.KERKOUR,AUTH 2 R.TROUILLARD,J.MARTINEZ,M.PUGNIERE,A.PADILLA,A.CHAVANIEUTITL FRAGMENT-BASED IDENTIFICATION OF A LOCUS IN THE SEC7 DOMAINTITL 2 OF ARNO FOR THE DESIGN OF PROTEIN-PROTEIN INTERACTIONTITL 3 INHIBITORSREF J.MED.CHEM. V. 56 8497 2013REFN ISSN 0022-2623PMID 24112024DOI 10.1021/JM4009357 Variant Set […]
General Structure Information 3fzm BAG1 crystal structures of hsc70/bag1 in complex with small molecule inhibitors 2.3Å AUTH D.S.WILLIAMSON,J.BORGOGNONI,A.CLAY,Z.DANIELS,AUTH 2 P.DOKURNO,M.J.DRYSDALE,N.FOLOPPE,G.L.FRANCIS,AUTH 3 C.J.GRAHAM,R.HOWES,A.T.MACIAS,J.B.MURRAY,R.PARSONS,AUTH 4 T.SHAW,A.E.SURGENOR,L.TERRY,Y.WANG,M.WOOD,AUTH 5 A.J.MASSEYTITL NOVEL ADENOSINE-DERIVED INHIBITORS OF 70 KDA HEATTITL 2 SHOCK PROTEIN, DISCOVERED THROUGH STRUCTURE-BASEDTITL 3 DESIGNREF J.MED.CHEM. V. 52 1510 2009REFN ISSN 0022-2623PMID 19256508DOI 10.1021/JM801627A Variant Set Distributions Ripley’s K […]
General Structure Information 3b13 DOCK2 crystal structure of the dhr-2 domain of dock2 in complex with rac1 (t17n mutant) 3.01Å AUTH K.HANAWA-SUETSUGU,M.KUKIMOTO-NIINO,C.MISHIMA-TSUMAGARI,AUTH 2 R.AKASAKA,N.OHSAWA,S.SEKINE,T.ITO,N.TOCHIO,S.KOSHIBA,AUTH 3 T.KIGAWA,T.TERADA,M.SHIROUZU,A.NISHIKIMI,T.URUNO,T.KATAKAI,AUTH 4 T.KINASHI,D.KOHDA,Y.FUKUI,S.YOKOYAMATITL STRUCTURAL BASIS FOR MUTUAL RELIEF OF THE RAC GUANINETITL 2 NUCLEOTIDE EXCHANGE FACTOR DOCK2 AND ITS PARTNER ELMO1 FROMTITL 3 THEIR AUTOINHIBITED FORMS.REF PROC.NATL.ACAD.SCI.USA V. 109 3305 […]
General Structure Information 3eo2 NET1 crystal structure of the rhogef domain of human neuroepithelial cell- transforming gene 1 protein 2.6Å AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,F.MACKENZIE,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RHOGEF DOMAIN OF HUMANTITL 2 NEUROEPITHELIAL CELL-TRANSFORMING GENE 1 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants