Assessment of Structural Intolerance and Durability
General Structure Information 2yux MYBPC1 solution structure of 3rd fibronectin type three domain of slow type myosin-binding protein c -1.0Å AUTH T.N.NIRAULA,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF 3RD FIBRONECTIN TYPE THREETITL 2 DOMAIN OF SLOW TYPE MYOSIN-BINDING PROTEIN CREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1e17 FOXO4 solution structure of the dna binding domain of the human forkhead transcription factor afx (foxo4) -1.0Å AUTH J.WEIGELT,I.CLIMENT,K.DAHLMAN-WRIGHT,M.WIKSTROMTITL 1H, 13C AND 15N RESONANCE ASSIGNMENTS OF THE DNATITL 2 BINDING DOMAIN OF THE HUMAN FORKHEAD TRANSCRIPTIONTITL 3 FACTOR AFXREF J.BIOMOL.NMR V. 17 181 2000REFN ISSN 0925-2738PMID 10921784DOI 10.1023/A:1008358816478 Variant Set Distributions […]
General Structure Information 3phw RPS27A otu domain of crimean congo hemorrhagic fever virus in complex with ubiquitin 2.0Å AUTH M.AKUTSU,Y.YE,S.VIRDEE,J.W.CHIN,D.KOMANDERTITL MOLECULAR BASIS FOR UBIQUITIN AND ISG15 CROSS-REACTIVITY INTITL 2 VIRAL OVARIAN TUMOR DOMAINS.REF PROC.NATL.ACAD.SCI.USA V. 108 2228 2011REFN ISSN 0027-8424PMID 21266548DOI 10.1073/PNAS.1015287108 Variant Set Distributions Mapped Variants
General Structure Information 2ctl HDLBP solution structure of the 13th kh type i domain from human vigilin -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 13TH KH TYPE I DOMAINTITL 2 FROM HUMAN VIGILINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dax RWDD2B solution structure of the rwd domain of human protein c21orf6 -1.0Å AUTH M.YONEYAMA,T.KIGAWA,K.SAITO,N.TOCHIO,S.KOSHIBA,AUTH 2 M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RWD DOMAIN OF HUMANTITL 2 PROTEIN C21ORF6REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3v6m CASP6 inhibition of caspase-6 activity by single mutation outside the active site 2.69Å AUTH Q.CAO,X.J.WANG,C.W.LIU,D.F.LIU,L.F.LI,Y.Q.GAO,X.D.SUTITL INHIBITORY MECHANISM OF CASPASE-6 PHOSPHORYLATION REVEALEDTITL 2 BY CRYSTAL STRUCTURES, MOLECULAR DYNAMICS SIMULATIONS, ANDTITL 3 BIOCHEMICAL ASSAYSREF J.BIOL.CHEM. V. 287 15371 2012REFN ISSN 0021-9258PMID 22433863DOI 10.1074/JBC.M112.351213 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2yuv MYBPC1 solution structure of 2nd immunoglobulin domain of slow type myosin-binding protein c -1.0Å AUTH T.N.NIRAULA,N.TOCHIO,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF 2ND IMMUNOGLOBULIN DOMAIN OFTITL 2 SLOW TYPE MYOSIN-BINDING PROTEIN CREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3sqv UBE2L3 crystal structure of e. coli o157:h7 e3 ubiquitin ligase, nlel, with a human e2, ubch7 3.3Å AUTH D.Y.LIN,J.DIAO,J.CHENTITL CRYSTAL STRUCTURES OF TWO BACTERIAL HECT-LIKE E3 LIGASES INTITL 2 COMPLEX WITH A HUMAN E2 REVEAL ATOMIC DETAILS OFTITL 3 PATHOGEN-HOST INTERACTIONS.REF PROC.NATL.ACAD.SCI.USA V. 109 1925 2012REFN ISSN 0027-8424PMID 22308380DOI 10.1073/PNAS.1115025109 Variant […]
General Structure Information 2m2f ADAM17 the membran-proximal domain of adam17 -1.0Å AUTH S.DUSTERHOFT,S.JUNG,C.W.HUNG,A.THOLEY,F.D.SONNICHSEN,AUTH 2 J.GROTZINGER,I.LORENZENTITL MEMBRANE-PROXIMAL DOMAIN OF A DISINTEGRIN ANDTITL 2 METALLOPROTEASE-17 REPRESENTS THE PUTATIVE MOLECULAR SWITCHTITL 3 OF ITS SHEDDING ACTIVITY OPERATED BY PROTEIN-DISULFIDETITL 4 ISOMERASE.REF J.AM.CHEM.SOC. V. 135 5776 2013REFN ISSN 0002-7863PMID 23521534DOI 10.1021/JA400340U Variant Set Distributions Mapped Variants
General Structure Information 2cte HDLBP solution structure of the 1st kh type i domain from human vigilin -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 1ST KH TYPE I DOMAINTITL 2 FROM HUMAN VIGILINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants