Assessment of Structural Intolerance and Durability
General Structure Information 3k0w MALT1 crystal structure of the tandem ig-like c2-type 2 domains of the human mucosa-associated lymphoid tissue lymphoma translocation protein 1 2.8Å AUTH J.R.WALKER,L.QIU,C.BUTLER-COLE,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL STRUCTURE OF THE TANDEM IG-LIKE C2-TYPE 2 DOMAINSTITL 2 OF THE HUMAN MUCOSA-ASSOCIATED LYMPHOID TISSUETITL 3 LYMPHOMA TRANSLOCATION PROTEIN 1.REF TO BE PUBLISHEDREFN Variant […]
General Structure Information 3g5c ADAM22 structural and biochemical studies on the ectodomain of human adam22 2.36Å AUTH H.LIU,A.SHIM,X.CHEN,X.HETITL STRUCTURAL AND BIOCHEMICAL STUDIES ON THE ECTODOMAIN OFTITL 2 HUMAN ADAM22REF J.BIOL.CHEM. 2009REFN ESSN 1083-351X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3bn3 ICAM5 crystal structure of icam-5 in complex with al i domain 2.1Å AUTH H.ZHANG,J.M.CASASNOVAS,M.JIN,J.H.LIU,C.G.GAHMBERG,AUTH 2 T.A.SPRINGER,J.-H.WANGTITL AN UNUSUAL ALLOSTERIC MOBILITY OF THE C-TERMINAL HELIX OF ATITL 2 HIGH-AFFINITY ALPHA L INTEGRIN I DOMAIN VARIANT BOUND TOTITL 3 ICAM-5REF MOL.CELL V. 31 432 2008REFN ISSN 1097-2765PMID 18691975DOI 10.1016/J.MOLCEL.2008.06.022 Variant Set Distributions Mapped […]
General Structure Information 2ecb ZHX1 the solution structure of the third homeobox domain of human zinc fingers and homeoboxes protein -1.0Å AUTH S.OHNISHI,N.TOCHIO,A.SASAGAWA,K.SAITO,S.KOSHIBA,AUTH 2 M.INOUE,T.KIGAWA,S.YOKOYAMATITL THE SOLUTION STRUCTURE OF THE THIRD HOMEOBOXTITL 2 DOMAIN OF HUMAN ZINC FINGERS AND HOMEOBOXES PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1jkg NXT1 structural basis for the recognition of a nucleoporin fg- repeat by the ntf2-like domain of tap-p15 mrna nuclear export factor 1.9Å AUTH S.FRIBOURG,I.C.BRAUN,E.IZAURRALDE,E.CONTITITL STRUCTURAL BASIS FOR THE RECOGNITION OF ATITL 2 NUCLEOPORIN FG REPEAT BY THE NTF2-LIKE DOMAIN OFTITL 3 THE TAP/P15 MRNA NUCLEAR EXPORT FACTOR.REF MOL.CELL V. 8 645 […]
General Structure Information 2osg TJP2 solution structure and binding property of the domain- swapped dimer of zo2pdz2 -1.0Å AUTH J.W.WU,Y.S.YANG,J.H.ZHANG,P.JI,W.J.DU,P.JIANG,AUTH 2 D.H.XIE,H.D.HUANG,M.WU,G.Z.ZHANG,J.H.WU,Y.Y.SHITITL DOMAIN-SWAPPED DIMERIZATION OF THE SECOND PDZTITL 2 DOMAIN OF ZO2 MAY PROVIDE A STRUCTURAL BASIS FORTITL 3 THE POLYMERIZATION OF CLAUDINSREF J.BIOL.CHEM. V. 282 35988 2007REFN ISSN 0021-9258PMID 17897942DOI 10.1074/JBC.M703826200 Variant Set Distributions […]
General Structure Information 3rsn ASH2L crystal structure of the n-terminal region of human ash2l 2.1Å AUTH Y.CHEN,B.WAN,K.C.WANG,F.CAO,Y.YANG,A.PROTACIO,Y.DOU,AUTH 2 H.Y.CHANG,M.LEITITL CRYSTAL STRUCTURE OF THE N-TERMINAL REGION OF HUMAN ASH2LTITL 2 SHOWS A WINGED-HELIX MOTIF INVOLVED IN DNA BINDING.REF EMBO REP. V. 12 797 2011REFN ISSN 1469-221XPMID 21660059DOI 10.1038/EMBOR.2011.101 Variant Set Distributions Mapped Variants
General Structure Information 4g34 EIF2AK3 crystal structure of gsk6924 bound to perk (r587-r1092, delete a660- t867) at 2.70 a resolution 2.7Å AUTH J.M.AXTEN,J.R.MEDINA,Y.FENG,A.SHU,S.P.ROMERIL,S.W.GRANT,AUTH 2 W.H.LI,D.A.HEERDING,E.MINTHORN,T.MENCKEN,C.ATKINS,Q.LIU,AUTH 3 S.RABINDRAN,R.KUMAR,X.HONG,A.GOETZ,T.STANLEY,J.D.TAYLOR,AUTH 4 S.D.SIGETHY,G.H.TOMBERLIN,A.M.HASSELL,K.M.KAHLER,AUTH 5 L.M.SHEWCHUK,R.T.GAMPETITL DISCOVERY OFTITL 2 7-METHYL-5-(1-{[3-(TRIFLUOROMETHYL)PHENYL]ACETYL}-2,3-TITL 3 DIHYDRO-1H-INDOL-5-YL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINETITL 4 (GSK2606414), A POTENT AND SELECTIVE FIRST-IN-CLASSTITL 5 INHIBITOR OF PROTEIN KINASE R (PKR)-LIKE ENDOPLASMICTITL 6 RETICULUM KINASE […]
General Structure Information 2kdg MYOT solution structure of the 1st ig domain of myotilin -1.0Å AUTH O.HEIKKINEN,P.PERMI,H.KOSKELA,O.CARPEN,J.YLANNE,AUTH 2 I.KILPELAINENTITL SOLUTION STRUCTURE OF THE FIRST IMMUNOGLOBULINTITL 2 DOMAIN OF HUMAN MYOTILINREF J.BIOMOL.NMR V. 44 107 2009REFN ISSN 0925-2738PMID 19418025DOI 10.1007/S10858-009-9320-4 Variant Set Distributions Mapped Variants
General Structure Information 1iur SACS dnaj domain of human kiaa0730 protein -1.0Å AUTH N.KOBAYASHI,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF DNAJ DOMAIN OF HUMANTITL 2 KIAA0730 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants