Assessment of Structural Intolerance and Durability
General Structure Information 2fmm C11orf30 crystal structure of emsy-hp1 complex 1.8Å AUTH Y.HUANG,M.P.MYERS,R.M.XUTITL CRYSTAL STRUCTURE OF THE HP1-EMSY COMPLEX REVEALS AN UNUSUALTITL 2 MODE OF HP1 BINDING.REF STRUCTURE V. 14 703 2006REFN ISSN 0969-2126PMID 16615912DOI 10.1016/J.STR.2006.01.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1wfm SYT13 the first c2 domain of human synaptotagmin xiii -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL THE FIRST C2 DOMAIN OF HUMAN SYNAPTOTAGMIN XIIIREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dlu INADL solution structure of the second pdz domain of human inad- like protein -1.0Å AUTH K.INOUE,C.KUROSAKI,K.IZUMI,M.YOSHIDA,F.HAYASHI,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND PDZ DOMAIN OFTITL 2 HUMAN INAD-LIKE PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4h8s APPL2 crystal structure of human appl2barph domain 3.5Å AUTH G.J.KING,J.STOCKLI,S.H.HU,B.WINNEN,W.G.DUPREZ,C.C.MEOLI,AUTH 2 J.R.JUNUTULA,R.J.JARROTT,D.E.JAMES,A.E.WHITTEN,J.L.MARTINTITL MEMBRANE CURVATURE PROTEIN EXHIBITS INTERDOMAIN FLEXIBILITYTITL 2 AND BINDS A SMALL GTPASE.REF J.BIOL.CHEM. V. 287 40996 2012REFN ISSN 0021-9258PMID 23055524DOI 10.1074/JBC.M112.349803 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2d93 RAPGEF6 solution structure of the cnmp_binding domain of human rap guanine nucleotide exchange factor 6 -1.0Å AUTH K.INOUE,Y.MUTO,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CNMP_BINDING DOMAIN OFTITL 2 HUMAN RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2co8 MICAL1 solution structures of the lim domain of human nedd9 interacting protein with calponin homology and lim domains -1.0Å AUTH M.SATO,T.TOMIZAWA,K.SAITO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE LIM DOMAIN OF HUMANTITL 2 NEDD9 INTERACTING PROTEIN WITH CALPONIN HOMOLOGYTITL 3 AND LIM DOMAINSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dnl CPEB3 solution structure of rna binding domain in cytoplasmic polyadenylation element binding protein 3 -1.0Å AUTH K.TSUDA,T.NAGATA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF RNA BINDING DOMAIN INTITL 2 CYTOPLASMIC POLYADENYLATION ELEMENT BINDINGTITL 3 PROTEIN 3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3o7x PIWIL2 crystal structure of human hili paz domain 2.92Å AUTH Y.TIAN,D.K.SIMANSHU,J.B.MA,D.J.PATELTITL INAUGURAL ARTICLE: STRUCTURAL BASIS FOR PIRNATITL 2 2-O-METHYLATED 3-END RECOGNITION BY PIWI PAZTITL 3 (PIWI/ARGONAUTE/ZWILLE) DOMAINS.REF PROC.NATL.ACAD.SCI.USA V. 108 903 2011REFN ISSN 0027-8424PMID 21193640DOI 10.1073/PNAS.1017762108 Variant Set Distributions Mapped Variants
General Structure Information 3t6g SH2D3C structure of the complex between nsp3 (shep1) and p130cas 2.5Å AUTH P.D.MACE,Y.WALLEZ,M.K.DOBACZEWSKA,J.J.LEE,H.ROBINSON,AUTH 2 E.B.PASQUALE,S.J.RIEDLTITL NSP-CAS PROTEIN STRUCTURES REVEAL A PROMISCUOUS INTERACTIONTITL 2 MODULE IN CELL SIGNALING.REF NAT.STRUCT.MOL.BIOL. V. 18 1381 2011REFN ISSN 1545-9993PMID 22081014DOI 10.1038/NSMB.2152 Variant Set Distributions Mapped Variants
General Structure Information 4nf9 CASC5 structure of the knl1/nsl1 complex 2.8Å AUTH A.PETROVIC,S.MOSALAGANTI,J.KELLER,M.MATTIUZZO,K.OVERLACK,AUTH 2 V.KRENN,A.DE ANTONI,S.WOHLGEMUTH,V.CECATIELLO,S.PASQUALATO,AUTH 3 S.RAUNSER,A.MUSACCHIOTITL MODULAR ASSEMBLY OF RWD DOMAINS ON THE MIS12 COMPLEXTITL 2 UNDERLIES OUTER KINETOCHORE ORGANIZATION.REF MOL.CELL V. 53 591 2014REFN ISSN 1097-2765PMID 24530301DOI 10.1016/J.MOLCEL.2014.01.019 Variant Set Distributions Mapped Variants