Assessment of Structural Intolerance and Durability
General Structure Information 3kt9 APTX aprataxin fha domain 1.65Å AUTH O.J.BECHEREL,B.JAKOB,A.L.CHERRY,N.GUEVEN,M.FUSSER,AUTH 2 A.W.KIJAS,C.PENG,S.KATYAL,P.J.MCKINNON,J.CHEN,AUTH 3 B.EPE,S.J.SMERDON,G.TAUCHER-SCHOLZ,M.F.LAVINTITL CK2 PHOSPHORYLATION-DEPENDENT INTERACTION BETWEENTITL 2 APRATAXIN AND MDC1 IN THE DNA DAMAGE RESPONSE.REF NUCLEIC ACIDS RES. V. 38 1489 2010REFN ISSN 0305-1048PMID 20008512DOI 10.1093/NAR/GKP1149 Variant Set Distributions Mapped Variants
General Structure Information 2dm8 INADL solution structure of the eighth pdz domain of human inad- like protein -1.0Å AUTH K.INOUE,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE EIGHTH PDZ DOMAIN OFTITL 2 HUMAN INAD-LIKE PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1mi1 NBEA crystal structure of the ph-beach domain of human neurobeachin 2.9Å AUTH G.JOGL,Y.SHEN,D.GEBAUER,J.LI,K.WIEGMANN,H.KASHKAR,AUTH 2 M.KRONKE,L.TONGTITL CRYSTAL STRUCTURE OF THE BEACH DOMAIN REVEALS ANTITL 2 UNUSUAL FOLD AND EXTENSIVE ASSOCIATION WITH ATITL 3 NOVEL PH DOMAIN.REF EMBO J. V. 21 4785 2002REFN ISSN 0261-4189PMID 12234919DOI 10.1093/EMBOJ/CDF502 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2yrl KIAA0319L solution structure of the pkd domain from kiaa 1837 protein -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PKD DOMAIN FROM KIAATITL 2 1837 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3pkj SIRT6 human sirt6 crystal structure in complex with 2-n-acetyl adp ribose 2.12Å AUTH P.W.PAN,A.DONG,J.MIN,C.ARROWSMITH,A.EDWARDSTITL HUMAN SIRT6 CRYSTAL STRUCTURE IN COMPLEX WITH 2-N-ACETYLTITL 2 ADP RIBOSEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1iq3 REPS2 solution structure of the eps15 homology domain of a human pob1 -1.0Å AUTH S.KOSHIBA,T.KIGAWA,J.IWAHARA,A.KIKUCHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE EPS15 HOMOLOGY DOMAIN OFTITL 2 A HUMAN POB1 (PARTNER OF RALBP1).REF FEBS LETT. V. 442 138 1999REFN ISSN 0014-5793PMID 9928989DOI 10.1016/S0014-5793(98)01644-5 Variant Set Distributions Mapped Variants
General Structure Information 2dmz INADL solution structure of the third pdz domain of human inad- like protein -1.0Å AUTH K.INOUE,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD PDZ DOMAIN OFTITL 2 HUMAN INAD-LIKE PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3gcw PCSK9 pcsk9:egfa(h306y) 2.7Å AUTH M.C.MCNUTT,H.J.KWON,C.CHEN,J.R.CHEN,J.D.HORTON,T.A.LAGACETITL ANTAGONISM OF SECRETED PCSK9 INCREASES LOW DENSITYTITL 2 LIPOPROTEIN RECEPTOR EXPRESSION IN HEPG2 CELLS.REF J.BIOL.CHEM. V. 284 10561 2009REFN ISSN 0021-9258PMID 19224862DOI 10.1074/JBC.M808802200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ysm KMT2C solution structure of the first and second phd domain from myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST AND SECOND PHDTITL 2 DOMAIN FROM MYELOID/LYMPHOID OR MIXED-LINEAGETITL 3 LEUKEMIA PROTEIN 3 HOMOLOGREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3icu RNF128 protease-associated domain of the e3 ligase grail 2.1Å AUTH J.R.WALKER,L.YERMEKBAYEVA,A.SEITOVA,J.WEIGELT,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL PA DOMAIN OF THE E3 LIGASE GRAILREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants