Assessment of Structural Intolerance and Durability
General Structure Information 3rbn MLH1 crystal structure of mutl protein homolog 1 isoform 1 [homo sapiens] 2.16Å AUTH L.DOMBROVSKY,A.DONG,A.WERNIMONT,P.LOPPNAU,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,H.WUTITL CRYSTAL STRUCTURE OF MUTL PROTEIN HOMOLOG 1 ISOFORM 1 [HOMOTITL 2 SAPIENS]REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3q8k FEN1 crystal structure of human flap endonuclease fen1 (wt) in complex with product 5-flap dna, sm3+, and k+ 2.2Å AUTH S.E.TSUTAKAWA,S.CLASSEN,B.R.CHAPADOS,A.S.ARVAI,L.D.FINGER,AUTH 2 G.GUENTHER,C.G.TOMLINSON,P.THOMPSON,A.H.SARKER,B.SHEN,AUTH 3 P.K.COOPER,J.A.GRASBY,J.A.TAINERTITL HUMAN FLAP ENDONUCLEASE STRUCTURES, DNA DOUBLE-BASETITL 2 FLIPPING, AND A UNIFIED UNDERSTANDING OF THE FEN1TITL 3 SUPERFAMILY.REF CELL(CAMBRIDGE,MASS.) V. 145 198 2011REFN ISSN 0092-8674PMID 21496641DOI 10.1016/J.CELL.2011.03.004 […]
General Structure Information 2rnr GTF2H1 solution structure of the complex between tfiie alpha c- terminal acidic domain and tfiih p62 ph domain -1.0Å AUTH M.OKUDA,A.TANAKA,M.SATOH,S.MIZUTA,M.TAKAZAWA,AUTH 2 Y.OHKUMA,Y.NISHIMURATITL STRUCTURAL INSIGHT INTO THE TFIIE-TFIIHTITL 2 INTERACTION: TFIIE AND P53 SHARE THE BINDINGTITL 3 REGION ON TFIIHREF EMBO J. V. 27 1161 2008REFN ISSN 0261-4189PMID 18354501DOI 10.1038/EMBOJ.2008.47 Variant […]
General Structure Information 2k6g RFC1 solution structure of the dna binding brct domain from the large subunit of human replication factor c -1.0Å AUTH M.KOBAYASHI,E.AB,A.M.J.J.BONVIN,G.SIEGALTITL SOLUTION STRUCTURE OF THE DNA BOUND BRCT DOMAINTITL 2 FROM HUMAN REPLICATION FACTOR C P140REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dao ETV6 solution structure of ets domain transcriptional factor etv6 protein -1.0Å AUTH T.N.NIRAULA,A.SASAGAWA,T.TOMIZAWA,S.KOSHIBA,AUTH 2 M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF ETS DOMAIN TRANSCRIPTIONALTITL 2 FACTOR ETV6 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1n83 RORA crystal structure of the complex between the orphan nuclear hormone receptor ror(alpha)-lbd and cholesterol 1.63Å AUTH J.A.KALLEN,J.M.SCHLAEPPI,F.BITSCH,S.GEISSE,AUTH 2 M.GEISER,I.DELHON,B.FOURNIERTITL X-RAY STRUCTURE OF HROR(ALPHA) LBD AT 1.63A:TITL 2 STRUCTURAL AND FUNCTIONAL DATA THAT CHOLESTEROL ORTITL 3 A CHOLESTEROL DERIVATIVE IS THE NATURAL LIGAND OFTITL 4 ROR(ALPHA)REF STRUCTURE V. 10 1697 2002REFN […]
General Structure Information 2lrr IGHMBP2 solution structure of the r3h domain from human smubp-2 in complex with 2-deoxyguanosine-5-monophosphate -1.0Å AUTH K.JAUDZEMS,X.JIA,H.YAGI,D.ZHULENKOVS,B.GRAHAM,G.OTTING,AUTH 2 E.LIEPINSHTITL STRUCTURAL BASIS FOR 5-END-SPECIFIC RECOGNITION OFTITL 2 SINGLE-STRANDED DNA BY THE R3H DOMAIN FROM HUMAN SMUBP-2REF J.MOL.BIOL. V. 12 760 2012REFN ISSN 0022-2836PMID 22999958DOI 10.1016/J.JMB.2012.09.010 Variant Set Distributions Mapped Variants
General Structure Information 2wwy RECQL structure of human recq-like helicase in complex with a dna substrate 2.9Å AUTH A.C.W.PIKE,Y.ZHANG,C.SCHNECKE,A.CHAIKUAD,T.KROJER,AUTH 2 C.D.O.COOPER,F.VON DELFT,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.EDWARDS,C.BOUNTRA,O.GILEADITITL RECQ1 HELICASE-DRIVEN DNA UNWINDING, ANNEALING, AND BRANCHTITL 2 MIGRATION: INSIGHTS FROM DNA COMPLEX STRUCTURESREF PROC.NATL.ACAD.SCI.USA V. 112 4286 2015REFN ISSN 0027-8424PMID 25831490DOI 10.1073/PNAS.1417594112 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2obh CETN2 centrin-xpc peptide 1.8Å AUTH J.B.CHARBONNIER,E.RENAUD,S.MIRON,M.H.LE DU,Y.BLOUQUIT,AUTH 2 P.DUCHAMBON,P.CHRISTOVA,A.SHOSHEVA,T.ROSE,J.F.ANGULO,AUTH 3 C.T.CRAESCUTITL STRUCTURAL, THERMODYNAMIC, AND CELLULAR CHARACTERIZATION OFTITL 2 HUMAN CENTRIN 2 INTERACTION WITH XERODERMA PIGMENTOSUM GROUPTITL 3 C PROTEIN.REF J.MOL.BIOL. V. 373 1032 2007REFN ISSN 0022-2836PMID 17897675DOI 10.1016/J.JMB.2007.08.046 Variant Set Distributions Mapped Variants
General Structure Information 2o8b MSH2 human mutsalpha (msh2/msh6) bound to adp and a g t mispair 2.75Å AUTH J.J.WARREN,T.J.POHLHAUS,A.CHANGELA,R.R.IYER,P.L.MODRICH,AUTH 2 L.S.BEESETITL STRUCTURE OF THE HUMAN MUTSALPHA DNA LESION RECOGNITIONTITL 2 COMPLEX.REF MOL.CELL V. 26 579 2007REFN ISSN 1097-2765PMID 17531815DOI 10.1016/J.MOLCEL.2007.04.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants