Assessment of Structural Intolerance and Durability
General Structure Information 2a1i ERCC1 crystal structure of the central domain of human ercc1 1.9Å AUTH O.V.TSODIKOV,J.H.ENZLIN,O.D.SCHARER,T.ELLENBERGERTITL CRYSTAL STRUCTURE AND DNA BINDING FUNCTIONS OFTITL 2 ERCC1, A SUBUNIT OF THE DNA STRUCTURE-SPECIFICTITL 3 ENDONUCLEASE XPF-ERCC1.REF PROC.NATL.ACAD.SCI.USA V. 102 11236 2005REFN ISSN 0027-8424PMID 16076955DOI 10.1073/PNAS.0504341102 Variant Set Distributions Mapped Variants
General Structure Information 4irg ERG uninhibited dna-binding domain of the ets transcription factor erg 1.7Å AUTH M.C.REGAN,P.S.HORANYI,E.E.PRYOR,J.L.SARVER,D.S.CAFISO,AUTH 2 J.H.BUSHWELLERTITL STRUCTURAL AND DYNAMIC STUDIES OF THE TRANSCRIPTION FACTORTITL 2 ERG REVEAL DNA BINDING IS ALLOSTERICALLY AUTOINHIBITED.REF PROC.NATL.ACAD.SCI.USA V. 110 13374 2013REFN ISSN 0027-8424PMID 23898196DOI 10.1073/PNAS.1301726110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1x3c ZNF292 solution structure of the c2h2 type zinc-binding domain of human zinc finger protein 292 -1.0Å AUTH M.YONEYAMA,T.TOMIZAWA,N.TOCHIO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C2H2 TYPE ZINC-BINDINGTITL 2 DOMAIN OF HUMAN ZINC FINGER PROTEIN 292REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3dal PRDM1 methyltransferase domain of human pr domain-containing protein 1 1.65Å AUTH H.ZENG,M.F.AMAYA,T.ANTOSHENKO,A.DONG,P.LOPPNAU,AUTH 2 A.BOCHKAREV,J.MIN,A.N.PLOTNIKOV,H.WUTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAINTITL 2 OF HUMAN PR DOMAIN-CONTAINING PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ryu ARID1A solution structure of the swi1 arid -1.0Å AUTH S.KIM,Z.ZHANG,S.UPCHURCH,N.ISERN,Y.CHENTITL STRUCTURE AND DNA-BINDING SITES OF THE SWI1TITL 2 AT-RICH INTERACTION DOMAIN (ARID) SUGGESTTITL 3 DETERMINANTS FOR SEQUENCE-SPECIFIC DNA RECOGNITION.REF J.BIOL.CHEM. V. 279 16670 2004REFN ISSN 0021-9258PMID 14722072DOI 10.1074/JBC.M312115200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2k86 FOXO3 solution structure of foxo3a forkhead domain -1.0Å AUTH F.WANG,C.B.MARSHALL,K.YAMAMOTO,G.Y.LI,M.J.PLEVIN,AUTH 2 H.YOU,T.W.MAK,M.IKURATITL BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF ANTITL 2 INTRAMOLECULAR INTERACTION IN FOXO3A AND ITSTITL 3 BINDING WITH P53.REF J.MOL.BIOL. V. 384 590 2008REFN ISSN 0022-2836PMID 18824006DOI 10.1016/J.JMB.2008.09.025 Variant Set Distributions Mapped Variants