Assessment of Structural Intolerance and Durability
General Structure Information 1h5p SP100 solution structure of the human sp100b sand domain by heteronuclear nmr. -1.0Å AUTH M.J.BOTTOMLEY,M.W.COLLARD,J.I.HUGGENVIK,Z.LIU,AUTH 2 T.J.GIBSON,M.SATTLERTITL THE SAND DOMAIN STRUCTURE DEFINES A NOVEL DNATITL 2 BINDING FOLD IN TRANSCRIPTIONAL REGULATIONREF NAT.STRUCT.BIOL. V. 8 626 2001REFN ISSN 1072-8368PMID 11427895DOI 10.1038/89675 Variant Set Distributions Mapped Variants
General Structure Information 3epz DNMT1 structure of the replication foci-targeting sequence of human dna cytosine methyltransferase dnmt1 2.31Å AUTH F.SYEDA,R.L.FAGAN,M.WEAN,G.V.AVVAKUMOV,J.R.WALKER,S.XUE,AUTH 2 S.DHE-PAGANON,C.BRENNERTITL THE REPLICATION FOCUS TARGETING SEQUENCE (RFTS) DOMAIN IS ATITL 2 DNA-COMPETITIVE INHIBITOR OF DNMT1.REF J.BIOL.CHEM. V. 286 15344 2011REFN ISSN 0021-9258PMID 21389349DOI 10.1074/JBC.M110.209882 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3ri4 ETS1 ets1 cooperative binding to widely separated sites on promoter dna 3.0Å AUTH N.D.BABAYEVA,O.I.BARANOVSKAYA,T.H.TAHIROVTITL STRUCTURAL BASIS OF ETS1 COOPERATIVE BINDING TO WIDELYTITL 2 SEPARATED SITES ON PROMOTER DNA.REF PLOS ONE V. 7 33698 2012REFN ESSN 1932-6203PMID 22432043DOI 10.1371/JOURNAL.PONE.0033698 Variant Set Distributions Mapped Variants
General Structure Information 2yrq HMGB1 solution structure of the tandem hmg box domain from human high mobility group protein b1 -1.0Å AUTH T.TOMIZAWA,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE TANDEM HMG BOX DOMAINTITL 2 FROM HUMAN HIGH MOBILITY GROUP PROTEIN B1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4mzr TP53 crystal structure of a polypeptide p53 mutant bound to dna 2.9Å AUTH S.EMAMZADAH,L.TROPIA,I.VINCENTI,B.FALQUET,T.D.HALAZONETISTITL REVERSAL OF THE DNA-BINDING-INDUCED LOOP L1 CONFORMATIONALTITL 2 SWITCH IN AN ENGINEERED HUMAN P53 PROTEIN.REF J.MOL.BIOL. V. 426 936 2014REFN ISSN 0022-2836PMID 24374182DOI 10.1016/J.JMB.2013.12.020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2m16 PSIP1 p75/ledgf pwwp domain -1.0Å AUTH J.O.EIDAHL,B.L.CROWE,J.A.NORTH,C.J.MCKEE,N.SHKRIABAI,L.FENG,AUTH 2 M.PLUMB,R.L.GRAHAM,R.J.GORELICK,S.HESS,M.G.POIRIER,AUTH 3 M.P.FOSTER,M.KVARATSKHELIATITL STRUCTURAL BASIS FOR HIGH-AFFINITY BINDING OF LEDGF PWWP TOTITL 2 MONONUCLEOSOMES.REF NUCLEIC ACIDS RES. V. 41 3924 2013REFN ISSN 0305-1048PMID 23396443DOI 10.1093/NAR/GKT074 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1x3c ZNF292 solution structure of the c2h2 type zinc-binding domain of human zinc finger protein 292 -1.0Å AUTH M.YONEYAMA,T.TOMIZAWA,N.TOCHIO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C2H2 TYPE ZINC-BINDINGTITL 2 DOMAIN OF HUMAN ZINC FINGER PROTEIN 292REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4drb STRA13 the crystal structure of fancm bound mhf complex 2.63Å AUTH Y.TAO,C.JIN,X.LI,S.QI,L.CHU,L.NIU,X.YAO,M.TENGTITL THE STRUCTURE OF THE FANCM-MHF COMPLEX REVEALS PHYSICALTITL 2 FEATURES FOR FUNCTIONAL ASSEMBLYREF NAT COMMUN V. 3 782 2012REFN ESSN 2041-1723PMID 22510687DOI 10.1038/NCOMMS1779 Variant Set Distributions Mapped Variants
General Structure Information 2cru PDCD5 solution structure of programmed cell death 5 -1.0Å AUTH T.NAGASHIMA,K.IZUMI,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF PROGRAMMED CELL DEATH 5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3rn5 AIM2 structural basis of cytosolic dna recognition by innate immune receptors 2.5Å AUTH T.JIN,A.PERRY,J.JIANG,P.SMITH,J.A.CURRY,L.UNTERHOLZNER,AUTH 2 Z.JIANG,G.HORVATH,V.A.RATHINAM,R.W.JOHNSTONE,V.HORNUNG,AUTH 3 E.LATZ,A.G.BOWIE,K.A.FITZGERALD,T.S.XIAOTITL STRUCTURES OF THE HIN DOMAIN:DNA COMPLEXES REVEAL LIGANDTITL 2 BINDING AND ACTIVATION MECHANISMS OF THE AIM2 INFLAMMASOMETITL 3 AND IFI16 RECEPTOR.REF IMMUNITY V. 36 561 2012REFN ISSN 1074-7613PMID 22483801DOI 10.1016/J.IMMUNI.2012.02.014 Variant Set Distributions […]